Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Yun, Jihye, Mullarky, Edouard, Lu, Changyuan, Bosch, Kaitlyn N., Kavalier, Adam, Rivera, Keith, Roper, Jatin, Chio, Iok In Christine +12 more·2015·Science

DOI 10.1126/science.aaa5004

Cited by (915)

Items 401–500 of 915

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Anja Harej, Andrijana Meščić, Višnja Stepanić, Marko Klobučar, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić‐Malić · 2019 · International Journal of Molecular Sciences
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Advances in the Genetics and Biology of Pancreatic Cancer
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Improving Cold Atmospheric Pressure Plasma Efficacy on Breast Cancer Cells Control-Ability and Mortality Using Vitamin C and Static Magnetic Field
Ramin Mehrabifard, H. Mehdian, Kamal Hajisharifi, Elaheh Amini · 2019 · Plasma Chemistry and Plasma Processing
Vitamin C Inhibits Metastasis of Peritoneal Tumors By Preventing Spheroid Formation in ID8 Murine Epithelial Peritoneal Cancer Model
Yayun Xu, Xing Guo, Ganyu Wang, Changkuo Zhou · 2020 · Frontiers in Pharmacology
Improved Chemotherapy Outcomes of Patients With Small-cell Lung Cancer Treated With Combined Alkalization Therapy and Intravenous Vitamin C
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Glioblastoma Invasiveness and Collagen Secretion Are Enhanced by Vitamin C
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Melatonin‐mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells
Haibo Wu, Chao Song, Jingcheng Zhang, Jiamin Zhao, Beibei Fu, Tingchao Mao, Yong Zhang · 2017 · The FASEB Journal
Inorganic Selenium Induces Nonapoptotic Programmed Cell Death in PC-3 Prostate Cancer Cells Associated with Inhibition of Glycolysis
Jinling Cui, Mingzhu Yan, Xiaoyi Liu, Shutao Yin, Shangyun Lu, Lihong Fan, Hongbo Hu · 2019 · Journal of Agricultural and Food Chemistry
Role of amino acids in regulation of ROS balance in cancer
Emilie Jaune, Sophie Vasseur · 2020 · Archives of Biochemistry and Biophysics
Effects of antioxidants on cancer progression
Sarah Schmidt, Xi Qiao, Martin O. Bergö · 2025 · EMBO Molecular Medicine
Mitochondrial Redox Vulnerabilities in Triple-Negative Breast Cancer: Integrative Perspectives and Emerging Therapeutic Strategies
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Insight into the roles of vitamins C and D against cancer: Myth or truth?
Cai‐Ning Zhao, Ya Li, Xiao Meng, Sha Li, Qing Liu, Guoyi Tang, Ren‐You Gan, Hua‐Bin Li · 2018 · Cancer Letters
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake‐Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart‐Smith, Mark Larance, Veronica F. Sebesfi et al. · 2019 · Redox Biology
Effects of Alkalization Therapy on Chemotherapy Outcomes in Advanced Pancreatic Cancer: A Retrospective Case-Control Study
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SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes
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Anti-colorectal cancer effects of seaweed-derived bioactive compounds
Yunhua Fu, Dong Xie, Yinghao Zhu, Xinyue Zhang, Hao Yue, Kai Zhu, Zifeng Pi, Yulin Dai · 2022 · Frontiers in Medicine
In Situ Silver‐Based Electrochemical Oncolytic Bioreactor
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Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2
Marek Samec, Alena Mazuráková, Vincent Lučanský, Lenka Koklesová, Renata Péčová, Martin Jozef Péč, Olga Golubnitschaja, Raghad Khalid AL-Ishaq, Martin Čaprnda, Ľudovít Gašpar et al. · 2023 · European Journal of Pharmacology
Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell
Lianlian Wang, Xiaofang Luo, Cong Li, Yubing Huang, Ping A. Xu, Laetitia H. Lloyd‐Davies, Thibaut D. J. Delplancke, Chuan Xiao Peng, Rufei Gao, Hongbo Qi et al. · 2017 · Oxidative Medicine and Cellular Longevity
Understanding the Citric Acid–Urea Co–Directed Microwave Assisted Synthesis and Ferric Ion Modulation of Fluorescent Nitrogen Doped Carbon Dots: A Turn On Assay for Ascorbic Acid
J. S. Anjali Devi, Ravindran S. Aparna, B. Aswathy, John Nebu, A. O. Aswathy, Sony George · 2019 · ChemistrySelect
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis
Maria V. Liberti, Annamarie E. Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R. Singleton, Zufeng Guo, Jun O. Liu, Kris C. Wood, Jason W. Locasale · 2019 · Journal of Biological Chemistry
A label-free colorimetric strategy for facile and low-cost sensing of ascorbic acid using MnO 2 nanosheets
Ping Chen, Hui Zhong, Xiang Wang, Changdong Shao, Sanjun Zhi, Xiaorong Li, Chang-Mei Wei · 2019 · Analytical Methods
Research Progress of Warburg Effect in Hepatocellular Carcinoma
Yanguang Yang, Yuting Gao, Yajun Xiong, Yi Gong, Junlan Lu, Yuman Zhang, Dan Wang, Zhihan Liu, Xinli Shi · 2024 · Frontiers in Bioscience-Landmark
ROS-driven and preferential killing of HepG2 over L-02 cells by a short-term cooperation of Cu(II) and a catechol-type resveratrol analog
Fang Dai, Qi Wang, Gui-Juan Fan, Yuting Du, Bo Zhou · 2018 · Food Chemistry
p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies
Anđela Horvat, Ana Tadijan, Ignacija Vlašić, Neda Slade · 2021 · Cancers
Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis
Filippos Kyriakidis, Dionysios Kogias, Theodora Maria Venou, Eleni Karlafti, Daniel Paramythiotis · 2023 · The Application of Clinical Genetics
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Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy
Zain Mehdi, Michael S. Petronek, Jeffrey M. Stolwijk, Kranti A. Mapuskar, Amanda L. Kalen, Garry R. Buettner, Joseph J. Cullen, Douglas R. Spitz, John Michael Buatti, Bryan G. Allen · 2021 · International Journal of Molecular Sciences
Vitamin C (Ascorbate) and Redox Topics in Cancer
Christophe Glorieux, Pedro Buc Calderón · 2021 · Antioxidants and Redox Signaling
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Ye‐Jin Jung, Naotaka Noda, Junichiro Takaya, Masahiro Abo, Kohei Toh, Ken Tajiri, Changyi Cui, Lu Zhou, Shin‐ichi Sato, Motonari Uesugi · 2022 · ACS Chemical Biology
Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells
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Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression
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Błażej Rubiś, Michał W. Łuczak, Casey Krawic, Anatoly Zhitkovich · 2019 · Free Radical Biology and Medicine
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Diego Pozzer, Roberto William Invernizzi, Bert Blaauw, Orazio Cantoni, Ester Zito · 2019 · Antioxidants and Redox Signaling
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Marta Schirripa, Stacey A. Cohen, Francesca Battaglin, Heinz‐Josef Lenz · 2017 · Seminars in Oncology
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Ayaka Ito, Haruka Nasako, Risa Akizuki, Yui Takashina, Hiroaki Eguchi, Toshiyuki Matsunaga, Yuta Yoshino, Satoshi Endo, Akira Ikari · 2021 · International Journal of Molecular Sciences
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Jingjing Wan, Juan Zhou, Lu Fu, Yubin Li, Hua‐Wu Zeng, Xi‐Ke Xu, Chao Lv, Hui‐Zi Jin · 2021 · Frontiers in Pharmacology
Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo–/– mice
Gabi U. Dachs, Elizabeth J. Campbell, Margreet C.M. Vissers · 2016 · Hypoxia
Intravenous Vitamin C attenuates hemorrhagic shock-related renal injury through the induction of SIRT1 in rats
Mengzhi Qi, Yi Yao, Rongli Xie, Silei Sun, Wenwu Sun, Jinlong Wang, Ying Chen, Bing Zhao, Erzhen Chen, Enqiang Mao · 2018 · Biochemical and Biophysical Research Communications
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Barry B. Halliwell · 2018 · Free Radical Research
Effect of ascorbic acid on morphology of post-thawed human adipose-derived stem cells
Komang Ardi Wahyuningsih, Karina Karina, Imam Rosadi, Iis Rosliana, Wismo Reja Subroto · 2020 · Stem Cell Investigation
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Redox Balance in Cancer in the Context of Tumor Prevention and Treatment
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High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression
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High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells
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Hilal Ahmad Mir, Roshia Ali, Zahoor Ahmad Wani, Firdous Ahmad Khanday · 2022 · International Journal of Biological Macromolecules
Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms
Santosh Pandit, Mokkapati VRSS, Saga Helgadóttir, Fredrik Westerlund, Ivan Mijakovic̀ · 2017 · Clinical Microbiology Open Access
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Lu Gong, Xiao Pan, Chuan-Bian Lim, Anna de Polo, John B. Little, Zhi-Min Yuan · 2018 · Oncogene
Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells
Mitsuyo Tsuma-Kaneko, Masakazu Sawanobori, Shohei Kawakami, Tomoko Uno, Yoshihiko Nakamura, Makoto Onizuka, Kiyoshi Ando, Hiroshi Kawada · 2018 · Scientific Reports
Hepatomas are exquisitely sensitive to pharmacologic ascorbate (P-AscH-)
Xuan Zhang, Tiefu Liu, Zehuan Li, Feng Yanling, Christopher Peter Corpe, Shanshan Liu, Jingpu Zhang, Xiaomeng He, Feng Liu, Xu Li et al. · 2019 · Theranostics
Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells
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Proteins moonlighting in tumor metabolism and epigenetics
Lei Lv, Qun‐Ying Lei · 2021 · Frontiers of Medicine
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Rong Yang, Fangqing Deng, Yingchun Yang, Qing Chao Tian, Shuaiqi Huangfu, Luqiu Yang, Jing Hou, Guanghao Yang, Wei Pang, Jueru Lu et al. · 2023 · Biomaterials
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis
Montana T. Morris, Abhishek Jain, Boshi Sun, Vadim Kurbatov, Engjel Muca, Zhaoshi Zeng, Ying Jin, Jatin Roper, Jun Lü, Philip B. Paty et al. · 2023 · Cancer Letters
Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity
Yool Lee · 2023 · Cancers
GAPDH with NAD+-binding site mutation competitively inhibits the wild-type and affects glucose metabolism in cancer
Rani Kunjithapatham, Shanmugasundaram Ganapathy‐Kanniappan · 2018 · Biochimica et Biophysica Acta (BBA) - General Subjects
Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming
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Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro
Francisca Espinoza, Rocío Magdalena, Natalia Saldivia, Nery Jara, Fernando Martínez, Luciano Ferrada, Katterine Salazar, Felipe Ávila, Francisco Nualart · 2020 · Antioxidants
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Vitamin C Inhibits Blood-Stage Plasmodium Parasites via Oxidative Stress
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HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
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Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids
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The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia
Serena Travaglini, Carmelo Gurnari, Silvia Antonelli, Giorgia Silvestrini, Nélida I. Noguera, Tiziana Ottone, Maria Teresa Voso · 2022 · Frontiers in Cell and Developmental Biology
High-Dose Ascorbate in Combination with Anti-PD1 Checkpoint Inhibition as Treatment Option for Malignant Melanoma
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Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints
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Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells
Y. Robert Li · 2016 · Reactive Oxygen Species
Pancreatic adenocarcinoma protein-protein interaction network analysis.
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A Systems Biology Study in Tomato Fruit Reveals Correlations between the Ascorbate Pool and Genes Involved in Ribosome Biogenesis, Translation, and the Heat-Shock Response
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Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry
Nnenna Elebo, J. Omoshoro–Jones, Pascaline Fonteh-Fru, John WS Devar, Christiaan De Wet van Zyl, Barend Christiaan Vorster, Martin Smith, Stefano Cacciatore, Luiz Fernando Zerbini, Geoffrey Patrick Candy et al. · 2021 · Metabolites
L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide
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