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Cited by 2,710

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Clues to the Pathogenesis of Familial Colorectal Cancer

Aaltonen, Lauri A., Peltomäki, Päivi, Leach, Fredrick S., Sistonen, Pertti, Pylkkänen, Lea, Mecklin, Jukka-Pekka, Järvinen, Heikki, Powell, Steven M., Jen, Jin, Hamilton, Stanley R., Petersen, Gloria M., Kinzler, Kenneth W., Vogelstein, Bert, de la Chapelle, Albert·1993·Science
DOI 10.1126/science.8484121
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Abstract

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of sporadic colon cancers. Neither the familial nor sporadic cancers showed loss of heterozygosity for chromosome 2 markers, and the incidence of mutations in KRAS,P53, and APC was similar in the two groups of tumors. Most of the familial cancers, however, had widespread alterations in short repeated DNA sequences, suggesting that numerous replication errors had occurred during tumor development. Thirteen percent of sporadic cancers had identical abnormalities and these cancers shared biologic properties with the familial cases. These data suggest a mechanism for familial tumorigenesis different from that mediated by classic tumor suppressor genes.

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Crossref · 10.1126/science.8484121

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Metadata

Authors
Aaltonen, L. A., Peltomäki, P., Leach, F. S., Sistonen, P., Pylkkänen, L., Mecklin, J.-P., Järvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B., & de la Chapelle, A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-05-07
Volume
260
Issue
5109
Pages
812-816
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8484121
OpenAlex
W2044643325
Cited by
2,710
References
1
FWCI
132.32
Type
journal article
Language
en
Open access
closed

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