Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Yun, Jihye, Mullarky, Edouard, Lu, Changyuan, Bosch, Kaitlyn N., Kavalier, Adam, Rivera, Keith, Roper, Jatin, Chio, Iok In Christine, Giannopoulou, Eugenia G., Rago, Carlo, Muley, Ashlesha, Asara, John M., Paik, Jihye, Elemento, Olivier, Chen, Zhengming, Pappin, Darryl J., Dow, Lukas E., Papadopoulos, Nickolas, Gross, Steven S., Cantley, Lewis C.·2015·Science

DOI 10.1126/science.aaa5004

Cited by (915)

Items 201–300 of 915

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Xia, Jiliang, Xu, Hongwei, Zhang, Xiaoyan, Allamargot, Chantal, Coleman, Kristen L., Nessler, Randy, Frech, Ivana, Tricot, Guido, Zhan, Fenghuang · 2017 · EBioMedicine
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KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression
Chi Zhang, Runfeng Yu, Senmao Li, Ming Yuan, Tuo Hu, Jiaqi Liu, Haoxian Ke, Shubiao Ye, Jihye Yun, Junfeng Huang et al. · 2025 · Cell Death and Differentiation
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Yu‐Ling Chang, Maura Maria Rossetti, Hera C. Vlamakis, David Casero, Gemalene M. Sunga, Nicholas Harre, Shelley A. Miller, Romney M. Humphries, Thaddeus S. Stappenbeck, Kenneth William Simpson et al. · 2018 · Mucosal Immunology
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Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells
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Feng Wang, Ming-Ming He, Jian Xiao, Yanqiao Zhang, Xianglin Yuan, Weijia Jia Fang, Yan Zhang, Wei Wang, Xiao-Hua Hu, Zhigang Ma et al. · 2022 · Clinical Cancer Research
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Daria Capece, Daniela Verzella, Barbara Di Francesco, Edoardo Alesse, Guido Franzoso, Francesca Zazzeroni · 2019 · Seminars in Cell and Developmental Biology
An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
Pedro González‐Menéndez, Manuela Romano, Hongxia Yan, Ruhi S. Deshmukh, Julien Papoin, Leal Oburoglu, Marie Daumur, Anne‐Sophie Dumé, Ira Phadke, Cédric Mongellaz et al. · 2021 · Cell Reports
The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
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Xinkui Liu, Jiarui Wu, Dan Zhang, Kaihuan Wang, Xiaojiao Duan, Xiaomeng Zhang · 2018 · Evidence-based Complementary and Alternative Medicine
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Feng Wang, Ming-Ming He, Zixian Wang, Li Su, Ying Jin, Chao Ren, Si‐Mei Shi, Bingtian Bi, Shuang-Zhen Chen, Zhi-Da Lv et al. · 2019 · BMC Cancer
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Mason, Joshua A., Cockfield, Jordan A., Pape, Daniel J., Meissner, Hannah, Sokolowski, Michael T., White, Taylor C., Valentín López, José C., Liu, Juan, Liu, Xiaojing, Martínez-Reyes, Inmaculada et al. · 2021 · Cell Reports
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Yuanling Tang, Dandan Li, Jia-Yu Duan, Leiming Sheng, Xin Wang · 2023 · World Journal of Gastroenterology
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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response
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Guangzhe Ge, Peng Ding, Ziying Xu, Bao Guan, Zijuan Xin, Qun He, Yuanyuan Zhou, Xuesong Li, Liqun Zhou, Weimin Ci · 2018 · EMBO Reports
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Joshi, Molishree, Kim, Jihye, D’Alessandro, Angelo, Monk, Emily, Bruce, Kimberley, Elajaili, Hanan, Nozik-Grayck, Eva, Goodspeed, Andrew, Costello, James C., Schlaepfer, Isabel R. · 2020 · Cancers
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Phillip M. Kemp Bohan, Gautam Mankaney, Timothy J. Vreeland, Robert Connor Chick, Diane F. Hale, Jessica L. Cindass, Annelies T. Hickerson, Daniel C. Ensley, Vance Y. Sohn, Guy Travis Clifton et al. · 2020 · Familial Cancer
High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro
Nélida I. Noguera, Elvira Pelosi, Daniela Francesca Angelini, Maria Liliana Piredda, Gisella Guerrera, Eleonora Piras, Luca Battistini, Lauretta Massai, Anna Concetta Berardi, Gianfranco Catalano et al. · 2017 · Oncotarget
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
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Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge
Christina Wohlrab, Elisabeth Phillips, Gabi U. Dachs · 2017 · Frontiers in Oncology
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Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells
Jordan A. Cockfield, Zachary T. Schafer · 2019 · Cancers
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