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Cited by 306Neural dynamics and brain functionVisual perception and processing mechanismsNeural and Behavioral Psychology Studies

Single-trial spike trains in parietal cortex reveal discrete steps during decision-making

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Latimer, Kenneth W., Yates, Jacob L., Meister, Miriam L. R., Huk, Alexander C., Pillow, Jonathan W.·2015·Science
DOI 10.1126/science.aaa4056PMC PMC4799998
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Abstract

A better way to explain neuronal activity: A brain region called the lateral intraparietal (LIP) area is involved in primate decision-making. The dominant model to explain neuronal firing in LIP assumes that neurons slowly accumulate sensory evidence in favor of one choice or another. Latimer et al. hypothesized that neurons instead exhibit rapid steps or jumps in their firing rate, reflecting discrete changes in the animal's decision state. They recorded from LIP neurons in macaque monkeys performing a motion-discrimination task. LIP spike trains in most cells involved discrete stepping dynamics rather than slow evidence integration dynamics. Science , this issue p. 184

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  • The trace of the Hessian can measure a layer's sensitivity to quantization.

    “It was theoretically shown that the trace of the second-order operator (i.e., the Hessian) can be used to measure the sensitivity of a layer to quantization [50], similar to results for pruning in the seminal work of Optimal Brain Damage [139].”

    From A Survey of Quantization Methods for Efficient Neural Network Inference (2022) · cites this paper as [139]

    The paper’s discussion of statistical model comparison for macaque spike trains (section labeled Abstract; page unavailable) does not address neural-network layers or their sensitivity to quantization. Searches for the Hessian, quantization, and pruning found no passage supporting the attributed claim. (LLM, conf=0.78)

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Authors
Latimer, K. W., Yates, J. L., Meister, M. L. R., Huk, A. C., & Pillow, J. W.
Affiliations
  • The University of Texas at Austin (US)
  • University of Washington (US)
  • Princeton University (US)
Corresponding author
Pillow, Jonathan W.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-07-10
Volume
349
Issue
6244
Pages
184-187
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaa4056
PMC
PMC4799998
OpenAlex
W2164011442
Cited by
306
References
9
Citations by year
2026: 12 · 2025: 23 · 2024: 26 · 2023: 16 · 2022: 23 · 2021: 26 · 2020: 35 · 2019: 37 · 2018: 35 · 2017: 32 · 2016: 37 · 2015: 4
FWCI
21.64
Type
journal article
Language
en
Open access
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (IIS-1150186)
  • National Institutes of Health
  • National Institute of Mental Health (MH099611)
  • National Institute on Drug Abuse (T32DA018926)
  • National Eye Institute (EY017366, T32EY021462)
  • McKnight Foundation
  • Sloan Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
lateral intraparietal area, decision-making, evidence accumulation, parietal cortex, macaque
MeSH terms
Animals, Choice Behavior, Decision Making, Macaca, Male, Models, Neurological, Neurons, Parietal Lobe

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