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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Open accessAbstract
An Aluring new autoantibody target: Autoimmunity is the immune system's ultimate act of betrayal. Cells designed to protect against invading microbes suddenly target the host instead. In the autoimmune disease systemic lupus erythematosus, antibodies target DNA and host proteins, including the RNA binding protein Ro60. Hung et al. discovered that Ro60 bound to endogenous Alu retroelements. They detected antibody-Ro60-Alu RNA immune complexes in the blood of individuals with lupus and an enrichment of Alu transcripts. Ro60 bound to Alu probably primes RNA-binding innate immune receptors within B cells, leading these cells to make antibodies that target Ro60-Alu RNA and drive disease-causing inflammation. Science , this issue p. 455
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Cites
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1838 · Cited by 1,126
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Gene regulation in the immune system by long noncoding RNAs
Chen, Y. G., Satpathy, A. T., & Chang, H. Y. (2017) · Nature Immunology · doi:10.1038/ni.3771 · Cited by 697
Roles for retrotransposon insertions in human disease
Hancks, D. C., & Kazazian, H. H. (2016) · Mobile DNA · doi:10.1186/s13100-016-0065-9 · Cited by 670
The multiple pathways to autoimmunity
Theofilopoulos, A. N., Kono, D. H., & Baccala, R. (2017) · Nature Immunology · doi:10.1038/ni.3731 · Cited by 590
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Roers, A., Hiller, B., & Hornung, V. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.002 · Cited by 541
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Metadata
- Authors
- Hung, T., Pratt, G. A., Sundararaman, B., Townsend, M. J., Chaivorapol, C., Bhangale, T., Graham, R. R., Ortmann, W., Criswell, L. A., Yeo, G. W., & Behrens, T. W.
- Venue
- Science
- Published
- 2015-10-23
- Volume
- 350
- Issue
- 6259
- Pages
- 455-459
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2211372197
- Cited by
- 254
- References
- 1
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Hung, T., Pratt, G. A., Sundararaman, B., Townsend, M. J., Chaivorapol, C., Bhangale, T., Graham, R. R., Ortmann, W., Criswell, L. A., Yeo, G. W., & Behrens, T. W. (2015). The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Science. https://doi.org/10.1126/science.aac7442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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