The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Force of Single Kinesin Molecules Measured with Optical Tweezers
Abstract
Isometric forces generated by single molecules of the mechanochemical enzyme kinesin were measured with a laser-induced, single-beam optical gradient trap, also known as optical tweezers. For the microspheres used in this study, the optical tweezers was spring-like for a radius of 100 nanometers and had a maximum force region at a radius of ∼150 nanometers. With the use of biotinylated microtubules and special streptavidin-coated latex microspheres as handles, microtubule translocation by single squid kinesin molecules was reversibly stalled. The stalled microtubules escaped optical trapping forces of 1.9 ± 0.4 piconewtons. The ability to measure force parameters of single macromolecules now allows direct testing of molecular models for contractility.
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Citations
Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Self-citationBead movement by single kinesin molecules studied with optical tweezers
Block, S. M., Goldstein, L. S. B., & Schnapp, B. J. (1990) · Nature · doi:10.1038/348348a0 · Cited by 1,038
Cited by
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Translating Biomolecular Recognition into Nanomechanics
Fritz, J., Baller, M. K., Lang, H. P., Rothuizen, H., Vettiger, P., Meyer, E., -J. Güntherodt, H., Gerber, C., & Gimzewski, J. K. (2000) · Science · doi:10.1126/science.288.5464.316 · Cited by 1,646
Force and velocity measured for single kinesin molecules
Svoboda, K., & Block, S. M. (1994) · Cell · doi:10.1016/0092-8674(94)90060-4 · Cited by 909
Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J. D., Sheetz, M. P., & Meyer, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81560-3 · Cited by 675
Self-citationMicrotubules and microtubule-associated proteins
Mandelkow, E., & Mandelkow, E.-M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80047-6 · Cited by 458
Metadata
- Authors
- Kuo, S. C., & Sheetz, M. P.
- Venue
- Science
- Published
- 1993-04-09
- Volume
- 260
- Issue
- 5105
- Pages
- 232-234
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036745732
- Cited by
- 424
- References
- 2
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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