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RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Open accessAbstract
RNA editing helps identify cellular RNAs: Adenosine bases in messenger RNA (mRNAs) can be enzymatically modified and changed into inosine bases. This RNA “editing” is mediated by adenosine deaminase acting on RNA (ADAR) enzymes. Liddicoat et al. show that the in vivo targets of the principal editing enzyme, ADAR1, are long double-stranded RNA (dsRNA) structures in noncoding portions of cellular mRNAs. ADAR1-directed editing of these cellular targets is critical to avoid activation of an immune response to dsRNA in the cytoplasm, because dsRNA is also a marker of viral infection. Science , this issue p. 1115
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Non-coding RNA networks in cancer
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DAMP-sensing receptors in sterile inflammation and inflammatory diseases
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A-to-I editing of coding and non-coding RNAs by ADARs
Nishikura, K. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.4 · Cited by 1,041
Gene regulation in the immune system by long noncoding RNAs
Chen, Y. G., Satpathy, A. T., & Chang, H. Y. (2017) · Nature Immunology · doi:10.1038/ni.3771 · Cited by 697
A-to-I RNA editing — immune protector and transcriptome diversifier
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Metadata
- Authors
- Liddicoat, B. J., Piskol, R., Chalk, A. M., Ramaswami, G., Higuchi, M., Hartner, J. C., Li, J. B., Seeburg, P. H., & Walkley, C. R.
- Venue
- Science
- Published
- 2015-09-04
- Volume
- 349
- Issue
- 6252
- Pages
- 1115-1120
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2156891661
- Cited by
- 955
- References
- 6
- FWCI
- 22.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Liddicoat, B. J., Piskol, R., Chalk, A. M., Ramaswami, G., Higuchi, M., Hartner, J. C., Li, J. B., Seeburg, P. H., & Walkley, C. R. (2015). RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science. https://doi.org/10.1126/science.aac7049
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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