Sestrin2 is a leucine sensor for the mTORC1 pathway

Wolfson, Rachel L., Chantranupong, Lynne, Saxton, Robert A., Shen, Kuang, Scaria, Sonia M., Cantor, Jason R., Sabatini, David M.·2016·Science

Cited by (1,000)

Items 601–700 of 1,000

  1. Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling
    Xuejin Wang, Weifeng Liu, Deyi Zhuang, Shaoxian Hong, Jingfang Chen · 2017 · Oncotarget
  2. Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunctionassociated steatotic liver disease
    Eiji Kakazu, Masaaki Mino, Tatsuya Kanto · 2025 · Clinical and Molecular Hepatology
  3. Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions inlongissimus dorsimuscle of weanling piglets
    Qiwen Fan, Baisheng Long, Guokai Yan, Zhichang Wang, Min Yan Shi, Xiaoyu Bao, Jun Hu, Xiuzhi Li, Changqing Chen, Zilong Zheng et al. · 2017 · British Journal Of Nutrition
  4. ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice
    H. Kouzu, Y. Tatekoshi, Hsiang-Chun Chang, J. Shapiro, Warren A. McGee, Adam De Jesus, I. Ben-Sahra, Z. Arany, J. Leor, Chun-Lei Chen et al. · 2022 · Journal of Clinical Investigation
  5. Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific
    William O. Jonsson, Emily T. Mirek, Ronald C. Wek, Tracy Gautsch Anthony · 2022 · The FASEB Journal
  6. Empagliflozin ameliorates diabetic cardiomyopathy via regulated branched-chain amino acid metabolism and mTOR/p-ULK1 signaling pathway-mediated autophagy
    Lin Zhang, Heming Zhang, Xiuzhu Xie, Ruping Tie, Xiaolin Shang, Qianqian Zhao, Junjie Xu, Liyuan Jin, Jinying Zhang, Ping Ye · 2023 · Diabetology & Metabolic Syndrome
  7. Dietary approaches for exploiting metabolic vulnerabilities in cancer
    Otília Menyhárt, Balázs Győrffy · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  8. PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway
    Yimin Fu, Lei Tao, Xiaojun Wang, Binyou Wang, Weilin Qin, Lei Song · 2024 · Experimental Gerontology
  9. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma
    Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe, Tomomi Aida, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo et al. · 2018 · Scientific Reports
  10. The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders
    Yu‐Tzu Shih, Yi‐Ping Hsueh · 2018 · Journal of Biomedical Science
  11. Actionable Metabolic Pathways in Heart Failure and Cancer—Lessons From Cancer Cell Metabolism
    Anja Karlstaedt, Walter B. Schiffer, Heinrich Taegtmeyer · 2018 · Frontiers in Cardiovascular Medicine
  12. A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
    Junsheng Qu, Moyi Luo, Jingwen Zhang, Fang Han, Ningning Hou, Ruiyan Pan, Xiaodong Sun · 2021 · Cancer Cell International
  13. NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling
    Hasegawa, Yuto, Zhu, Xiaolei, Kamiya, Atsushi · 2019 · Journal of Clinical Investigation
  14. Advances in the regulatory mechanisms of mTOR in necroptosis
    Yawen Xie, Guoyu Zhao, Xianli Lei, Na Cui, Hao Wang · 2023 · Frontiers in Immunology
  15. p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3
    Alexander Haidurov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, George Sergeevich Krasnov, Anna V. Kudryavtseva, Andrei V. Budanov · 2025 · Cell Communication and Signaling
  16. Effects of rumen-protected leucine on production performance and starch digestion in the small intestine of lactating goats
    Jie Chen, Xin Jian Lei, Lei Wang, Yuan Ling Zhang, Dangdang Wang, Li Chao Zhao, Tao Liu, Yun Tian Yang, Jun Yao · 2022 · Animal Feed Science and Technology
  17. Improved Satellite Cell Proliferation Induced by L-Carnosine Benefits Muscle Growth of Pigs in Part through Activation of the Akt/mTOR/S6K Signaling Pathway
    Yaojun Liu, Wenqiang Shen, Tao Liu, R. Mosenthin, Yinghui Bao, Peng Chen, Wenbo Hao, Lihong Zhao, Jianyun Zhang, Cheng Ji et al. · 2022 · Agriculture
  18. Covalent JNK Inhibitor, JNK-IN-8, Suppresses Tumor Growth in Triple-Negative Breast Cancer by Activating TFEB- and TFE3-Mediated Lysosome Biogenesis and Autophagy
    Milad Soleimani, Alexander J. Somma, Tamer Saad Kaoud, Ria Goyal, Jorge Bustamante, Dennis Wylie, Nisha Holay, Agnieszka P. Looney, Uma P. Giri, Todd Triplett et al. · 2022 · Molecular Cancer Therapeutics
  19. The Ragulator complex: delving its multifunctional impact on metabolism and beyond
    Kohei Tsujimoto, Hyota Takamatsu, Atsushi Kumanogoh · 2023 · Inflammation and Regeneration
  20. The resolution of phagosomes
    Sivakami Mylvaganam, Spencer A. Freeman · 2023 · Immunological Reviews
  21. p62 bodies: cytosolic zoning by phase separation
    Reo Kurusu, Hideaki Morishita, Masaaki Komatsu · 2023 · The Journal of Biochemistry
  22. Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases
    MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao · 2023 · Journal of Molecular and Cellular Cardiology
  23. Double-Edge Effects of Leucine on Cancer Cells
    Burkitkan Akbay, Zhannur Omarova, А. Н. Трофимов, Bayan Sailike, Orynbassar Karapina, Ferdinand Molnár, Tursonjan Tokay · 2024 · Biomolecules
  24. Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function
    Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama et al. · 2017 · The Journal of Immunology
  25. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
    Shusaku Shibutani, Hana Okazaki, Hiroyuki Iwata · 2017 · Journal of Biological Chemistry
  26. Sestrin 2 controls the cardiovascular aging process via an integrated network of signaling pathways
    Yunxia Liu, Xiaoyu Du, Zhehao Huang, Yang Zheng, Nanhu Quan · 2020 · Ageing Research Reviews
  27. Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3
    Yanhong Wang, JunQiang Liu, Hui Chen Wu, Xingtang Fang, Hong Chen, Chunlei Zhang · 2016 · European Journal of Nutrition
  28. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer
    Ling Tian, Congcong Chen, Yanguan Guo, Fan Zhang, Jinye Mi, Qi Feng, Shengbin Lin, Naite Xi, Jiaxin Tian, Li Yu et al. · 2021 · Neoplasia
  29. mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss
    Maurizio Cortada, Soledad Levano, Daniel Bodmer · 2021 · International Journal of Molecular Sciences
  30. The effects of glucagon and the target of rapamycin (TOR) on skeletal muscle protein synthesis and age-dependent sarcopenia in humans
    María M. Adeva‐Andany, Carlos Fernández‐Fernández, Yosua López-Pereiro, Isabel Calvo‐Castro, Natalia Carneiro-Freire · 2021 · Clinical Nutrition ESPEN
  31. Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
    Xiaobo Yang, Hengbing Zu, Yongfei Zhao, Kai Yao · 2022 · Frontiers in Aging Neuroscience
  32. Targeting mTOR in the Context of Diet and Whole-body Metabolism
    Nikos Koundouros, John Blenis · 2022 · Endocrinology
  33. Sestrin2 as a Protective Shield against Cardiovascular Disease
    Muhammad Zahid, Shahenda Salah Abdelsalam, Hicham Raïq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni · 2023 · International Journal of Molecular Sciences
  34. Combined metabolomic and lipidomic analysis uncovers metabolic profile and biomarkers for papillary thyroid carcinoma
    Zipeng Wang, Yiqin Yang, Yurong Xing, Dandan Si, Suhua Wang, Jiashuo Lin, Cai Li, Ji Zhang, Detao Yin · 2023 · Scientific Reports
  35. Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae.
    Qing-Zhong Zeng, Yasuhiro Araki, Takeshi Noda · 2023 · Cell Reports
  36. L-arginine alleviates heat stress-induced mammary gland injury through modulating CASTOR1-mTORC1 axis mediated mitochondrial homeostasis
    Zhongchao Gai, Hu Songhao, Yujiao He, Sijia Yan, Ranran Wang, Guoli Gong, Jieqiong Zhao · 2024 · The Science of The Total Environment
  37. Reconsidering the pre-eminence of dietary leucine and plasma leucinemia for predicting the stimulation of postprandial muscle protein synthesis rates
    Alistair J. Monteyne, Sam West, Francis B. Stephens, Benjamin Toby Wall · 2024 · American Journal of Clinical Nutrition
  38. A potential strategy for counteracting age-related sarcopenia: preliminary evidence of combined exercise training and leucine supplementation
    Zhi Xia, Jason M. Cholewa, Y. Zhao, Yi Yang, H. Shang, H. Jiang, Qi Su, Nelo Eidy Zanchi · 2017 · Food & Function
  39. FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition
    Céline Barthelemy, Abdoulaye Oury Barry, Laure Twyffels, Bruno André · 2017 · Scientific Reports
  40. Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
    Ignacio Navas‐Enamorado, Michel Bernier, Gloria Brea‐Calvo, Rafael de Cabo · 2017 · Ageing Research Reviews
  41. Sestrins are Gatekeepers in the Way from Stress to Aging and Disease
    Alexandra A. Dalina, Irina E. Kovaleva, Andrei V. Budanov · 2018 · Molecular Biology
  42. Autophagy and cancer metabolism—The two‐way interplay
    Ruei-Liang Yan, Ruey‐Hwa Chen · 2021 · IUBMB Life
  43. A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
    Na Li, Beilei Hua, Qing Chen, Fukang Teng, Meiyu Ruan, Mengnan Zhu, Li Zhang, Yinbo Huo, Hongqin Liu, Min Zhuang et al. · 2022 · Cell Reports
  44. Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling
    Sun-Yee Kim, Qunxiang Ong, Yilie Liao, Zhaobing Ding, Alicia Qian Ler Tan, Ler Ting Rachel Lim, Hui Min Tan, Siew Lay Lim, Qian Yi Lee, Weiping Han · 2023 · International Journal of Molecular Sciences
  45. Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells
    Chaochao Luo, Nan Zheng, Shengguo Zhao, Jiaqi Wang · 2019 · Journal of Agricultural and Food Chemistry
  46. Constitutive activation of mTORC1 signaling induced by biallelic loss-of-function mutations in SZT2 underlies a discernible neurodevelopmental disease
    Yuji Nakamura, Kohji Kato, Naomi Tsuchida, Naomichi Matsumoto, Yoshiyuki Takahashi, Shinji Saitoh · 2019 · PLoS ONE
  47. Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans
    Sabih Rashid, Kim B. Pho, Hiva Mesbahi, Lesley T. MacNeil · 2020 · BioEssays
  48. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis
    Zeba Mueed, Devanshu Mehta, Pankaj Kumar Rai, Mohammad Amjad Kamal, Nitesh Kumar Poddar · 2020 · Current Pharmaceutical Design
  49. Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation.
    L. F. Piochi, Ivo F. Machado, C. Palmeira, A. Rolo · 2021 · Ageing Research Reviews
  50. The regulatory mechanism of amino acids on milk protein and fat synthesis in mammary epithelial cells: a mini review
    Meihong Han, Minghui Zhang · 2021 · Animal Biotechnology
  51. Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer
    Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhong-xue Fu · 2022 · Cancer Cell International
  52. Emerging role of branched chain amino acids in metabolic disorders: A mechanistic review
    R. A, N. Agrawal, H. Kumar, Vipin Kumar · 2018 · PharmaNutrition
  53. Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search
    Havers, Tim, Held, Steffen, Schönfelder, Martin, Geisler, Stephan, Wackerhage, Henning · 2025 · Sports Medicine
  54. Accumulation of branched-chain amino acids deteriorates the neuroinflammatory response of Müller cells in diabetic retinopathy via leucine/Sestrin2-mediated sensing of mTOR signaling
    Qiaoyun Gong, Jingyi Wang, Dawei Luo, Yupeng Xu, Rulin Zhang, Xin Li, Zihan Yin, Junwei Fang, Hai-Yan Wang · 2024 · Acta Diabetologica
  55. Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury
    Samaneh DiMartino, Monica Patricia Revelo, Sandeep K. Mallipattu, Siân E. Piret · 2024 · American Journal of Physiology-Renal Physiology
  56. Recent advances in amino acid sensing and new challenges for protein nutrition in aquaculture
    Cheng-Dong Liu, Xuan Wang, Hui-Hui Zhou, K. Mai, G. He · 2019 · Marine Life Science & Technology
  57. Medical Aspects of mTOR Inhibition in Kidney Transplantation
    Elena Cuadrado‐Payán, Fritz Diekmann, David Cucchiari · 2022 · International Journal of Molecular Sciences
  58. Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC
    Meiting Xue, Jiawei Xiao, Wenna Jiang, Yanhui Wang, Duo Zuo, Haohua An, Li Ren · 2023 · Translational Oncology
  59. Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24-h Skeletal Muscle Protein Synthesis in Healthy, Middle-Aged Women
    Emily J. Arentson‐Lantz, Zachary Von Ruff, Gavin Connolly, Frank R. Albano, Sean Paul Kilroe, Adam Wacher, Wayne W. Campbell, Douglas Paddon‐Jones · 2024 · Journal of Nutrition
  60. E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis
    Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lü · 2024 · Advanced Science
  61. Energy metabolism profile of the effects of amino acid treatment on skeletal muscle cells: Leucine inhibits glycolysis of myotubes
    Reiko Suzuki, Yoriko Sato, Kodwo Amuzuah Obeng, Daisuke Suzuki, Yusuke Komiya, Shin-ichi Adachi, Fumiaki Yoshizawa, Yusuke Sato · 2020 · Nutrition
  62. Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation
    Marcel Seibert, Nina Kurrle, Frank Schnütgen, Hubert L. Serve · 2021 · Matrix Biology
  63. Leucine retention in lysosomes is regulated by starvation
    Urmi Bandyopadhyay, P. Todorova, N. Pavlova, Y. Tada, C. Thompson, Lydia W. S. Finley, Michael Overholtzer · 2022 · Proceedings of the National Academy of Sciences of the United States of America
  64. Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor
    Sameer Ullah Khan, Anup Singh Pathania, Abubakar Wani, Kaneez Fatima, Mubashir Javeed Mintoo, Baseerat Hamza, Masroor Ahmad Paddar, Bhumika Wadhwa, Loveleena Kour Anand, Mir Shahid Maqbool et al. · 2022 · Scientific Reports
  65. The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1
    Veronika Mlitz, Gaëlle Gendronneau, Irina Berlin, Maria Buchberger, Leopold Eckhart, Erwin Tschachler · 2016 · PLoS ONE
  66. Late evening snacks with branched-chain amino acids improve the Fischer ratio with patients liver cirrhosis at fasting in the next morning
    Hiroki Maki, Hisami Yamanaka‐Okumura, Takafumi Katayama, Yuka Ozawa, Akihito Hosoda, Naomi Kurata, Fumitake Amemiya · 2019 · Clinical Nutrition ESPEN
  67. Amino Acids as Regulators of Cell Metabolism
    Semen V. Nesterov, Lev S. Yaguzhinsky, Podoprigora Gi, Yaroslav R. Nartsissov · 2020 · Biochemistry (Moscow)
  68. Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights
    Md. Takdir Hossain, Md. Arafat Hossain · 2025 · Drug development research (Print)
  69. Branched-chain amino acids in muscle growth: mechanisms, physiological functions, and applications
    Shuyong Xu, Guangyong Zhao, M. Hanigan, G. Cantalapiedra-Hijar, Mengmeng Li · 2025 · Journal of Animal Science and Biotechnology
  70. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling
    Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan Eickhoff et al. · 2022 · Journal of Biological Chemistry
  71. Identification of Epigenetically Regulated Genes Distinguishing Intracranial from Extracranial Melanoma Metastases
    Dana Westphal, Matthias Meinhardt, Konrad Grützmann, Lisa Schöne, Julian Steininger, Lena T. Neuhaus, Miriam Wiegel, Daniel Schrimpf, Daniela Ellen Aust, Evelin Schröck et al. · 2023 · Journal of Investigative Dermatology
  72. Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
    Xue Zhao, Shinichi Sakamoto, Jiaxing Wei, Sangjon Pae, Shinpei Saito, Tomokazu Sazuka, Yusuke Imamura, Naohiko Anzai, Tomohiko Ichikawa · 2023 · International Journal of Molecular Sciences
  73. Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
    Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai · 2023 · Cancer Cell International
  74. E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and implications for immunotherapies
    Maoyu Wang, Zhensheng Zhang, Zhizhou Li, Yasheng Zhu, Chuanliang Xu · 2023 · Frontiers in Immunology
  75. Effects of Resistance Exercise and Essential Amino Acid Intake on Muscle Quality, Myokine, and Inflammation Factors in Young Adult Males
    Deok-Hwa Jeong, Kyu-Min Park, Jinseok Lee, Jiye Choi, Haifeng Du, Hyeongmo Jeong, Liangliang Li, Kenji Sakai, Sunghwun Kang · 2024 · Nutrients
  76. Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms
    Fumiaki Obata, Masayuki Miura · 2024 · Annual Review of Genetics
  77. Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive
    Ido Livneh, Bertrand Fabre, Gilad Goldhirsh, Lulu Chen, Adar Zinger, Yael Shammai Vainer, Maya Kaduri, Aviva Dahan, Tamar Ziv, Avi Schroeder et al. · 2024 · Cell Death and Differentiation
  78. The de novo synthesis of GABA and its gene regulatory function control hepatocellular carcinoma metastasis
    Li Li, Youli Kang, Running Cheng, Fangming Liu, Fujia Wu, Zizhao Liu, Junjie Kou, Zhenxi Zhang, Jian Li, Haitao Zhao et al. · 2024 · Developmental Cell
  79. MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability
    Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani et al. · 2017 · Molecular Cancer
  80. Nutritional Support to Counteract Muscle Atrophy
    Daniel J. Owens · 2018 · Advances in experimental medicine and biology
  81. Leucine regulates α-amylase and trypsin synthesis in dairy calf pancreatic tissue in vitro via the mammalian target of rapamycin signalling pathway
    Long J Guo, Jun Hu Yao, Chen Zheng, H.B. Tian, Yandan Liu, S. M. Liu, Chuanjiang Cai, X. R. Xu, Yangchun Cao · 2019 · animal
  82. Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism.
    Sai Harisha Rajanala, Rachel Ringquist, Vincent L. Cryns · 2019 · PubMed Central
  83. Experimental Approaches in Delineating mTOR Signaling
    Jiayi Qian, Siyuan Su, Pengda Liu · 2020 · Genes
  84. Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans
    Joel T. Steyer, Damien J. Downes, Cameron C. Hunter, Pierre Migeon, Richard B. Todd · 2021 · mBio
  85. SEA and GATOR 10 Years Later
    Yahir A Loissell-Baltazar, Svetlana Dokudovskaya · 2021 · Cells
  86. Emerging roles of microRNAs in the metabolic control of immune cells
    Qiuming Yao, Zhenyu Song, Bin Wang, Jin‐an Zhang · 2018 · Cancer Letters
  87. NRF3 activates mTORC1 arginine-dependently for cancer cell viability
    Hirose, Shuuhei, Waku, Tsuyoshi, Tani, Misato, Masuda, Haruka, Endo, Keiko, Ashitani, Sanae, Aketa, Iori, Kitano, Hina, Nakada, Sota, Wada, Ayaka et al. · 2023 · iScience
  88. Knockdown of SESN2 Exacerbates Cerebral Ischemia–Reperfusion Injury Through Enhancing Glycolysis via the mTOR / HIF ‐1α Pathway
    Zhi‐Hui Wang, Yingao Huang, Yonggang Zhang, Hua Zhu, Mohammad Rohul Amin, Ran Chen, Lijuan Gu, Xiaoxing Xiong · 2025 · CNS Neuroscience & Therapeutics
  89. mTORC1 senses glutamine and other amino acids through GCN2
    Gianluca Figlia, Sandra Müller, Fabiola Garcia Cortizo, Marilena Neff, Glynis Klinke, Gernot Poschet, Aurelio A. Teleman · 2025 · The EMBO Journal
  90. Alterations in protein and amino acid metabolism in honeybees (Apis mellifera) fed different l-leucine diets during the larval stage
    Lanting Ma, Ying Wang, Weixing Zhang, Hongfang Wang, Zhenguo Liu, Baohua Xu · 2016 · Journal of Asia-Pacific Entomology
  91. The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination
    Xing Huang, Xingyuan Xu, Xun Wang, Tianyu Tang, Enliang Li, Xiaozhen Zhang, Jian Xu, Hang Shen, Chengxiang Guo, Tao Xu et al. · 2020 · Signal Transduction and Targeted Therapy
  92. Co-ingestion of glutamine and leucine synergistically promotes mTORC1 activation
    Ryoji Yoshimura, Shuichi Nomura · 2022 · Scientific Reports
  93. Cестрины – шлагбаумы на путях от стресса к старению и болезням
    Alexandra A. Dalina, Irina E. Kovaleva, Andrei V. Budanov · 2018 · Molecular Biology
  94. Putative roles of SLC7A5 (LAT1) transporter in pain
    Sascha R.A. Alles, Kimberly Gómez, Aubin Moutal, Rajesh Khanna · 2020 · Neurobiology of Pain
  95. Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators
    Yulong Tang, Simeng Liao, Guang Liu, Xia Xiong, Hongnan Liu, Fengna Li, Zhiliang Tan, Xiangfeng Kong, Yulong Yin, Bie Tan · 2021 · Cell Biology and Toxicology
  96. Dampened Muscle mTORC1 Response Following Ingestion of High-Quality Plant-Based Protein and Insect Protein Compared to Whey
    Gommaar D’Hulst, Evi Masschelein, Katrien De Bock · 2021 · Nutrients
  97. Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1
    Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Thanh Minh Nguyen, Xiaogang Wu, Fahad Munir, Muhammad Babar Jamshed, Qiyu Zhang · 2021 · Computers in Biology and Medicine
  98. Rodent diet aids and the fallacy of caloric restriction
    Alexander Martin Wolf · 2021 · Mechanisms of Ageing and Development
  99. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
    Dawid Krokowski, Raul Jobava, Krzysztof J. Szkop, Chien-Wen Chen, Fu Xu, Sarah Venus, Bo‐Jhih Guan, Jing Wu, Zhaofeng Gao, Wioleta Banaszuk et al. · 2022 · Cell Reports
  100. CASTORing New Light on Amino Acid Sensing
    James E Hughes Hallett, Brendan D. Manning · 2016 · Cell