Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
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Abstract
BACKGROUND: Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the livers of young and old long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omics approach. RESULTS: We found that NMR livers display a unique expression pattern of mitochondrial proteins that results in distinct metabolic features of their mitochondria. For instance, we observed a generally reduced respiration rate associated with lower protein levels of respiratory chain components, particularly complex I, and increased capacity to utilize fatty acids. Interestingly, we show that the same molecular networks are affected during aging in both NMRs and humans, supporting a direct link to the extraordinary longevity of both species. Finally, we identified a novel detoxification pathway linked to longevity and validated it experimentally in the nematode Caenorhabditis elegans. CONCLUSIONS: Our work demonstrates the benefits of integrating proteomic and transcriptomic data to perform cross-species comparisons of longevity-associated networks. Using a multispecies approach, we show at the molecular level that livers of NMRs display progressive age-dependent changes that recapitulate typical signatures of aging despite the negligible senescence and extraordinary longevity of these rodents.
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947 · see citing works
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855 · see citing works
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · cited 1× · see citing works
“For each animal, we obtained a quantitative proteome profile by liquid chromatography tandem mass spectrometry and estimated absolute protein abundances using the iBAQ method [28].”
MethodREVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264 · see citing works
A Direct Approach to False Discovery Rates
Storey, J. D. (2002) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00346 · Cited by 5,603 · see citing works
Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, J. V., & Mann, M. (2011) · Journal of Proteome Research · doi:10.1021/pr101065j · Cited by 5,349 · see citing works
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
Vogel, C., & Marcotte, E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3185 · Cited by 4,195 · see citing works
Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
2016 update of the PRIDE database and its related tools
Vizcaíno, J. A., Csordás, A., del‐Toro, N., Dianes, J. A., Griss, J., Lavidas, I., Mayer, G., Pérez‐Riverol, Y., Reisinger, F., Ternent, T., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1145 · Cited by 3,466 · see citing works
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356 · see citing works
Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440 · see citing works
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works
GAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333 · see citing works
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
Bruderer, R., Bernhardt, O. M., Gandhi, T., Miladinović, S. M., Cheng, L.-Y., Messner, S., Ehrenberger, T., Zanotelli, V., Butscheid, Y., Escher, C., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.044305 · Cited by 1,238 · see citing works
Ultrasensitive proteome analysis using paramagnetic bead technology
Hughes, C. S., Föehr, S., Garfield, D. A., Furlong, E. E. M., Steinmetz, L. M., & Krijgsveld, J. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145625 · Cited by 1,194 · see citing works
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works
Malhotra, D., Portales-Casamar, É., Singh, A., Srivastava, S., Arenillas, D. J., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq212 · Cited by 796 · see citing works
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Tian, X., Azpurua, J., Hine, C., Vaidya, A. M., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V. A., & Seluanov, A. (2013) · Nature · doi:10.1038/nature12234 · Cited by 786 · see citing works
Human Ageing Genomic Resources: new and updated databases
Tacutu, R., Thornton, D., Johnson, E., Budovsky, A., Barardo, D., Craig, T., Diana, E., Lehmann, G., Toren, D., Wang, J., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1042 · Cited by 738 · see citing works
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737 · see citing works
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646 · see citing works
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Park, T. J., Reznick, J., Peterson, B. L., Blass, G., Omerbašić, D., Bennett, N. C., Kuich, P. H. J. L., Zasada, C., Browe, B. M., Hamann, W., et al. (2017) · Science · doi:10.1126/science.aab3896 · Cited by 641 · see citing works
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., et al. (2011) · Nature · doi:10.1038/nature10533 · Cited by 576 · see citing works
C. elegans dauer formation and the molecular basis of plasticityPreprint
Fielenbach, N., & Antebi, A. (2008) · Genes & Development · doi:10.1101/gad.1701508 · Cited by 556 · see citing works
St-Onge, M.-P., & Gallagher, D. (2010) · Nutrition · doi:10.1016/j.nut.2009.07.004 · Cited by 494 · see citing works
Buffenstein, R. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-007-0237-5 · Cited by 487 · see citing works
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.027 · Cited by 451 · see citing works
The Metabolism of Fossorial Rodents: A Study of Convergence
McNab, B. K. (1966) · Ecology · doi:10.2307/1934259 · Cited by 428 · see citing works
Pérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418 · see citing works
Accurate and Sensitive Peptide Identification with Mascot Percolator
Brosch, M., Yu, L., Hubbard, T., & Choudhary, J. S. (2009) · Journal of Proteome Research · doi:10.1021/pr800982s · Cited by 414 · see citing works
Gatto, L., & Lilley, K. S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr645 · Cited by 389 · see citing works
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.024 · Cited by 372 · see citing works
Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
Biteau, B., Karpac, J., Supoyo, S., DeGennaro, M., Lehmann, R., & Jasper, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001159 · Cited by 351 · see citing works
High oxidative damage levels in the longest‐living rodent, the naked mole‐rat
Andziak, B., O’Connor, T. P., Qi, W., deWaal, E., Pierce, A. P., Chaudhuri, A. R., Remmen, H. V., & Buffenstein, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00237.x · Cited by 351 · see citing works
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
Lewis, K. N., Wason, E., Edrey, Y. H., Kristan, D. M., Nevo, E., & Buffenstein, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417566112 · Cited by 248 · see citing works
Gene expression drives local adaptation in humans
Fraser, H. B. (2013) · Genome Research · doi:10.1101/gr.152710.112 · Cited by 247 · see citing works
Hahn, O., Grönke, S., Stubbs, T. M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M. J. O., Beyer, A., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1187-1 · Cited by 236 · see citing works
Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response
Kim, H.-E., Grant, A. R., Simic, M., Kohnz, R. A., Nomura, D. K., Durieux, J., Riera, C. E., Sanchez, M., Kapernick, E. A., Wolff, S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.027 · Cited by 227 · see citing works
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice
Miwa, S., Jow, H., Baty, K., Johnson, A. J., Czapiewski, R., Saretzki, G. C., Treumann, A., & von Zglinicki, T. (2014) · Nature Communications · doi:10.1038/ncomms4837 · Cited by 207 · see citing works
Ori, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., Ingolia, N. T., Hetzer, M. W., & Beck, M. (2015) · Cell Systems · doi:10.1016/j.cels.2015.08.012 · Cited by 201 · see citing works
Self-citationAdaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes
Fang, X., Seim, I., Huang, Z., Gerashchenko, M. V., Xiong, Z., Turanov, A. A., Zhu, Y., Lobanov, A. V., Fan, D., Yim, S. H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.030 · Cited by 197 · see citing works
DNA repair in species with extreme lifespan differences
MacRae, S. L., Croken, M. M., Calder, R. B., Aliper, A. M., Milholland, B., White, R. R., Zhavoronkov, A. A., Gladyshev, V. N., Seluanov, A., Gorbunova, V. A., et al. (2015) · Aging · doi:10.18632/aging.100866 · Cited by 196 · see citing works
Lipid metabolism in the elderly
Toth, M., & Tchernof, A. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601033 · Cited by 187 · see citing works
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila
Brandt, T., Mourier, A., Tain, L. S., Partridge, L., Larsson, N., & Kühlbrandt, W. (2017) · eLife · doi:10.7554/elife.24662 · Cited by 176 · see citing works
Cho, S., Kim, J., Lee, J. H., Sim, J. H., Cho, D.-H., Bae, I., Lee, H., Seol, M. A., Shin, H. M., Kim, T.-J., et al. (2017) · Scientific Reports · doi:10.1038/srep41667 · Cited by 164 · see citing works
Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins
Hanzén, S., Vielfort, K., Yang, J., Roger, F., Andersson, V., Zamarbide-Forés, S., Andersson, R., Malm, L., Palais, G., Biteau, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.006 · Cited by 161 · see citing works
Extreme hypoxia tolerance of naked mole-rat brain
Larson, J., & Park, T. J. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32833370cf · Cited by 159 · see citing works
Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old
Safdar, A., DeBeer, J., & Tarnopolsky, M. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.010 · Cited by 158 · see citing works
The Naked Mole Rat--A New Record for the Oldest Living Rodent
Buffenstein, R., & Jarvis, J. U. M. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.21.pe7 · Cited by 158 · see citing works
Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.01.014 · Cited by 147 · see citing works
Self-citationGene expression defines natural changes in mammalian lifespan
Fushan, A. A., Turanov, A. A., Lee, S., Kim, E. B., Lobanov, A. V., Yim, S. H., Buffenstein, R., Lee, S., Chang, K., Rhee, H., et al. (2015) · Aging Cell · doi:10.1111/acel.12283 · Cited by 140 · see citing works
Being cool: how body temperature influences ageing and longevity
Keil, G., Cummings, E., & de Magalhães, J. P. (2015) · Biogerontology · doi:10.1007/s10522-015-9571-2 · Cited by 135 · see citing works
The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It
Lewis, K. N., Andziak, B., Yang, T., & Buffenstein, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4911 · Cited by 119 · see citing works
Neoteny, Prolongation of Youth: From Naked Mole Rats to “Naked Apes” (Humans)
Skulachev, V. P., Holtze, S., Vyssokikh, M. Y., Bakeeva, L. E., Skulachev, M. V., Markov, A. V., Hildebrandt, T. B., & Садовничий, В. А. (2017) · Physiological Reviews · doi:10.1152/physrev.00040.2015 · Cited by 114 · see citing works
Self-citationComprehensive transcriptional landscape of aging mouse liver
White, R. R., Milholland, B., MacRae, S. L., Lin, M., Zheng, D., & Vijg, J. (2015) · BMC Genomics · doi:10.1186/s12864-015-2061-8 · Cited by 113 · see citing works
Hughes, C. S., McConechy, M. K., Cochrane, D. R., Nazeran, T. M., Karnezis, A. N., Huntsman, D. D., & Morin, G. B. (2016) · Scientific Reports · doi:10.1038/srep34949 · Cited by 110 · see citing works
Rodriguez, K. A., Edrey, Y. H., Osmulski, P. A., Gaczynska, M. E., & Buffenstein, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035890 · Cited by 102 · see citing works
Stress Resistance in the Naked Mole-Rat: The Bare Essentials – A Mini-Review
Lewis, K. N., Mele, J., Hornsby, P. J., & Buffenstein, R. (2012) · Gerontology · doi:10.1159/000335966 · Cited by 100 · see citing works
Exercise-induced Nrf2-signaling is impaired in aging
Done, A. J., Gage, M. J., Nieto, N. C., & Traustadóttir, T. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.024 · Cited by 99 · see citing works
Yu, C., Li, Y., Holmes, A., Szafranski, K., Faulkes, C. G., Coen, C. W., Buffenstein, R., Platzer, M., de Magalhães, J. P., & Church, G. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026729 · Cited by 99 · see citing works
Self-citationPeroxiredoxins, gerontogenes linking aging to genome instability and cancerPreprint
Nyström, T., Yang, J., & Molin, M. (2012) · Genes & Development · doi:10.1101/gad.200006.112 · Cited by 92 · see citing works
Zhao, Y., Tyshkovskiy, A., Muñoz‐Espín, D., Tian, X., Serrano, M., de Magalhães, J. P., Nevo, E., Gladyshev, V. N., Seluanov, A., & Gorbunova, V. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721160115 · Cited by 92 · see citing works
The microenvironment of naked mole‐rat burrows in East Africa
Holtze, S., Braude, S. H., Lemma, A., Koch, R., Morhart, M., Szafranski, K., Platzer, M., Alemayehu, F., Göritz, F., & Hildebrandt, T. B. (2017) · African Journal of Ecology · doi:10.1111/aje.12448 · Cited by 90 · see citing works
Self-citationSgarbi, G., Matarrese, P., Pinti, M., Lanzarini, C., Ascione, B., Gibellini, L., Dika, E., Patrizi, A., Tommasino, C., Capri, M., et al. (2014) · Aging · doi:10.18632/aging.100654 · Cited by 90 · see citing works
Sexual activity and reproduction delay ageing in a mammal
Dammann, P., & Burda, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.012 · Cited by 89 · see citing works
Extending healthy ageing: nutrient sensitive pathway and centenarian population
Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-9 · Cited by 83 · see citing works
Dammann, P., Šumbera, R., Maßmann, C., Scherag, A., & Burda, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018757 · Cited by 79 · see citing works
Buczak, K., Ori, A., Kirkpatrick, J. M., Hölzer, K., Dauch, D., Roessler, S. K., Endris, V., Lasitschka, F., Parca, L., Schmidt, A., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000189 · Cited by 79 · see citing works
Self-citationLoss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis
Beaudry, V. G., Jiang, D., Dusek, R. L., Park, E. J., Knezevich, S. R., Ridd, K., Vogel, H. S., Bastian, B. C., & Attardi, L. D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001168 · Cited by 78 · see citing works
Keane, M. P., Craig, T., Alföldi, J., Berlin, A. M., Johnson, J., Seluanov, A., Gorbunova, V. A., Palma, F. D., Lindblad‐Toh, K., Church, G. M., et al. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu579 · Cited by 77 · see citing works
Luis, N. M., Wang, L., Ortega, M., Deng, H., Katewa, S. D., Li, P. W.-L., Karpac, J., Jasper, H., & Kapahi, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.003 · Cited by 65 · see citing works
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
Sahm, A., Bens, M., Szafranski, K., Holtze, S., Groth, M., Görlach, M., Calkhoven, C. F., Müller, C., Schwab, M. G., Kraus, J. M., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007272 · Cited by 62 · see citing works
Self-citationPosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes
Sahm, A., Bens, M., Platzer, M., & Szafranski, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx179 · Cited by 57 · see citing works
Self-citationWhat have we learned on aging from omics studies?
Cellerino, A., & Ori, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.06.012 · Cited by 56 · see citing works
Self-citationBuffenstein, R., & Yahav, S. (1991) · British Journal Of Nutrition · doi:10.1079/bjn19910084 · Cited by 55 · see citing works
The Functions of PPARs in Aging and Longevity
Erol, A. (2007) · PPAR Research · doi:10.1155/2007/39654 · Cited by 54 · see citing works
Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling
Delire, B., Lebrun, V., Selvais, C., Henriet, P., Bertrand, A., Horsmans, Y., & Leclercq, I. A. (2016) · Aging · doi:10.18632/aging.101124 · Cited by 53 · see citing works
Schmidt, H., Malik, A., Bicker, A., Poetzsch, G., Avivi, A., Shams, I., & Hankeln, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-13905-z · Cited by 51 · see citing works
Good Ol’ Fat: Links between Lipid Signaling and Longevity
Bustos, V., & Partridge, L. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.07.001 · Cited by 45 · see citing works
Effects of aging on basal fat oxidation in obese humans
Solomon, T. P. J., Marchetti, C. M., Krishnan, R. K., González, F., & Kirwan, J. P. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.021 · Cited by 44 · see citing works
A Novel Sulfotransferase Abundantly Expressed in the Dauer Larvae of Caenorhabditis elegans
Hattori, K., Inoue, M., Inoue, T., Arai, H., & Tamura, H.-O. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj041 · Cited by 35 · see citing works
Bens, M., Szafranski, K., Holtze, S., Sahm, A., Groth, M., Kestler, H. A., Hildebrandt, T. B., & Platzer, M. (2018) · BMC Biology · doi:10.1186/s12915-018-0546-z · Cited by 34 · see citing works
Self-citationParallel evolution of genes controlling mitonuclear balance in short-lived annual fishes
Sahm, A., Bens, M., Platzer, M., & Cellerino, A. (2017) · Aging Cell · doi:10.1111/acel.12577 · Cited by 33 · see citing works
Self-citationFRAMA: from RNA-seq data to annotated mRNA assemblies
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Self-citationHoltze, S., Eldarov, C. M., Vays, V. B., Vangeli, I. M., Vysokikh, M. Y., Bakeeva, L. E., Skulachev, V. P., & Hildebrandt, T. B. (2016) · Biochemistry (Moscow) · doi:10.1134/s000629791612004x · Cited by 19 · see citing works
Self-citationBeltrán‐Sánchez, H., & Finch, C. E. (2018) · eLife · doi:10.7554/elife.34427 · Cited by 8 · see citing works
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Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Kelmer Sacramento, E., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209596 · Cited by 236 · see citing works
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Self-citationSchüler, S. C., Kirkpatrick, J. M., Schmidt, M., Santinha, D., Koch, P., Di Sanzo, S., Cirri, E., Hemberg, M., Ori, A., & von Maltzahn, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109223 · Cited by 106 · see citing works
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Horvath, S., Haghani, A., Macoretta, N., Ablaeva, J., Zoller, J. A., Li, C. Z., Zhang, J., Takasugi, M., Zhao, Y., Rydkina, E. B., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00152-1 · Cited by 110 · see citing works
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Swovick, K., Firsanov, D., Welle, K. A., Hryhorenko, J. R., Wise, J. P., George, C., Sformo, T. L., Seluanov, A., Gorbunova, V., & Ghaemmaghami, S. (2021) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002301 · Cited by 73 · see citing works
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Bens, M., Szafranski, K., Holtze, S., Sahm, A., Groth, M., Kestler, H. A., Hildebrandt, T. B., & Platzer, M. (2018) · BMC Biology · doi:10.1186/s12915-018-0546-z · Cited by 34 · see citing works
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Sanzo, S. D., Spengler, K., Leheis, A., Kirkpatrick, J. M., Rändler, T. L., Baldensperger, T., Dau, T., Henning, C., Parca, L., Marx, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26982-6 · Cited by 30 · see citing works
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Mota‐Martorell, N., Jové, M., Berdún, R., & Pamplona, R. (2021) · Communications Biology · doi:10.1038/s42003-021-02254-3 · Cited by 14 · see citing works
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Zhao, Y., Wang, Y., Chen, L., Chen, H., Tang, Y., He, Y., & Yao, P. (2025) · Nutrients · doi:10.3390/nu17101618 · Cited by 10 · see citing works
Heiby, J. C., & Ori, A. (2022) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2022.100416 · Cited by 11 · see citing works
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Carmeli-Ligati, S., Shipov, A., Dumont, M., Holtze, S., Hildebrandt, T. B., & Shahar, R. (2019) · Bone · doi:10.1016/j.bone.2019.115035 · Cited by 10 · see citing works
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Morevati, M., Mace, M. L., Egstrand, S., Nordholm, A., Doğanlı, C., Strand, J., Rukov, J. L., Torsetnes, S. B., Gorbunova, V. A., Ølgaard, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94972-1 · Cited by 6 · see citing works
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Poetzsch, G., Jelacic, L., Dammer, L., Hellmann, S. L., Balling, M., Andrade-Navarro, M. A., Avivi, A., Shams, I., Bicker, A., & Hankeln, T. (2025) · npj Aging · doi:10.1038/s41514-025-00206-3 · Cited by 4 · see citing works
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Pergande, M. R., Amoroso, V. G., Nguyen, T. T. A., Li, W., Vice, E. N., Park, T. J., & Cologna, S. M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00131 · Cited by 4 · see citing works
Mazzetto, M., Reichwald, K., Koch, P., Groth, M., & Cellerino, A. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae255 · Cited by 3 · see citing works
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Massaar, S., & Sanders, M. A. (2023) · Aging and Cancer · doi:10.1002/aac2.12061 · Cited by 3 · see citing works
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Di Fraia, D., Anitei, M., Mackmull, M.-T., Parca, L., Behrendt, L., Andres-Pons, A., Gilmour, D., Helmer Citterich, M., Kaether, C., Beck, M., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201397 · Cited by 2 · see citing works
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Sanzo, S. D., Spengler, K., Leheis, A., Kirkpatrick, J. M., Rändler, T. L., Baldensperger, T., Parca, L., Marx, C., Wang, Z., Glomb, M. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.16.342311 · Cited by 2 · see citing works
Self-citationMazzetto, M., Reichwald, K., Sacramento, E. K., Koch, P., Ori, A., Groth, M., & Cellerino, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.20.567823 · Cited by 2 · see citing works
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Patel, T. T., Amoroso, V. G., Hardell, K. N. L., Narayan, V., Delaney, M. A., & Buffenstein, R. (2026) · Mammalian Biology · doi:10.1007/s42991-025-00549-0 · Cited by 1 · see citing works
Hypoxia Promotes Gluconeogenesis Through PGC‐1α in the Liver of Lasiopodomys brandtii
Li, M., Huang, M., Wan, J., Gao, Y., Song, J., Li, X., Li, Q., Cheng, H., Shao, T., & Wang, Z. (2025) · Integrative Zoology · doi:10.1111/1749-4877.12961 · Cited by 1 · see citing works
Non-programmed (Nonadaptive) Aging Theories
Vanhaelen, Q. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_50-1 · Cited by 1 · see citing works
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Marino, A., Fraia, D. D., Panfilova, D., Sahu, A. K., & Ori, A. (2023) · bioRxiv · doi:10.1101/2023.12.02.569713 · Cited by 2 · see citing works
Self-citationSociality shapes mitochondrial adaptations supporting hypoxia tolerancePreprint
Rossi, A., Ruwolt, M., Kakouri, P., Kosten, T., Kunz, S., Puchkov, D., Reznick, J., Purfürst, B., Omerbašić, D., Mendez-Aranda, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615914 · Cited by 1 · see citing works
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Vanhaelen, Q. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_50
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- Authors
- Heinze, I., Bens, M., Calzia, E., Holtze, S., Dakhovnik, O., Sahm, A., Kirkpatrick, J. M., Szafranski, K., Romanov, N., Sama, S. N., Holzer, K., Singer, S., Ermolaeva, M., Platzer, M., Hildebrandt, T., & Ori, A.
- Affiliations
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- Universität Ulm (DE)
- Leibniz Institute for Zoo and Wildlife Research (DE)
- European Molecular Biology Laboratory (DE)
- Universitätsmedizin Greifswald (DE)
- Corresponding author
- Platzer, Matthias
- Hildebrandt, Thomas
- ORCID
- Venue
- BMC Biology
- Published
- 2018-08-02
- Volume
- 16
- Issue
- 1
- Pages
- 82-82
- ISSN
- 1741-7007 (ISSN-L)
- PMC
- PMC6090990
- OpenAlex
- W2884076930
- Cited by
- 65
- References
- 93
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 7 · 2018: 1
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (DE) (PL 173/8-1, GRK1715)
- Leibniz-Gemeinschaft (SAW-2012-FLI-2)
- Deutsche Forschungsgemeinschaft (SFB/TR209 (Project B04))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- naked mole-rat, longevity, aging, liver proteome, mitochondrial proteins, mitochondrial respiration, respiratory chain complex I, fatty acid utilization, detoxification pathways, cross-species comparison, guinea pig, Caenorhabditis elegans, senescence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Guinea Pigs, Humans, Liver, Longevity, Male, Middle Aged, Species Specificity, Caenorhabditis elegans, Mole Rats, Proteome
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