Cited by 65Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

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Heinze, Ivonne, Bens, Martin, Calzia, Enrico, Holtze, Susanne, Dakhovnik, Oleksandr, Sahm, Arne, Kirkpatrick, Joanna M., Szafranski, Karol +8 more·2018·BMC Biology

Published version of a preprint

Abstract

BACKGROUND: Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the livers of young and old long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omics approach. RESULTS: We found that NMR livers display a unique expression pattern of mitochondrial proteins that results in distinct metabolic features of their mitochondria. For instance, we observed a generally reduced respiration rate associated with lower protein levels of respiratory chain components, particularly complex I, and increased capacity to utilize fatty acids. Interestingly, we show that the same molecular networks are affected during aging in both NMRs and humans, supporting a direct link to the extraordinary longevity of both species. Finally, we identified a novel detoxification pathway linked to longevity and validated it experimentally in the nematode Caenorhabditis elegans. CONCLUSIONS: Our work demonstrates the benefits of integrating proteomic and transcriptomic data to perform cross-species comparisons of longevity-associated networks. Using a multispecies approach, we show at the molecular level that livers of NMRs display progressive age-dependent changes that recapitulate typical signatures of aging despite the negligible senescence and extraordinary longevity of these rodents.

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Authors
Heinze, I., Bens, M., Calzia, E., Holtze, S., Dakhovnik, O., Sahm, A., Kirkpatrick, J. M., Szafranski, K., Romanov, N., Sama, S. N., Holzer, K., Singer, S., Ermolaeva, M., Platzer, M., Hildebrandt, T., & Ori, A.
Affiliations
  • Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
  • Universität Ulm (DE)
  • Leibniz Institute for Zoo and Wildlife Research (DE)
  • European Molecular Biology Laboratory (DE)
  • Universitätsmedizin Greifswald (DE)
Corresponding author
  • Platzer, Matthias
  • Hildebrandt, Thomas
Venue
BMC Biology
Published
2018-08-02
Volume
16
Issue
1
Pages
82-82
ISSN
1741-7007 (ISSN-L)
OpenAlex
W2884076930
Cited by
65
References
93
Citations by year
2026: 1 · 2025: 9 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 7 · 2018: 1
FWCI
3.24
Type
journal article
Language
en
Open access
Locations
  • BMC Biology (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft (DE) (PL 173/8-1, GRK1715)
  • Leibniz-Gemeinschaft (SAW-2012-FLI-2)
  • Deutsche Forschungsgemeinschaft (SFB/TR209 (Project B04))
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
naked mole-rat, longevity, aging, liver proteome, mitochondrial proteins, mitochondrial respiration, respiratory chain complex I, fatty acid utilization, detoxification pathways, cross-species comparison, guinea pig, Caenorhabditis elegans, senescence
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Animals, Guinea Pigs, Humans, Liver, Longevity, Male, Middle Aged, Species Specificity, Caenorhabditis elegans, Mole Rats, Proteome

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