The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antibody-Catalyzed Degradation of Cocaine
Abstract
Immunization with a phosphonate monoester transition-state analog of cocaine provided monoclonal antibodies capable of catalyzing the hydrolysis of the cocaine benzoyl ester group. An assay for the degradation of radiolabeled cocaine identified active enzymes. Benzoyl esterolysis yields ecgonine methyl ester and benzoic acid, fragments devoid of cocaine's stimulant activity. Passive immunization with such an artificial enzyme could provide a treatment for dependence by blunting reinforcement.
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Citations
Cites
Gawin, F. H., & Ellinwood, E. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181806 · Cited by 965
Desipramine Facilitation of Initial Cocaine Abstinence
Gawin, F. H. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810020019004 · Cited by 361
Cited by
Management of Cocaine Abuse and Dependence
Mendelson, J. H., & Mello, N. K. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341507 · Cited by 291
Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists
Singh, S. (2000) · Chemical Reviews · doi:10.1021/cr9700538 · Cited by 267
Metadata
- Authors
- Landry, D. W., Zhao, K., Yang, G. X.-Q., Glickman, M., & Georgiadis, T. M.
- Venue
- Science
- Published
- 1993-03-26
- Volume
- 259
- Issue
- 5103
- Pages
- 1899-1901
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984120373
- Cited by
- 252
- References
- 2
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landry, D. W., Zhao, K., Yang, G. X.-Q., Glickman, M., & Georgiadis, T. M. (1993). Antibody-Catalyzed Degradation of Cocaine. Science. https://doi.org/10.1126/science.8456315
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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