Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span
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Aging: All in the head—and the gut: The effects of hypoxia and caloric restriction, both of which extend life span in Caenorhabditis elegans , converge on the activation of an enzyme in cells of the intestine. Leiser et al. show that the life-extending effects of hypoxia begin in neurons with transcriptional activation by hypoxia-inducible factor–1 and increased serotonergic signaling. These effects lead to increased production of flavin-containing monooxygenase-2 (FMO-2) in the intestine, which increased longevity. Finding the relevant targets of FMO-2, which also accumulates in mammals under conditions that promote longevity, may elucidate further mechanisms that promote healthy aging. Science , this issue p. 1375
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FMO2 has been shown to extend lifespan in Caenorhabditis elegans.
“which has been shown to extend lifespan in Caenorhabditis elegans.68,69”
From Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages (2026) · cites this paper as [69]
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- Authors
- Leiser, S. F., Miller, H., Rossner, R., Fletcher, M., Leonard, A., Primitivo, M., Rintala, N., Ramos, F. J., Miller, D. L., & Kaeberlein, M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Miller, Hillary
- Rossner, Ryan
- Kaeberlein, Matt
- Venue
- Science
- Published
- 2015-12-11
- Volume
- 350
- Issue
- 6266
- Pages
- 1375-1378
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4801033
- OpenAlex
- W2209787832
- Cited by
- 159
- References
- 4
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 18 · 2016: 15
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01AG038518, K99AG045200, T32AG000057, P30AG013280, R00AGA0033050)
- National Institute on Aging
- M. J. Murdock Charitable Trust
- American Federation for Aging Research
- Samsung Advanced Institute of Technology
- Samsung Electronics Co.
- University of Washington Healthy Aging
- Longevity Research Institute
- Ellison Medical Foundation New Scholar in Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
- Keywords
- longevity, healthspan, non-cell-autonomous signaling, serotonin, tph-1, dietary restriction, Caenorhabditis elegans, xenobiotic detoxification
- MeSH terms
- Animals, Diet, Intestines, Longevity, Neurons, Oxygenases, Receptors, Serotonin, Transcription Factors, Tryptophan Hydroxylase, Signal Transduction, Caenorhabditis elegans, Caenorhabditis elegans Proteins, RNA Interference, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Protein Stability
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