Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells

Sefik, Esen, Geva-Zatorsky, Naama, Oh, Sungwhan, Konnikova, Liza, Zemmour, David, McGuire, Abigail Manson, Burzyn, Dalia, Ortiz-Lopez, Adriana +9 more·2015·Science
DOI 10.1126/science.aaa9420

Cited by (879)

Items 801–879 of 879

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  5. Gut Microbiome and the Immune System
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  28. Additional file 2 of Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation
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  29. Additional file 3 of Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation
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  76. A tolerogenic function for gut TFH cells
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