Targeting Mitosis in Cancer: Emerging Strategies

Gene expression profiling predicts clinical outcome of breast cancer

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Microtubules as a target for anticancer drugs

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Cell cycle, CDKs and cancer: a changing paradigm

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

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The spindle-assembly checkpoint in space and time

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Paclitaxel (Taxol)

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A mechanism linking extra centrosomes to chromosomal instability

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

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Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

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Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

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Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

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Cell cycle kinases as therapeutic targets for cancer

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Molecular Diagnosis of Burkitt's Lymphoma

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Mitotic catastrophe: a mechanism for avoiding genomic instability

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The Polo kinase Plk4 functions in centriole duplication

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The Spindle Assembly Checkpoint

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

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SAK/PLK4 Is Required for Centriole Duplication and Flagella Development

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Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

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The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

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Centrosome Amplification Can Initiate Tumorigenesis in Flies

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Does aneuploidy cause cancer?

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Targeted anti-mitotic therapies: can we improve on tubulin agents?

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Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

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Reversible centriole depletion with an inhibitor of Polo-like kinase 4

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Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

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Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

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Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

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The proliferation rate paradox in antimitotic chemotherapy

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Identification of Aneuploidy-Selective Antiproliferation Compounds

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Genome-wide survey of protein kinases required for cell cycle progression

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Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

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Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

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Lack of PTEN sequesters CHK1 and initiates genetic instability

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Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

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Mitosis-targeted anti-cancer therapies: where they stand

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The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage

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Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

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Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study

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Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

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Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

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The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions

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Development of Cell-Cycle Inhibitors for Cancer Therapy

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Aurora kinase inhibitors: Progress towards the clinic

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

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Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

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Mitotic regulation by NIMA-related kinases

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Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

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Physiological Relevance of Cell Cycle Kinases

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

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Greatwall maintains mitosis through regulation of PP2A

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A dual role for Bub1 in the spindle checkpoint and chromosome congression

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Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

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Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

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Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

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The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells

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A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

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Nek9 is a Plk1‐activated kinase that controls early centrosome separation through Nek6/7 and Eg5

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The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

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Overexpression of the mitotic checkpoint genes BUB1, BUBR1 , and BUB3 in gastric cancer—association with tumour cell proliferation

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High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells

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Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.

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Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery

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The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cyclePreprint

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A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast

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Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation

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Extra centrosomes and/or chromosomes prolong mitosis in human cells

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Functional Viability Profiles of Breast Cancer

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NEK2A Interacts with MAD1 and Possibly Functions as a Novel Integrator of the Spindle Checkpoint Signaling

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The Role of CDK4/6 Inhibition in Breast Cancer

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Mammalian G1 cyclins and cell cycle progression.

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Reduced expression of PTEN correlates with breast cancer progression

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Nek family of kinases in cell cycle, checkpoint control and cancer

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Highlights of the Latest Advances in Research on CDK Inhibitors

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