Telomeres, telomerase and colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is the third most common cancer worldwide and, despite improved treatments, is still an important cause of cancer-related deaths. CRC encompasses a complex of diseases arising from a multi-step process of genetic and epigenetic events. Besides heterogeneity in the molecular and biological features of CRC, chromosomal instability is a hallmark of cancer and cancer cells may also circumvent replicative senescence and acquire the ability to sustain unlimited proliferation. Telomere/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential, and its dysfunction plays a key role in the oncogenetic process. The erosion of telomeres, mainly because of cell proliferation, may be accelerated by specific alterations in the genes involved in CRC, such as APC and MSH2. Although there is general agreement that the shortening of telomeres plays a role in the early steps of CRC carcinogenesis by promoting chromosomal instability, the prognostic role of telomere length in CRC is still under debate. The activation of telomerase reverse transcriptase (TERT), the catalytic component of the telomerase complex, allows cancer cells to grow indefinitely by maintaining the length of the telomeres, thus favouring tumour formation/progression. Several studies indicate that TERT increases with disease progression, and most studies suggest that telomerase is a useful prognostic factor. Plasma TERT mRNA may also be a promising marker for the minimally invasive monitoring of disease progression and response to therapy.
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Researchers have identified telomerase activity as an independent prognostic factor for disease-free survival, recurrence, and overall survival in CRC patients, with high levels of TERT and/or telomerase activity typically associated with poorer prognosis.
“Researchers have identified TA as an independent prognostic factor for DFS, recurrence, and OS in CRC patients, with high levels of TERT and/or TA typically associated with poorer prognosis [204].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [204]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Correspondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · see citing works
Clues to the Pathogenesis of Familial Colorectal Cancer
Aaltonen, L. A., Peltomäki, P., Leach, F. S., Sistonen, P., Pylkkänen, L., Mecklin, J., Järvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., et al. (1993) · Science · doi:10.1126/science.8484121 · Cited by 2,709 · see citing works
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456 · see citing works
Drug delivery with carbon nanotubes for in vivo cancer treatment
Liu, Z., Chen, K., Davis, C. R., Sherlock, S. P., Cao, Q., Chen, X. S., & Dai, H. (2008) · PubMed · doi:10.48550/arxiv.0808.2070 · Cited by 2,287 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
Ribic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022289 · Cited by 2,160 · see citing works
Molecular Basis of Colorectal Cancer
Markowitz, S. D., & Bertagnolli, M. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804588 · Cited by 2,052 · see citing works
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995 · see citing works
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
Sargent, D. J., Marsoni, S., Monges, G., Thibodeau, S. N., Labianca, R., Hamilton, S. R., French, A. J., Kabat, B., Foster, N. R., Torri, V., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.1825 · Cited by 1,623 · see citing works
Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study
QUASAR Collaborative Group (2007) · The Lancet · doi:10.1016/s0140-6736(07)61866-2 · Cited by 1,435 · see citing works
Benson, A. B., Schrag, D., Somerfield, M. R., Cohen, A. M., Figueredo, A. T., Flynn, P. J., Krzyzanowska, M. K., Maroun, J. A., McAllister, P. K., Cutsem, E. V., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.063 · Cited by 1,430 · see citing works
Cunningham, D., Atkin, W. S., Lenz, H., Lynch, H. T., Minsky, B. D., Nordlinger, B., & Starling, N. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60353-4 · Cited by 1,407 · see citing works
RAF/RAS oncogenes and mismatch-repair status
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature · doi:10.1038/418934a · Cited by 1,224 · see citing works
Gill, S., Loprinzi, C. L., Sargent, D. J., Thomé, S. D., Alberts, S. R., Haller, D. G., Benedetti, J., Francini, G., Shepherd, L. E., Seitz, J. F., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.059 · Cited by 1,019 · see citing works
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 992 · see citing works
The Chromosomal Instability Pathway in Colon Cancer
Pino, M. S., & Chung, D. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.065 · Cited by 941 · see citing works
Ogino, S., Nosho, K., Kirkner, G. J., Kawasaki, T., Meyerhardt, J. A., Loda, M. F., Giovannucci, E. L., & Fuchs, C. S. (2008) · Gut · doi:10.1136/gut.2008.155473 · Cited by 772 · see citing works
de Kok, J. B., Roelofs, R., Giesendorf, B. A. J., Pennings, J. L. A., Waas, E. T., Feuth, T. B., Swinkels, D. W., & Span, P. N. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700208 · Cited by 580 · see citing works
Ulaner, G. A., Hu, J., Vu, T. H., Giudice, L. C., & Hoffman, A. R. (1998) · PubMed · Cited by 495 · see citing works
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Nandakumar, J., Bell, C., Weidenfeld, I., Zaug, A. J., Leinwand, L. A., & Cech, T. R. (2012) · Nature · doi:10.1038/nature11648 · Cited by 351 · see citing works
The Role of MicroRNAs in Colorectal Cancer
Schetter, A. J., Okayama, H., & Harris, C. C. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318258b78f · Cited by 309 · see citing works
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
Hackett, J. A., & Greider, C. W. (2002) · Oncogene · doi:10.1038/sj.onc.1205061 · Cited by 245 · see citing works
Kaste, S. C., Pratt, C. B., Cain, A. M., Jones-Wallace, D., & Rao, B. N. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19991015)86:8 · Cited by 212 · see citing works
Engelhardt, M. M., Drullinsky, P. R., Guillem, J. G., & Moore, M. A. S. (1997) · PubMed · Cited by 189 · see citing works
Bechter, O. E., Zou, Y. S., Walker, W., Wright, W. E., & Shay, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0323 · Cited by 184 · see citing works
Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Friederichs, J., Hoos, A., Werner, M., Ulm, K., Holzmann, B., Nekarda, H., & Siewert, J.-R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.160 · Cited by 180 · see citing works
Yong, F. L., Law, C. W., & Wang, C. W. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-280 · Cited by 176 · see citing works
hTERT antagonizes p53-induced apoptosis independently of telomerase activity
Rahman, R., Latonen, L., & Wiman, K. G. (2004) · Oncogene · doi:10.1038/sj.onc.1208232 · Cited by 157 · see citing works
Haendeler, J., Hoffmann, J., Rahman, S., Zeiher, A. M., & Dimmeler, S. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00058-9 · Cited by 154 · see citing works
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
Bufalo, D. D., Rizzo, A., Trisciuoglio, D., Cardinali, G., Torrisi, M. R., Zangemeister‐Wittke, U., Zupi, G., & Biroccio, A. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401670 · Cited by 140 · see citing works
Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J. W., Matsuura, Y., & Yokoyama, T. (2000) · PubMed · Cited by 132 · see citing works
Rampazzo, E., Bertorelle, R., Serra, L., Terrin, L., Candiotto, C., Pucciarelli, S., Bianco, P. D., Nitti, D., & De Rossi, A. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605644 · Cited by 125 · see citing works
Self-citationAssays for human telomerase activity: progress and prospects
Zhou, X., & Xing, D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35045a · Cited by 118 · see citing works
Jones, A. M., Beggs, A. D., Carvajal-Carmona, L., Farrington, S., Tenesa, A., Walker, M., Howarth, K., Ballereau, S., Hodgson, S. V., Zauber, A., et al. (2012) · Gut · doi:10.1136/gut.2011.239772 · Cited by 113 · see citing works
Schiemann, U., Kellner, H., & Gross, M. (2004) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2004-812996 · Cited by 112 · see citing works
Garcia‐Aranda, C., de Juan, C., Diaz‐Lopez, A., Sanchez‐Pernaute, A., Torres, A., Diaz‐Rubio, E., Balibrea, J., Benito, M., & Iniesta, P. (2006) · Cancer · doi:10.1002/cncr.21625 · Cited by 105 · see citing works
Sæbøe‐Larssen, S., Fossberg, E., & Gaudernack, G. (2006) · BMC Molecular Biology · doi:10.1186/1471-2199-7-26 · Cited by 99 · see citing works
Roger, L., Jones, R. E., Heppel, N. H., Williams, G. T., Sampson, J. R., & Baird, D. M. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt191 · Cited by 97 · see citing works
Short Telomeres in ESCs Lead to Unstable Differentiation
Pucci, F., Gardano, L., & Harrington, L. A. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.01.018 · Cited by 91 · see citing works
Terrin, L., Rampazzo, E., Pucciarelli, S., Agostini, M., Bertorelle, R., Esposito, G., DelBianco, P., Nitti, D., & De Rossi, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0478 · Cited by 91 · see citing works
Self-citationBurstein, H. J., & Schwartz, R. S. (2008) · New England Journal of Medicine · doi:10.1056/nejme0800065 · Cited by 89 · see citing works
Epidemiologic evidence for a role of telomere dysfunction in cancer etiology
Prescott, J., Wentzensen, I. M., Savage, S. A., & Vivo, I. D. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.06.009 · Cited by 86 · see citing works
Telomere Length in the Colon Declines with Age: a Relation to Colorectal Cancer?
O'Sullivan, J. N., Risques, R. A., Mandelson, M. T., Chen, L., Brentnall, T. A., Bronner, M. P., MacMillan, M. P., Feng, Z., Siebert, J. R., Potter, J. D., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0542 · Cited by 78 · see citing works
Bertorelle, R., Briarava, M., Rampazzo, E., Biasini, L., Agostini, M., Maretto, I., Lonardi, S., Friso, M. L., Mescoli, C., Zagonel, V, et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.602 · Cited by 77 · see citing works
Self-citationPlentz, R. R., Wiemann, S. U., Flemming, P., Meier, P. N., Kubicka, S., Kreipe, H., Manns, M. P., & Rudolph, K. L. (2003) · Gut · doi:10.1136/gut.52.9.1304 · Cited by 71 · see citing works
Pucciarelli, S., Rampazzo, E., Briarava, M., Maretto, I., Agostini, M., Digito, M., Keppel, S., Friso, M. L., Lonardi, S., Paoli, A. D., et al. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2272-z · Cited by 70 · see citing works
Correlation of telomere lengths in normal and cancers tissue in the large bowel
Nakamura, K. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00521-8 · Cited by 68 · see citing works
Terrin, L., Trentin, L., Degan, M., Corradini, I., Bertorelle, R., Carli, P., Maschio, N., Bo, M. D., Noventa, F., Gattei, V., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404607 · Cited by 64 · see citing works
Self-citationRaynaud, C. M., Jang, S. J., Nuciforo, P. G., Lantuéjoul, S., Brambilla, E. M., Mounier, N., Olaussen, K. A., André, F., Morat, L., Sabatier, L., et al. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn405 · Cited by 62 · see citing works
Lledó, S., García‐Granero, E., Dası́, F., Ripoli, R., García, S. A., Cervantes, A. M. R., & Aliño, S. F. (2004) · Colorectal Disease · doi:10.1111/j.1463-1318.2004.00627.x · Cited by 60 · see citing works
Cui, Y., Cai, Q., Qu, S., Chow, W., Wen, W., Xiang, Y.-B., Wu, J., Rothman, N., Yang, G., Shu, X., et al. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0657 · Cited by 59 · see citing works
Kin, C., Kidess, E., Poultsides, G. A., Visser, B. C., & Jeffrey, S. S. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.811896 · Cited by 58 · see citing works
Jin, X., Beck, S. J., Sohn, Y.-W., Kim, J.-K., Kim, S.-H., Yin, J., Pian, X., Kim, S.-C., Choi, Y.-J., & Kim, H. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.8.058 · Cited by 50 · see citing works
Telomerase Detection in Body Fluids
Hess, J. L., & Highsmith, W. E. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.1.18 · Cited by 50 · see citing works
Telomere length is a prognostic factor for overall survival in colorectal cancer
Valls, C., Piñol, C., Reñé, J. M., Buenestado, J., & Viñas, J. (2010) · Colorectal Disease · doi:10.1111/j.1463-1318.2010.02433.x · Cited by 44 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Werner, M., Laßmann, S., Ulm, K., Nekarda, H., & Siewert, J. R. (2002) · Cancer · doi:10.1002/cncr.10939 · Cited by 43 · see citing works
Quantitative analysis of hTERT mRNA expression in colorectal cancer
Niiyama, H., Mizumoto, K., Sato, N., Nagai, E., Mibu, R., Fukui, T., Kinoshita, M., & Tanaka, M. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03890.x · Cited by 42 · see citing works
Lopez (2002) · doi:10.1002/cncr.10911 · Cited by 36 · see citing works
Evaluation of telomerase in the development and progression of colon cancer
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Quirico, D. D., Donati, V. L., Berti, P., Spisni, R., Galleri, D., Materazzi, G., et al. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.10.5.589 · Cited by 36 · see citing works
Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells
Méndez-Bermúdez, A., & Royle, N. J. (2011) · Human Mutation · doi:10.1002/humu.21522 · Cited by 36 · see citing works
Tao, S. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i19.2334 · Cited by 34 · see citing works
Dolcetti, R., & Rossi, A. D. (2010) · Medicinal Research Reviews · doi:10.1002/med.20211 · Cited by 33 · see citing works
Katayama, S., Shiota, G., Oshimura, M., & Kawasaki, H. (1999) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050294 · Cited by 31 · see citing works
Telomerase Activity as a Prognostic Factor in Colorectal Cancer
Casla, M. T. S., Vidaurreta, M., Sanchez-Rueda, D., Maestro, M. L., Arroyo, M., & Cerdán, F. J. (2005) · Oncology Research and Treatment · doi:10.1159/000088525 · Cited by 29 · see citing works
Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer
Valls, C., Felis, C. P., Espinet, J. M. R., García, J. B., & Salas, J. V. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0820-y · Cited by 29 · see citing works
Naito, Y., Takagi, T., Handa, O., Ishikawa, T., Matsumoto, N., Yoshida, N., Kato, H., Ando, T., Takemura, T., Itani, K., et al. (2001) · Tumor Biology · doi:10.1159/000050640 · Cited by 25 · see citing works
Telomere Length and Genetic Anticipation in Lynch Syndrome
Seguí, N., Pineda, M., Guinó, E., Borràs, E., Navarro, M., Bellido, F., Moreno, V. R., Lázaro, C., Blanco, I., Capellá, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061286 · Cited by 25 · see citing works
Relationship between microsatellite instability and telomere shortening in colorectal cancer
Takagi, S., Kinouchi, Y., Hiwatashi, N., Nagashima, F., Chida, M., Takahashi, S., Negoro, K., Shimosegawa, T., & Toyota, T. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02237220 · Cited by 24 · see citing works
Telomerase as a diagnostic and predictive marker in colorectal carcinoma.
Maláska, J., Kunická, Z., Borský, M., Skleničková, M., Novotna, M., Fajkusová, L., Žaloudík, J., & Fajkus, J. (2004) · PubMed · Cited by 23 · see citing works
Vidaurreta, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i28.3868 · Cited by 19 · see citing works
Ghori, A., Usselmann, B., Ferryman, S. R., Morris, A. G., & Fraser, I. A. (2002) · Colorectal Disease · doi:10.1046/j.1463-1318.2002.00378.x · Cited by 17 · see citing works
Regulation of telomerase and its hTERT messenger in colorectal cancer
Boldrini, L., Faviana, P., Gisfredi, S., et al. (2004) · Oncology Reports · doi:10.3892/or.11.2.395 · Cited by 17 · see citing works
Telomerase activity and telomere length in the colorectal polyp-carcinoma sequence
Valls, C., Felis, C. P., Espinet, J. M. R., García, J. B., & Salas, J. V. (2009) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082009000300004 · Cited by 16 · see citing works
Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes
Shawi, M., Chu, T. W., Marignac, V. L. M., Yu, Y., Gryaznov, S. M., Johnston, J. B., Lees‐Miller, S. P., Assouline, S. E., Autexier, C., & Aloyz, R. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070428 · Cited by 15 · see citing works
Kojima, K., Hiyama, E., Otani, K., Ohtaki, M., Fukuba, I., Fukuda, E., Sueda, T., & Hiyama, K. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01786.x · Cited by 14 · see citing works
Predictive Value of Microsatellite Instability-High Remains Controversial
Kim, G. P., Colangelo, L. H., Paik, S., O’Connell, M. J., Kirsch, I. R., Allegra, C. J., & Wolmark, N. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.2019 · Cited by 12 · see citing works
Safont, M. J., Gil-Raga, M., Sirera, R., Lewintre, E. J., Sanmartín, E., Gallach, S., Caballero, C., del Pozo, N., Palomares, E., & Camps, C. (2011) · Clinical & Translational Oncology · doi:10.1007/s12094-011-0673-2 · Cited by 10 · see citing works
Beyond KRAS: a new approach in metastatic colorectal cancer
Winder, T., & Lenz, H. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70147-9 · Cited by 5 · see citing works
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Prasad, K. N., Wu, M., & Bondy, S. C. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.04.004 · Cited by 115 · see citing works
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Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Telomeres and telomerase in the clinical management of colorectal cancer
Piñol-Felis, C., Fernández-Marcelo, T., Viñas-Salas, J., & Valls-Bautista, C. (2017) · Clinical and Translational Oncology · doi:10.1007/s12094-016-1559-0 · Cited by 13 · see citing works
- Authors
- Bertorelle, R.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Bertorelle, Roberta
- ORCID
- Bertorelle, Roberta
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 8
- Pages
- 1940
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3934464
- OpenAlex
- W1993934102
- Cited by
- 82
- References
- 88
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 12 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 5 · 2014: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc)
- World Journal of Gastroenterology
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- colorectal cancer, telomeres, telomerase, telomerase reverse transcriptase, chromosomal instability, replicative senescence, APC gene, telomere length, prognostic factors, disease progression monitoring, carcinogenesis
- MeSH terms
- Cell Transformation, Neoplastic, Chromosomes, DNA, Humans, Prognosis, Biomarkers, Tumor, Colorectal Neoplasms, Telomere, Treatment Outcome, Cellular Senescence, Disease Progression, Telomerase, Chromosomal Instability, Epigenesis, Genetic, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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