The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
BMP gradients: A paradigm for morphogen-mediated developmental patterning
Open accessAbstract
BMP mophogens direct growth and fate: As shown in classic fate-mapping studies, tissues and organs arise from specific regions of the embryo. Work over the past few decades has identified molecular players directing this choreographed development. Bone morphogenetic proteins (BMPs) and their antagonists establish domains in developing embryos. Bier and De Robertis review historical events for key discoveries in this area. They go on to lay out the current understanding of how diffusible morphogens form gradients to subdivide germ layers into distinct territories and organize body axes, regulate growth, and maintain stem cell niches. Science , this issue 10.1126/science.aaa5838
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
A theory of biological pattern formation
Gierer, A., & Meinhardt, H. (1972) · Kybernetik · doi:10.1007/bf00289234 · Cited by 3,158
Positional information and the spatial pattern of cellular differentiation
Wolpert, L. (1969) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(69)80016-0 · Cited by 3,050
The structure of evolutionary theory
(2002) · Choice Reviews Online · doi:10.5860/choice.39-6411 · Cited by 2,756
GALTON, F. (1907) · Nature · doi:10.1038/075450a0 · Cited by 1,080
CRICK, F. (1970) · Nature · doi:10.1038/225420a0 · Cited by 907
Direct and Long-Range Action of a DPP Morphogen Gradient
Nellen, D., Burke, R., Struhl, G., & Basler, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81114-9 · Cited by 892
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
The Structure of Evolutionary Theory
Gould, S. J. (2002) · Harvard University Press eBooks · doi:10.4159/9780674417922 · Cited by 636
Ramírez-Weber, F.-A., & Kornberg, T. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80771-0 · Cited by 612
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Chang, H.-M., Qiao, J., & Leung, P. C. K. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw039 · Cited by 265
Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112
BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids
Duval, N., Vaslin, C., Barata, T. C., Frarma, Y., Contremoulins, V., Baudin, X., Nedelec, S., & Ribes, V. C. (2019) · Development · doi:10.1242/dev.175430 · Cited by 93
Koenecke, N., Johnston, J., Gaertner, B., Natarajan, M., & Zeitlinger, J. (2016) · Genome Biology · doi:10.1186/s13059-016-1057-2 · Cited by 65
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Akhurst, R. J., & Padgett, R. W. (2015) · Science Signaling · doi:10.1126/scisignal.aad0416 · Cited by 52
Metadata
- Authors
- Bier, E., & De Robertis, E. M.
- Venue
- Science
- Published
- 2015-06-26
- Volume
- 348
- Issue
- 6242
- Pages
- aaa5838-aaa5838
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1435682058
- Cited by
- 311
- References
- 112
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- green
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