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Cited by 675

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

Open access
Lo, Bernice, Zhang, Kejian, Lu, Wei, Zheng, Lixin, Zhang, Qian, Kanellopoulou, Chrysi, Zhang, Yu, Liu, Zhiduo, Fritz, Jill M., Marsh, Rebecca, Husami, Ammar, Kissell, Diane, Nortman, Shannon, Chaturvedi, Vijaya, Haines, Hilary, Young, Lisa R., Mo, Jun, Filipovich, Alexandra H., Bleesing, Jack J., Mustillo, Peter, Stephens, Michael, Rueda, Cesar M., Chougnet, Claire A., Hoebe, Kasper, McElwee, Joshua, Hughes, Jason D., Karakoc-Aydiner, Elif, Matthews, Helen F., Price, Susan, Su, Helen C., Rao, V. Koneti, Lenardo, Michael J., Jordan, Michael B.·2015·Science
DOI 10.1126/science.aaa1663
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Abstract

Trafficking from bedside to bench: Typically in translational research, a discovery in cell or molecular biology is later exploited to improve patient care. Occasionally, information flows in the opposite direction. Lo et al. found that patients with an autoimmune disorder caused by deficiency of a protein called LRBA responded dramatically to the drug abatacept (see the Perspective by Sansom). Abatacept contains a segment of a potent inhibitory immune receptor, CTLA4. Experiments prompted by this observation revealed the relationship between the two proteins: LRBA controls the intracellular trafficking and degradation of CTLA4. This information may further improve patient care, because other clinically approved drugs have the desired mechanism of action with potentially fewer side effects. Science , this issue p. 436 ; see also p. 377

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Metadata

Authors
Lo, B., Zhang, K., Lu, W., Zheng, L., Zhang, Q., Kanellopoulou, C., Zhang, Y., Liu, Z., Fritz, J. M., Marsh, R., Husami, A., Kissell, D., Nortman, S., Chaturvedi, V., Haines, H., Young, L. R., Mo, J., Filipovich, A. H., Bleesing, J. J., Mustillo, P., Stephens, M., Rueda, C. M., Chougnet, C. A., Hoebe, K., McElwee, J., Hughes, J. D., Karakoc-Aydiner, E., Matthews, H. F., Price, S., Su, H. C., Rao, V. K., Lenardo, M. J., & Jordan, M. B.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-07-24
Volume
349
Issue
6246
Pages
436-440
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaa1663
OpenAlex
W1574766328
Cited by
675
References
26
FWCI
24.60
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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