Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis
Open accessAbstract
BACKGROUND: Telomeres, repetitive DNA capping ends of eukaryotic chromosomes, are important in the maintenance of genomic integrity. Perturbed telomeres are common features of many human malignancies, including colorectal cancer. METHODS: Telomere length (TL), measured by a Monochrome Multiplex Real-Time qPCR, was investigated in tumour tissues, adjacent mucosa, and blood from patients with colorectal cancer with different clinicopathological features and its impact on patient survival. TL was also measured in a limited number of liver metastases, non-cancerous liver tissues or corresponding tissues from the same patients. RESULTS: TL in tumour tissues was shorter than in the adjacent mucosa (P < 0.0001). Shorter TL was observed in tumours with lower stage than in those with advanced stages (P = 0.001). TL was shorter in tumours at the proximal than at the distal sites of the colon (P < 0.0001). Shorter TL was also associated with microsatellite instability (P = 0.001) and mucinous tumour histology (P < 0.0001). Patients with a smaller TL ratio between tumour tissues and the adjacent mucosa were associated with increased overall survival (P = 0.022). Metastasised tumours had shorter telomeres than the adjacent non-cancerous liver tissues (P = 0.0005). CONCLUSIONS: Overall, the results demonstrate differences in TL between tumours and the adjacent mucosa, between tumours located at different sites and association with patient survival.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent studies on CRC have revealed that telomere length from malignant cells tends to be shorter than in neighboring healthy mucosa.
“Recent studies on CRC have revealed that TL from malignant cells tends to be shorter than in neighboring “healthy” mucosa [194].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [194]
The clinical stage of CRC malignancy seems to be correlated with telomere length; cancers at lower stages tend to have shorter telomeres in contrast to advanced and metastatic cancers.
“Additionally, the clinical stage of the malignancy seems to be correlated with TL. In fact, cancers at lower stages tend to have shorter telomeres in contrast to advanced and metastatic cancers [194].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [194]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112797 · Cited by 16,303 · see citing works
Clues to the Pathogenesis of Familial Colorectal Cancer
Aaltonen, L. A., Peltomäki, P., Leach, F. S., Sistonen, P., Pylkkänen, L., Mecklin, J., Järvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., et al. (1993) · Science · doi:10.1126/science.8484121 · Cited by 2,709 · see citing works
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works
Telomere length measurement by a novel monochrome multiplex quantitative PCR method
Cawthon, R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1027 · Cited by 1,417 · see citing works
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 992 · see citing works
POT1 as a terminal transducer of TRF1 telomere length control
Loayza, D., & de Lange, T. (2003) · Nature · doi:10.1038/nature01688 · Cited by 696 · see citing works
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features
Missiaglia, E., Jacobs, B., D’Ario, G., Narzo, A. F. D., Soneson, C., Budínská, E., Popovici, V. C., Vecchione, L., Gerster, S., Yan, P., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu275 · Cited by 646 · see citing works
Mechanism of telomere shortening by oxidative stress
KAWANISHI, S., & OIKAWA, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.047 · Cited by 522 · see citing works
Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer
Carethers, J. M., & Jung, B. H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.047 · Cited by 483 · see citing works
Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis
Walther, A., Houlston, R. S., & Tomlinson, I. P. M. (2008) · Gut · doi:10.1136/gut.2007.135004 · Cited by 368 · see citing works
Paschke, S., Jafarov, S., Staib, L., Kreuser, E.-D., Maulbecker-Armstrong, C. C., Roitman, M., Holm, T., Harris, C. C., Link, K.-H., & Kornmann, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092577 · Cited by 251 · see citing works
Colorectal cancer: a tale of two sides or a continuum?: Figure 1
Yamauchi, M., Lochhead, P. J., Morikawa, T., Huttenhower, C., Chan, A. T., Giovannucci, E. L., Fuchs, C. S., & Ogino, S. (2012) · Gut · doi:10.1136/gutjnl-2012-302014 · Cited by 250 · see citing works
TERT promoter mutations in telomere biology
Heidenreich, B., & Kumar, R. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.11.002 · Cited by 198 · see citing works
Self-citationGrady, W. M., & Markowitz, S. D. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3444-4 · Cited by 193 · see citing works
Stewénius, Y., Gorunova, L., Jonson, T., Larsson, N., Höglund, M., Mandahl, N., Mertens, F., Mitelman, F., & Gisselsson, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408454102 · Cited by 183 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Friederichs, J., Hoos, A., Werner, M., Ulm, K., Holzmann, B., Nekarda, H., & Siewert, J.-R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.160 · Cited by 180 · see citing works
Rampazzo, E., Bertorelle, R., Serra, L., Terrin, L., Candiotto, C., Pucciarelli, S., Bianco, P. D., Nitti, D., & De Rossi, A. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605644 · Cited by 125 · see citing works
Beginning at the ends: telomeres and human disease
Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works
Garcia‐Aranda, C., de Juan, C., Diaz‐Lopez, A., Sanchez‐Pernaute, A., Torres, A., Diaz‐Rubio, E., Balibrea, J., Benito, M., & Iniesta, P. (2006) · Cancer · doi:10.1002/cncr.21625 · Cited by 105 · see citing works
Telomere Length in the Colon Declines with Age: a Relation to Colorectal Cancer?
O'Sullivan, J. N., Risques, R. A., Mandelson, M. T., Chen, L., Brentnall, T. A., Bronner, M. P., MacMillan, M. P., Feng, Z., Siebert, J. R., Potter, J. D., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0542 · Cited by 78 · see citing works
Telomere length, telomerase reverse transcriptase promoter mutations, and melanoma risk
Rachakonda, P. S., Kong, H.-Y., Srinivas, N., García‐Casado, Z., Requena, C., Fallah, M., Heidenreich, B., Planelles, D., Traves, V., Schadendorf, D., et al. (2018) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22669 · Cited by 50 · see citing works
Self-citationTelomere length is a prognostic factor for overall survival in colorectal cancer
Valls, C., Piñol, C., Reñé, J. M., Buenestado, J., & Viñas, J. (2010) · Colorectal Disease · doi:10.1111/j.1463-1318.2010.02433.x · Cited by 44 · see citing works
Boardman, L. A., Johnson, R., Viker, K., Hafner, K. A., Jenkins, R. B., Riegert‐Johnson, D. L., Smyrk, T. C., Litzelman, K., Seo, S., Gangnon, R. E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080015 · Cited by 39 · see citing works
Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients
Benitéz‐Buelga, C., Sánchez, L. M. M., Gallardo, M., Apellániz-Ruiz, M., Inglada‐Pérez, L., Yanowsky, K., Carrillo, J., García‐Estévez, L., Calvo, I., Perona, R., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3246-6 · Cited by 34 · see citing works
Katayama, S., Shiota, G., Oshimura, M., & Kawasaki, H. (1999) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050294 · Cited by 31 · see citing works
Telomere length and survival in primary cutaneous melanoma patients
Rachakonda, P. S., Srinivas, N., Mahmoudpour, S. H., García‐Casado, Z., Requena, C., Traves, V., Soriano, V., Cardelli, M., Pjanova, D., Molven, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29322-9 · Cited by 30 · see citing works
Self-citationTelomere length, arsenic exposure and risk of basal cell carcinoma of skin
Srinivas, N., Rachakonda, P. S., Hielscher, T., Calderazzo, S., Rudnai, P., Gurzau, E. S., Koppová, K., Fletcher, T., & Kumar, R. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz059 · Cited by 27 · see citing works
Self-citationSuraweera, N., Mouradov, D., Li, S., Jorissen, R. N., Hampson, D., Ghosh, A., Sengupta, N., Thaha, M. A., Ahmed, S., Kirwan, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9015 · Cited by 25 · see citing works
Relationship between microsatellite instability and telomere shortening in colorectal cancer
Takagi, S., Kinouchi, Y., Hiwatashi, N., Nagashima, F., Chida, M., Takahashi, S., Negoro, K., Shimosegawa, T., & Toyota, T. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02237220 · Cited by 24 · see citing works
Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis
Balc’h, E. L., Grandin, N., Demattei, M.-V., Guyétant, S., Tallet, A., Pagès, J., Ouaïssi, M., Lecomte, T., & Charbonneau, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091871 · Cited by 21 · see citing works
Kroupa, M., Polívková, Z., Rachakonda, P. S., Schneiderová, M., Vodenková, S., Büchler, T., Jirásková, K., Urbanova, M., Vodičková, Ľ., Hemminki, K., et al. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22508 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Telomerase in Cancer: Function, Regulation, and Clinical Translation
Robinson, N. J., & Schiemann, W. P. (2022) · Cancers · doi:10.3390/cancers14030808 · Cited by 95 · see citing works
Role of telomere length in human carcinogenesis (Review)
Tsatsakis, A. M., Oikonomopoulou, T., Νikolouzakis, Τ. Κ., Vakonaki, E., Tzatzarakis, M. N., Flamourakis, M., Renieri, E. A., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., et al. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5526 · Cited by 58 · see citing works
Colorectal Adenomas—Genetics and Searching for New Molecular Screening Biomarkers
Siskova, A., Červená, K., Král, J., Hucl, T., Vodička, P., & Vymetalkova, V. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093260 · Cited by 52 · see citing works
Self-citationCurrent and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Jedidi, S., Sammari, H., Selmi, H., Hosni, K., Rtibi, K., Aloui, F., Adouni, O., & Sebaï, H. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104406 · Cited by 26 · see citing works
Dinami, R., Porru, M., Amoreo, C. A., Sperduti, I., Mottolese, M., Buglioni, S., Marinelli, D., Maugeri‐Saccà, M., Sacconi, A., Blandino, G., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01612-z · Cited by 23 · see citing works
Seo, S., Shin, J., Ham, D.-W., & Shin, E. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113366 · Cited by 19 · see citing works
Goncalves, T., Zoumpoulidou, G., Alvarez-Mendoza, C., Mancusi, C., Collopy, L. C., Strauss, S. J., Mittnacht, S., & Tomita, K. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00125 · Cited by 15 · see citing works
Kibriya, M. G., Raza, M., Kamal, M., Haq, Z., Paul, R., Mareczko, A., Pierce, B. L., Ahsan, H., & Jasmine, F. (2022) · Cancers · doi:10.3390/cancers14092250 · Cited by 17 · see citing works
Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer
Tomášová, K., Kroupa, M., Försti, A., Vodička, P., & Vodičková, Ľ. (2020) · Mutagenesis · doi:10.1093/mutage/geaa005 · Cited by 17 · see citing works
Self-citationMutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
Jungwirth, J., Urbanova, M., Boot, A., Hošek, P., Bendová, P., Siskova, A., Švec, J., Kment, M., Tumova, D., Summerova, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-06498-9 · Cited by 14 · see citing works
Self-citationKroupa, M., Rachakonda, S. P., Vymetalkova, V. P., Tomášová, K., Liška, V., Vodenková, S., Čumová, A., Rössnerová, A., Vodičková, Ľ., Hemminki, K., et al. (2020) · Mutagenesis · doi:10.1093/mutage/geaa030 · Cited by 14 · see citing works
Self-citationTelomere Length as a New Risk Marker of Early-Onset Colorectal Cancer
Martel-Martel, A., Corchete, L. A., Martí, M., Tocino, R. V., Hurtado, E., Álvaro, E., Jiménez, F., Jiménez‐Toscano, M., Balaguer, F., Sanz, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043526 · Cited by 13 · see citing works
Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers
Jung, S.-J., Seo, Y.-R., Park, W.-J., Heo, Y.-R., Lee, Y., Kim, S., & Lee, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s274394 · Cited by 13 · see citing works
Vodička, P., Vodenková, S., Horak, J., Opattová, A., Tomášová, K., Vymetalkova, V. P., Štětina, R., Hemminki, K., & Vodičková, Ľ. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503564 · Cited by 12 · see citing works
Self-citationPauleck, S., Sinnott, J. A., Zheng, Y., Gadalla, S. M., Viskochil, R. H., Haaland, B. A., Cawthon, R., Hoffmeister, A., & Hardikar, S. S. (2023) · Cancers · doi:10.3390/cancers15041159 · Cited by 12 · see citing works
The dynamics of telomere length in primary and metastatic colorectal cancer lesions
Kroupa, M., Kubecek, O., Tomasova, K., Hanak, P., Krupova, M., Cervena, K., Siskova, A., Rosendorf, J., Hosek, P., Vodickova, L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35835-9 · Cited by 10 · see citing works
Self-citationTelomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer
Loukopoulou, C., Νikolouzakis, Τ. Κ., Koliarakis, I., Vakonaki, E., & Tsiaoussis, J. (2024) · Cancers · doi:10.3390/cancers16193370 · Cited by 13 · see citing works
Pauleck, S., Gigic, B., Cawthon, R., Ose, J., Peoples, A. R., Warby, C. A., Sinnott, J. A., Lin, T., Boehm, J., Schrotz‐King, P., et al. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2021.12.008 · Cited by 11 · see citing works
Byrjalsen, A., Brainin, A. E., Lund, T. K., Andersen, M. K., & Jelsig, A. M. (2023) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-023-00251-7 · Cited by 10 · see citing works
Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
Vodenková, S., Kroupa, M., Polívková, Z., Mušák, Ľ., Ambruš, M., Schneiderová, M., Koževnikovová, R., Vodičková, Ľ., Rachakonda, S. P., Hemminki, K., et al. (2020) · Oncology Reports · doi:10.3892/or.2020.7774 · Cited by 10 · see citing works
Self-citationTelomere-related gene risk model for prognosis prediction in colorectal cancer
Chen, H., Pan, Y., Lv, C., He, W. W., Wu, D., & Xuan, Q. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-43 · Cited by 9 · see citing works
Telomere in colorectal cancer associated with distant metastases and predicted a poor prognosis
Ye, X., Li, J., Song, C., & Chen, W. (2021) · Translational Cancer Research · doi:10.21037/tcr-20-3341 · Cited by 8 · see citing works
Nogueira, B. M. D., Pantoja, L. D. C., da Silva, E. L., Júnior, F. A. R. M., Teixeira, E. B., Wanderley, A. V., Maués, J. H. D. S., de Moraes, M. O., de Moraes, M. E. A., Montenegro, R. C., et al. (2021) · Genes · doi:10.3390/genes12101632 · Cited by 8 · see citing works
Cellular Senescence: a Promising Therapeutic Target in Colorectal Cancer
Wu, Y., Xie, M., Sun, J., Li, C., Dong, G., Zhang, Q.-S., & Cui, P. (2022) · Future Oncology · doi:10.2217/fon-2021-0661 · Cited by 8 · see citing works
Feng, J., Tang, X., Song, L., Zhou, Z., Jiang, Y., & Huang, Y. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04456-6 · Cited by 5 · see citing works
Falcinelli, M., Dell’Omo, G., Grassi, E., Mariella, E., Leto, S. M., Scardellato, S., Lorenzato, A., Arena, S., Bertotti, A., Trusolino, L., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05640-3 · Cited by 5 · see citing works
Tomášová, K., Kroupa, M., Zinková, A., Korabečná, M., Vymetalkova, V. P., Škrobánek, P., Sojka, L., Levý, M., Hemminki, K., Liška, V., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.962929 · Cited by 5 · see citing works
Self-citationTomášová, K., Šeborová, K., Kroupa, M., Horak, J., Kavec, M., Vodičková, Ľ., Rob, L., Hruda, M., Mrhalová, M., Bartáková, A., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33525 · Cited by 4 · see citing works
Self-citationEditorial: Current understanding of genomic and chromosomal instabilities in solid malignancies
Vodička, P., Kroupa, M., Vodičková, Ľ., & Kumar, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1245087 · Cited by 3 · see citing works
Self-citationTelomerase: A link between cancer and biological immortality
Prathibha, S. S., Rhythima, K., Alag, R., Singh, S., & Alwal, S. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.16.2.1249 · Cited by 2 · see citing works
Uttarilli, A., Balounová, K., Tomášová, K., Hanák, P., Saskova, K., Vodička, P., Vodičková, L., Hemminki, K., Lubinski, J., & Kroupa, M. (2026) · Discover Oncology · doi:10.1007/s12672-025-04007-8 · Cited by 2 · see citing works
Self-citationSaskova, K., Landfors, M., Hlaváč, V., Šeborová, K., Brůha, J., Honkova, K., Tomášová, K., Selvi, S., Drábová, J., Hackenhaar, F. S., et al. (2026) · Mutagenesis · doi:10.1093/mutage/geag010 · Cited by 1 · see citing works
Self-citationValickova, A., Tomášová, K., Balounová, K., Horak, J., Kroupa, M., Hanák, P., Danesova, N., Jungwirth, J., Král, J., Hucl, T., et al. (2026) · Mutagenesis · doi:10.1093/mutage/geag009 · Cited by 1 · see citing works
Self-citationGil-Korilis, A., Ergui-Arbizu, J., Hanák, P., Danesova, N., Tomášová, K., Valickova, A., Horak, J., Gentiluomo, M., Levý, M., Křivonosková, S., et al. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01423-6 · Cited by 1 · see citing works
Self-citationGan, W., Pei, X., Yang, G., Zheng, G., Pan, Y., & Hu, P. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101174 · Cited by 1 · see citing works
Tang, S., Yao, X., Wang, S., Zhu, F., Zeng, W., Lai, D., Meng, X., Zhang, X., Zhu, Z., Zhang, T., et al. (2026) · Inflammation Research · doi:10.1007/s00011-026-02257-y · Cited by 1 · see citing works
Vodičková, Ľ., Horak, J., & Vodička, P. (2022) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-1340 · Cited by 1 · see citing works
Han, S., Min, J., Kim, D.-K., Kong, I. D., & Kim, N. (2023) · Korean Journal of Adult Nursing · doi:10.7475/kjan.2023.35.1.1 · Cited by 1 · see citing works
A novel machine learning approach for tumor detection based on telomeric signatures
Shah, P., & Sethuraman, A. (2025) · Biology Methods and Protocols · doi:10.1093/biomethods/bpaf069 · Cited by 1 · see citing works
Derenzini, E., Gueli, A., Risso, A., Bruna, R., Gottardi, D., Cignetti, A., Pileri, S. A., Avvedimento, E. V., & Tarella, C. (2022) · Hematological Oncology · doi:10.1002/hon.3118
- Authors
- Kroupa, M., Rachakonda, S. K., Liska, V., Srinivas, N., Urbanova, M., Jiraskova, K., Schneiderova, M., Vycital, O., Vymetalkova, V., Vodickova, L., Kumar, R., & Vodicka, P.
- Affiliations
- Czech Academy of Sciences (CZ)
- German Cancer Research Center (DE)
- Corresponding author
- Kroupa, Michal
- Venue
- British Journal of Cancer
- Published
- 2019-07-17
- Volume
- 121
- Issue
- 4
- Pages
- 344-350
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC6738117
- OpenAlex
- W2958346341
- Cited by
- 41
- References
- 31
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 3 · 2020: 7
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Grantová Agentura České Republiky (15-27580A, GA18-09709S)
- Ministerstvo Zdravotnictví Ceské Republiky (NV19-09-00237, AZV 15-27580A, LO1503, AZV 15-, AZV 17- 30920A, 15-27580A, NV18-03-00199, UNCE/MED/006, 17-30920A)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- telomere length, colorectal cancer, cancer phenotypes, prognosis, overall survival, microsatellite instability, liver metastasis, tumor stage, genomic instability
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Phenotype, Prognosis, Colorectal Neoplasms, Telomere, Microsatellite Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
