The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
Abstract
Chemical modification of RNA for function: Chemical modifications play an important role in modifying and regulating the function of DNA and RNA. Delatte et al. show that, in the fruit fly, many messenger RNAs (mRNAs) contain the modified base 5-hydroxymethylcytosine (5hmC). The chemical mark is added by the same enzyme that adds 5hmC to DNA. Because many mRNAs involved in neuronal development contain 5hmC, blocking the enzyme causes brain defects and is lethal. In vivo, RNA hydroxymethylation promotes mRNA translation. Science , this issue p. 282
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“Other studies also reported RNA m5C oxidation by TET2 or Drosophila TET homologue17–20.”
From RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis (2024) · cites this paper as [17]
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Cited by
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949
DNA methylation on N6-adenine in mammalian embryonic stem cells
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METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation
Pandolfini, L., Barbieri, I., Bannister, A. J., Hendrick, A., Andrews, B., Webster, N., Murat, P., Mach, P., Brandi, R., Robson, S. C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.040 · Cited by 491
“…antibodies (e.g., against N1-methyladenosine [Dominissini et al., 2016], N6-methyladenosine [Dominissini et al., 2012], and 5-hydroxymethylcytosine [Delatte et al., 2016]) or chemical reactivity of the modification (for pseudouridine [Carlile et al., 2014; Schwartz et al., 2014], m5C [Schaefer,…”
BackgroundThe mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., Chang, H. Y., & Barna, M. (2017) · Cell · doi:10.1016/j.cell.2017.05.022 · Cited by 439
The m6A epitranscriptome: transcriptome plasticity in brain development and function
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330
Wang, Y., Zhang, S., Jia, W., Fan, P., Wang, L., Li, X., Chen, J., Cao, Z., Du, X., Liu, Y., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01169-2 · Cited by 143
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
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Synthetic modified messenger RNA for therapeutic applications
Gao, M., Zhang, Q., Feng, X.-H., & Liu, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.020 · Cited by 89
Role of RNA modifications in brain and behavior
Jung, Y., & Goldman, D. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12444 · Cited by 66
“hm(5)C tends to be found in polyribosomes and is associated with increased translation efficiency in Drosophila.(26)”
BackgroundTET dioxygenases localize at splicing speckles and promote RNA splicing
Hastert, F. D., Weber, J., Bauer, C., Zhadan, A., Singh, D. N. D., Dix, T. C., Arnold, R., Bessonov, S., Soller, M., Leonhardt, H., et al. (2025) · Nucleus · doi:10.1080/19491034.2025.2536902 · Cited by 5
“Interestingly, TET has been shown to interact with microRNAs regulating hm5C in the adult brain [40], and hm5C was found in the RNA of Drosophila S2 cells [41].”
Influential
Metadata
- Authors
- Delatte, B., Wang, F., Ngoc, L. V., Collignon, E., Bonvin, E., Deplus, R., Calonne, E., Hassabi, B., Putmans, P., Awe, S., Wetzel, C., Kreher, J., Soin, R., Creppe, C., Limbach, P. A., Gueydan, C., Kruys, V., Brehm, A., Minakhina, S., Defrance, M., Steward, R., & Fuks, F.
- Venue
- Science
- Published
- 2016-01-15
- Volume
- 351
- Issue
- 6270
- Pages
- 282-285
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 411
- References
- 6
- Language
- en
- Funders
- Belgian Fonds de la Recherche Scientifique (FNRS)
- Belgian American Educational Foundation (BAEF)
- WBHealth (CanDx)
- Action de Recherche Concertee (ARC) (AUWB-2010-2015 ULB-No 7)
- Belgian Fondation contre le Cancer
- Fonds Gaston Ithier
- NIH (RO1 GM089992)
- ARC (AV.12/17)
- Brachet and Van Buuren Funds
- National Science Foundation (NSF CHE 1212625, 1507357)
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