The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Reversible centriole depletion with an inhibitor of Polo-like kinase 4
Open accessAbstract
Giving an old organelle the old heave-ho: Centrioles are ancient cellular organelles that build centrosomes, the major microtubule-organizing centers in animal cells. Duplication of centrioles is tightly controlled to ensure that each dividing cell has precisely two centrosomes. Human cancer cells often have extra centrosomes, which has been hypothesized to confer a proliferative advantage. Wong et al. developed small molecules (centrinones) that allowed them to reversibly “delete” centrioles from cells (see the Perspective by Stearns). Surprisingly, cancer cells continued to divide in the absence of centrosomes, whereas normal cells stopped dividing. Science , this issue p. 1155 ; see also p. 1091
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Cited by
Targeting Mitosis in Cancer: Emerging Strategies
Dominguez-Brauer, C., Thu, K. L., Mason, J. M., Blaser, H., Bray, M. R., & Mak, T. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.006 · Cited by 495
(2025) · doi:10.1038/s44318-025-00564-4 · Cited by 2
Metadata
- Authors
- Wong, Y. L., Anzola, J. V., Davis, R. L., Yoon, M., Motamedi, A., Kroll, A., Seo, C. P., Hsia, J. E., Kim, S. K., Mitchell, J. W., Mitchell, B. J., Desai, A., Gahman, T. C., Shiau, A. K., & Oegema, K.
- Venue
- Science
- Published
- 2015-06-05
- Volume
- 348
- Issue
- 6239
- Pages
- 1155-1160
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072460025
- Cited by
- 473
- References
- 64
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wong, Y. L., Anzola, J. V., Davis, R. L., Yoon, M., Motamedi, A., Kroll, A., Seo, C. P., Hsia, J. E., Kim, S. K., Mitchell, J. W., Mitchell, B. J., Desai, A., Gahman, T. C., Shiau, A. K., & Oegema, K. (2015). Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. https://doi.org/10.1126/science.aaa5111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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