Sestrin2 is a leucine sensor for the mTORC1 pathway

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2. The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer
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3. Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease
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4. Regulation of metabolic health by essential dietary amino acids
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5. Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells
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6. Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway
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7. Amino acid transporters as emerging therapeutic targets in cancer
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8. Structure of the nutrient-sensing hub GATOR2
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9. <scp>GATOR</scp>opathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations
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10. Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes
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11. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy.
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12. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
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14. Immunomodulatory role of branched-chain amino acids
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15. Plant target of rapamycin signaling network: Complexes, conservations, and specificities
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16. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
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17. The functions and roles of sestrins in regulating human diseases
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18. mTORC1 senses stresses: Coupling stress to proteostasis
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19. A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
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20. Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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21. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
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22. Sestrin Regulation of TORC1: Is Sestrin a Leucine Sensor?
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23. Aminoacyl-tRNA synthetases and amino acid signaling
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24. mTOR in programmed cell death and its therapeutic implications.
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25. mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics
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26. VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
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27. Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism*
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28. Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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29. Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases
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30. Multistability in Macrophage Activation Pathways and Metabolic Implications
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31. Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling
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32. Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis
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33. Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart
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34. Evidence for a Role for Sestrin1 in Mediating Leucine‐Induced Activation of mTORC1 in Skeletal Muscle
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35. The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids
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36. The Architecture of the Rag GTPase Signaling Network
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37. Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
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38. Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
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39. Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
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40. Structural basis for the assembly of the Ragulator-Rag GTPase complex
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41. Regulation and function of the SLC38A3/SNAT3 glutamine transporter
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42. Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity
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43. PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
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44. Translation in amino-acid-poor environments is limited by tRNAGln charging
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45. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
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46. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagosome Induction and the Metabolic Transition of Activated T Cells
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47. Coping with Protein Quality Control Failure
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48. GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids
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49. “Nutraceuticals” in relation to human skeletal muscle and exercise
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50. Impact of gut microbiota on gut‐distal autoimmunity: a focus on T cells
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51. Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
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52. Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy
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54. Discovery of NV-5138, the first selective Brain mTORC1 activator
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55. Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury
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56. Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism
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57. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy
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58. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
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59. Dietary restriction of amino acids for Cancer therapy
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60. Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases
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61. The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency.
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62. Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer
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63. The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients
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64. Nutrient sensors and their crosstalk
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65. Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men
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66. A systems perspective on placental amino acid transport
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67. Leucine and Mammalian Target of Rapamycin–Dependent Activation of Muscle Protein Synthesis in Aging
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68. The role of mTOR in age-related diseases
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69. Functional and pathologic association of aminoacyl-tRNA synthetases with cancer
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70. Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
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71. Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control
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72. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress
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74. Deep contrastive learning enables genome-wide virtual screening
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75. Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases
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76. Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression
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77. Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine
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78. Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent
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79. Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia
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80. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.
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81. A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states
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82. Regulation of Muscle Growth in Early Postnatal Life in a Swine Model
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83. Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
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84. The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond
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85. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
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86. mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth
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87. Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells
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88. Sestrin2 is involved in the Nrf2-regulated antioxidative signaling pathway in luteolin-induced prevention of the diabetic rat heart from ischemia/reperfusion injury
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90. Autophagy and cancer cell metabolism
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91. Sestrins in Physiological Stress Responses
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92. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
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93. Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances
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94. Importance of Energy, Dietary Protein Sources, and Amino Acid Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life
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95. Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia
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97. The complex network of mTOR signalling in the heart
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98. Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage
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99. Gestational Leucylation Suppresses Embryonic T‐Box Transcription Factor 5 Signal and Causes Congenital Heart Disease
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100. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function
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