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Cited by 295Substance Abuse Treatment and OutcomesOpioid Use Disorder TreatmentYouth, Drugs, and Violence

Management of Cocaine Abuse and Dependence

Mendelson, Jack H., Mello, Nancy K.·1996·New England Journal of Medicine
DOI 10.1056/nejm199604113341507
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Abstract

During the 20th century, there have been recurrent episodes of cocaine abuse in the United States that have achieved epidemic proportions.1 Although the total number of people using the drug has decreased in the past decade, cocaine-related biomedical and psychosocial problems remain a major public health problem in the United States and many other countries. The expanding list of cocaine-related toxic effects, acute and chronic, includes reproductive dysfunction, hepatic necrosis, and pulmonary disease.2 Abuse of and dependence on cocaine may also be associated with disorders of sexual function, sleep, anxiety, and mood, as well as with delirium and psychotic disorders. . . .

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Crossref · 10.1056/nejm199604113341507

Cites

113 of 113 references verified0 citation errors · 0 not checkable

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  • Persistent postwithdrawal disorders have been described with different classes of CNS drugs (e.g. protracted insomnia for alcohol and benzodiazepine withdrawal and major depression/dysphoria for cocaine and amphetamine withdrawal), and even more so with specific drugs (e.g. quetiapine and paroxetine) within a drug class.

    “Persistent postwithdrawal disorders have been described with different classes of CNS drugs (e.g.protracted insomnia for alcohol and benzodiazepine withdrawal [10,36] and major depression/dysphoria for cocaine and amphetamine withdrawal [10,23] ), and even more so with specific drugs (e.g.quetiapine and paroxetine) within a drug class [6,15,16,33] .”

    From New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal (2015) · cites this paper as [16]

  • There is increasing evidence for postwithdrawal disorders with SSRI long-term use.

    “We now have increasing evidence for postwithdrawal disorders with SSRI long-term use [6,15,16,26,37] .”

    From New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal (2015) · cites this paper as [16]

  • Data from controlled trials, case reports, and online patient reports show that paroxetine is most likely to be associated with new withdrawal symptoms, and fluoxetine the least.

    “Data from controlled trials [15,20,29] , case reports [16] , and online patient reports [26] show that paroxetine is most likely to be associated with new withdrawal symptoms, and fluoxetine the least.”

    From New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal (2015) · cites this paper as [16]

  • According to most studies, even with gradual tapering, withdrawal symptoms still occur.

    “According to most studies [1,15,16,20,29] , even with gradual tapering, withdrawal symptoms still occur.”

    From New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal (2015) · cites this paper as [16]

  • Fava et al. conducted a study of gradual SSRI discontinuation in panic disorder and found that 9 of 20 patients (45%) experienced new withdrawal symptoms, and that 3 of the 9 (33%) patients treated with paroxetine had postwithdrawal disorders at 1 year of follow-up, including bipolar spectrum disorder (n=2) and major depressive disorder (n=1).

    “Fava et al. [16] conducted a study of gradual SSRI discontinuation in panic disorder and found that 9 of 20 patients (45%) experienced new withdrawal symptoms, and that 3 of the 9 (33%) patients treated with paroxetine had postwithdrawal disorders at 1 year of follow-up, including bipolar spectrum disorder (n = 2) and major depressive disorder (n = 1).”

    From New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal (2015) · cites this paper as [16]

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Authors
Mendelson, J. H., & Mello, N. K.
Affiliations
Harvard University (US)
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1996-04-11
Volume
334
Issue
15
Pages
965-972
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199604113341507
OpenAlex
W2338649220
Cited by
291
References
112
Citations by year
2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 20 · 2012: 14
FWCI
5.15
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r18da006116-05)
  • National Institute on Drug Abuse (DA 06116, K05DA000064, KO5-DA 00101, KO5 DA 00064, K05DA000101)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Social Sciences › Demography › Youth, Drugs, and Violence
Keywords
cocaine abuse, cocaine dependence, cocaine toxicity, reproductive disorders, liver necrosis, lung disease, sexual dysfunction, sleep disorders, anxiety, mood disorders, delirium, psychosis
MeSH terms
Antidepressive Agents, Carbamazepine, Cocaine, Humans, Narcotic Antagonists, Narcotics, Dopamine Agents, Substance-Related Disorders

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