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Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
Abstract
Chemical modification of RNA for function: Chemical modifications play an important role in modifying and regulating the function of DNA and RNA. Delatte et al. show that, in the fruit fly, many messenger RNAs (mRNAs) contain the modified base 5-hydroxymethylcytosine (5hmC). The chemical mark is added by the same enzyme that adds 5hmC to DNA. Because many mRNAs involved in neuronal development contain 5hmC, blocking the enzyme causes brain defects and is lethal. In vivo, RNA hydroxymethylation promotes mRNA translation. Science , this issue p. 282
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“Other studies also reported RNA m5C oxidation by TET2 or Drosophila TET homologue17–20.”
From RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis (2024) · cites this paper as [17]
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“…antibodies (e.g., against N1-methyladenosine [Dominissini et al., 2016], N6-methyladenosine [Dominissini et al., 2012], and 5-hydroxymethylcytosine [Delatte et al., 2016]) or chemical reactivity of the modification (for pseudouridine [Carlile et al., 2014; Schwartz et al., 2014], m5C [Schaefer,…”
BackgroundThe mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
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Metadata
- Authors
- Delatte, B., Wang, F., Ngoc, L. V., Collignon, E., Bonvin, E., Deplus, R., Calonne, E., Hassabi, B., Putmans, P., Awe, S., Wetzel, C., Kreher, J., Soin, R., Creppe, C., Limbach, P. A., Gueydan, C., Kruys, V., Brehm, A., Minakhina, S., Defrance, M., Steward, R., & Fuks, F.
- Venue
- Science
- Published
- 2016-01-15
- Volume
- 351
- Issue
- 6270
- Pages
- 282-285
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 411
- References
- 6
- Language
- en
- Funders
- Belgian Fonds de la Recherche Scientifique (FNRS)
- Belgian American Educational Foundation (BAEF)
- WBHealth (CanDx)
- Action de Recherche Concertee (ARC) (AUWB-2010-2015 ULB-No 7)
- Belgian Fondation contre le Cancer
- Fonds Gaston Ithier
- NIH (RO1 GM089992)
- ARC (AV.12/17)
- Brachet and Van Buuren Funds
- National Science Foundation (NSF CHE 1212625, 1507357)
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- Delatte, B., Wang, F., Ngoc, L. V., Collignon, E., Bonvin, E., Deplus, R., Calonne, E., Hassabi, B., Putmans, P., Awe, S., Wetzel, C., Kreher, J., Soin, R., Creppe, C., Limbach, P. A., Gueydan, C., Kruys, V., Brehm, A., Minakhina, S., . . . Fuks, F. (2016). Transcriptome-wide distribution and function of RNA hydroxymethylcytosine. Science. https://doi.org/10.1126/science.aac5253
