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Cited by 171Enzyme Structure and FunctionPorphyrin Metabolism and DisordersProtein Structure and Dynamics

Structure and activity of tryptophan-rich TSPO proteins

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Guo, Youzhong, Kalathur, Ravi C., Liu, Qun, Kloss, Brian, Bruni, Renato, Ginter, Christopher, Kloppmann, Edda, Rost, Burkhard +1 more·2015·Science
DOI 10.1126/science.aaa1534PMC PMC4341906
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Abstract

Structural clues to protein function: Translocator protein (TSPO) is a mitochondrial membrane protein thought to transport cholesterol and porphyrins. Its detailed function remains unclear, but interest in it is high because TSPO is involved in a variety of human diseases. Two papers now present crystal structures of bacterial TSPOs. Li et al. show that a mutant that mimics a human single polymorphism associated with psychiatric disorders has structural changes in a region implicated in cholesterol binding. Guo et al. suggest that TSPO may be more than a transporter. They show how it catalyzes the degradation of porphyrins, a function that could be important in protection against oxidative stress. Science , this issue p. 555 , p. 551

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Authors
Guo, Y., Kalathur, R. C., Liu, Q., Kloss, B., Bruni, R., Ginter, C., Kloppmann, E., Rost, B., & Hendrickson, W. A.
Affiliations
  • Columbia University (US)
  • New York Structural Biology Center (US)
  • Brookhaven National Laboratory (US)
Corresponding author
Hendrickson, Wayne A.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-01-30
Volume
347
Issue
6221
Pages
551-555
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaa1534
PMC
PMC4341906
OpenAlex
W1900110634
Cited by
171
References
0
Citations by year
2026: 4 · 2025: 7 · 2024: 15 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 21 · 2019: 13 · 2018: 11 · 2017: 19 · 2016: 17 · 2015: 32
FWCI
10.96
Type
journal article
Language
en
Open access
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (GM095315, GM107462)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
translocator protein (TSPO), PK11195, crystal structure, antioxidant defense
MeSH terms
Amino Acid Sequence, Bacillus cereus, Bacterial Proteins, Binding Sites, Isoquinolines, Ligands, Molecular Sequence Data, Protein Conformation, Protoporphyrins, Tryptophan, Reactive Oxygen Species, Protein Structure, Secondary, Crystallography, X-Ray, Protein Subunits, Membrane Transport Proteins, Mutant Proteins, Protein Multimerization

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