Proteostasis and longevity: when does aging really begin?

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

Walter, P., & Ron, D. (2011) · Science · doi:10.1126/science.1209038 · Cited by 5,893 · see citing works

Adapting Proteostasis for Disease Intervention

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008) · Science · doi:10.1126/science.1141448 · Cited by 2,495 · see citing works

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

Finley, D. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081507.101607 · Cited by 1,764 · see citing works

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513 · see citing works

Heat shock factors: integrators of cell stress, development and lifespan

Åkerfelt, M., Morimoto, R. I., & Sistonen, L. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2938 · Cited by 1,457 · see citing works

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works

Signals from the reproductive system regulate the lifespan of C. elegans

Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,015 · see citing works

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

Morimoto, R. I. (2008) · Genes & Development · doi:10.1101/gad.1657108 · Cited by 872 · see citing works

Autophagy in the Cellular Energetic Balance

Singh, R., & Cuervo, A. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.004 · Cited by 788 · see citing works

Stress-activated cap’n’collar transcription factors in aging and human disease

Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

Westerheide, S. D., Anckar, J., Stevens, S. M., Sistonen, L., & Morimoto, R. I. (2009) · Science · doi:10.1126/science.1165946 · Cited by 722 · see citing works

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works

Widespread protein aggregation as an inherent part of aging in C. elegans

David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., & Kenyon, C. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000450 · Cited by 627 · see citing works

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

Taylor, R. C., & Dillin, A. G. (2013) · Cell · doi:10.1016/j.cell.2013.05.042 · Cited by 570 · see citing works

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 433 · see citing works

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

Pérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418 · see citing works

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Vilchez, D., Morantte, I., Liu, Z., Douglas, P. M., Merkwirth, C., Rodrigues, A. P. C., Manning, G., & Dillin, A. (2012) · Nature · doi:10.1038/nature11315 · Cited by 413 · see citing works

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

Lapierre, L. R., Gelino, S., Meléndez, A., & Hansen, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.07.042 · Cited by 343 · see citing works

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

Rana, A., Rera, M., & Walker, D. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216197110 · Cited by 335 · see citing works

Transcriptional Profile of Aging in C. elegans

Lund, J., Tedesco, P. M., Duke, K., Wang, J., Kim, S. K., & Johnson, T. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01146-6 · Cited by 304 · see citing works

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

Keller, J. N., Huang, F. F., & Markesbery, W. R. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00067-1 · Cited by 297 · see citing works

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., & Miura, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01227-08 · Cited by 288 · see citing works

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

Krügel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S. K., Murakami, C. J., Schleit, J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002253 · Cited by 243 · see citing works

Initial Quantitative Proteomic Map of 28 Mouse Tissues Using the SILAC Mouse

Geiger, T., Velic, A., Macek, B., Lundberg, E., Kampf, C., Nagaraj, N., Uhlen, M., Cox, J., & Mann, M. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.024919 · Cited by 235 · see citing works

Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

Blake, M. J., Udelsman, R., Feulner, G. J., Norton, D. D., & Holbrook, N. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9873 · Cited by 219 · see citing works

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

Haynes, C. M., Fiorese, C. J., & Lin, Y. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.02.002 · Cited by 209 · see citing works

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

Riedel, C. G., Dowen, R. H., Lourenco, G. F., Kirienko, N. V., Heimbucher, T., West, J. A., Bowman, S. K., Kingston, R. E., Dillin, A., Asara, J. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2720 · Cited by 207 · see citing works

Fibroblast cultures from healthy centenarians have an active proteasome

Chondrogianni, N., Petropoulos, I., Franceschi, C., Friguet, B., & Gonos, E. S. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00137-6 · Cited by 200 · see citing works

Ribosome-associated chaperones as key players in proteostasis

Preißler, S., & Deuerling, E. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.03.002 · Cited by 189 · see citing works

The Unfolded Protein Response in Secretory Cell Function

Moore, K. A., & Hollien, J. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155644 · Cited by 178 · see citing works

Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

Reis‐Rodrigues, P., Czerwieniec, G., Peters, T. W., Evani, U. S., Alavez, S., Gaman, E. A., Vantipalli, M., Mooney, S. D., Gibson, B. W., Lithgow, G. J., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00765.x · Cited by 174 · see citing works

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

Zhang, P., Judy, M. E., Lee, S., & Kenyon, C. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.013 · Cited by 170 · see citing works

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

Knoefler, D., Thamsen, M., Koniczek, M., Niemuth, N. J., Diederich, A.-K., & Jakob, U. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.016 · Cited by 169 · see citing works

The nascent polypeptide‐associated complex is a key regulator of proteostasis

Kirstein, J., Scior, A., Deuerling, E., & Morimoto, R. I. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.87 · Cited by 163 · see citing works

Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans

Liu, J., Zhang, B., Lei, H., Feng, Z., Liu, J., Hsu, A.-L., & Xu, X. Z. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.007 · Cited by 154 · see citing works

A conserved ubiquitination pathway determines longevity in response to diet restriction

Carrano, A. C., Liu, Z., Dillin, A. G., & Hunter, T. R. (2009) · Nature · doi:10.1038/nature08130 · Cited by 131 · see citing works

A longer and healthier life with TOR down-regulation: genetics and drugs

Bjedov, I., & Partridge, L. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390460 · Cited by 128 · see citing works

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

Shore, D. E., Carr, C. E., & Ruvkun, G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002792 · Cited by 125 · see citing works

Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats

Blake, M. J., Fargnoli, J., Gershon, D., & Holbrook, N. J. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.4.r663 · Cited by 113 · see citing works

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

Liu, G., Rogers, J. V., Murphy, C. T., & Rongo, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.195 · Cited by 110 · see citing works

A photoconvertible reporter of the ubiquitin-proteasome system in vivo

Hamer, G., Matilainen, O., & Holmberg, C. I. (2010) · Nature Methods · doi:10.1038/nmeth.1460 · Cited by 105 · see citing works

The Caenorhabditis elegans Germ Line Regulates Distinct Signaling Pathways to Control Lifespan and Innate Immunity

Alper, S., McElwee, M. K., Apfeld, J., Lackford, B. L., Freedman, J. H., & Schwartz, D. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057323 · Cited by 73 · see citing works

REGγ deficiency promotes premature aging via the casein kinase 1 pathway

Li, L., Zhao, D., Wei, H., Yao, L., Dang, Y., Amjad, A., Xu, J., Liu, J., Guo, L., Li, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308497110 · Cited by 72 · see citing works

Post-eclosion decline in ‘knock-down’ thermal resistance and reduced effect of heat hardening in Drosophila melanogaster

Pappas, C., Hyde, D., Bowler, K., Loeschcke, V., & Sørensen, J. G. (2006) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2006.11.010 · Cited by 33 · see citing works

Microarray analysis of variation in individual aging C. elegans: Approaches and challenges

Golden, T. R., Hubbard, A., & Melov, S. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.034 · Cited by 24 · see citing works

Genetic and pharmacological factors that influence reproductive aging in nematodes

Hughes, S. E., Evason, K. J., Xiong, C., & Kornfeld, K. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030025.eor · Cited by 16 · see citing works

Proteostasis and aging

Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Melentijevic, I., Toth, M. L., Arnold, M. L., Guasp, R. J., Harinath, G., Nguyen, K. C., Taub, D., Parker, J. A., Neri, C., Gabel, C. V., et al. (2017) · Nature · doi:10.1038/nature21362 · Cited by 454 · see citing works

Fibrosis: ultimate and proximate causes

Thannickal, V. J., Zhou, Y., Gaggar, A., & Duncan, S. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74368 · Cited by 241 · see citing works

Endoplasmic reticulum proteostasis impairment in aging

Martínez, G., Duran-Aniotz, C. A., Cabral‐Miranda, F., Vivar, J. P., & Hetz, C. A. (2017) · Aging Cell · doi:10.1111/acel.12599 · Cited by 206 · see citing works

Lifespan-regulating genes in C. elegans

Uno, M., & Nishida, E. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.10 · Cited by 192 · see citing works

Heat shock proteins in neurodegenerative disorders and aging

Leak, R. K. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0243-9 · Cited by 170 · see citing works

Blue Journal Conference. Aging and Susceptibility to Lung Disease

Thannickal, V. J., Murthy, M., Balch, W. E., Chandel, N. S., Meiners, S., Eickelberg, O., Selman, M., Pardo, A., White, E. S., Levy, B. D., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1876pp · Cited by 164 · see citing works

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

Labbadia, J. P., Brielmann, R. M., Neto, M. F., Lin, Y.-F., Haynes, C. M., & Morimoto, R. I. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.038 · Cited by 165 · see citing works

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

Leiser, S. F., Miller, H., Rossner, R., Fletcher, M., Leonard, A., Primitivo, M., Rintala, N., Ramos, F. J., Miller, D. L., & Kaeberlein, M. (2015) · Science · doi:10.1126/science.aac9257 · Cited by 159 · see citing works

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

Melki, R. (2015) · Journal of Parkinson s Disease · doi:10.3233/jpd-150543 · Cited by 147 · see citing works

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

Dattilo, S., Mancuso, C., Koverech, G., Mauro, P. D., Ontario, M. L., Petralia, C. C. T., Petralia, A., Maiolino, L., Serra, A., Calabrese, E. J., et al. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0046-8 · Cited by 140 · see citing works

Impaired proteostasis during skeletal muscle aging

Fernando, R., Drescher, C., Nowotny, K., Grune, T., & Castro, J. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.037 · Cited by 134 · see citing works

The hyperfunction theory: An emerging paradigm for the biology of aging

Gems, D. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101557 · Cited by 129 · see citing works

Mechanisms of neuronal homeostasis: Autophagy in the axon

Maday, S. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.047 · Cited by 123 · see citing works

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

Matai, L., Sarkar, G. C., Chamoli, M., Malik, Y., Kumar, R., Rautela, U., Jana, N. R., Chakraborty, K., & Mukhopadhyay, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900055116 · Cited by 120 · see citing works

Longevity Extension by Phytochemicals

Leonov, A., Arlia‐Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y., & Titorenko, V. I. (2015) · Molecules · doi:10.3390/molecules20046544 · Cited by 100 · see citing works

Tissue-specific autophagy responses to aging and stress in C. elegans

Chapin, H. C., Okada, M., Merz, A. J., & Miller, D. L. (2015) · Aging · doi:10.18632/aging.100765 · Cited by 88 · see citing works

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

Roth, D., Hutt, D. M., Tong, J., Bouchecareilh, M., Wang, N., Seeley, T., Dekkers, J. F., Beekman, J. M., Garza, D., Drew, L., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001998 · Cited by 89 · see citing works

Quality Control of Membraneless Organelles

Alberti, S., & Carra, S. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.013 · Cited by 89 · see citing works

Polyploidy in the adult Drosophila brain

Nandakumar, S., Grushko, O., & Buttitta, L. (2020) · eLife · doi:10.7554/elife.54385 · Cited by 89 · see citing works

Interventions for age-related diseases: Shifting the paradigm

Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works

Drug Discovery in Fish, Flies, and Worms

Strange, K. B. (2016) · ILAR Journal · doi:10.1093/ilar/ilw034 · Cited by 81 · see citing works

Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans

Roux, A. E., Langhans, K. E., Huynh, W., & Kenyon, C. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.024 · Cited by 75 · see citing works

Iron promotes protein insolubility and aging in C. elegans

Klang, I. M., Schilling, B., Sorensen, D. J., Sahu, A. K., Kapahi, P., Andersen, J. K., Swoboda, P., Killilea, D. W., Gibson, B. W., & Lithgow, G. J. (2014) · Aging · doi:10.18632/aging.100689 · Cited by 69 · see citing works

Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

Keith, S. A., Maddux, S., Zhong, Y., Chinchankar, M. N., Ferguson, A. A., Ghazi, A., & Fisher, A. L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005823 · Cited by 58 · see citing works

Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

Koehler, N. K. U., Stransky, E., Meyer, M., Gaertner, S., Shing, M., Schnaidt, M., Celej, M. S., Jovin, T. M., Leyhe, T., Laske, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123444 · Cited by 57 · see citing works

Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians

Emanuele, E., Minoretti, P., Sanchis‐Gomar, F., Pareja-Galeano, H., Yilmaz, Y. N., Garatachea, N., & Lucía, A. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1607 · Cited by 56 · see citing works

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis

Lionaki, E., Gkikas, I., Daskalaki, I., Ioannidi, M.-K., Klapa, M. I., & Tavernarakis, N. (2022) · Nature Communications · doi:10.1038/s41467-022-28272-1 · Cited by 55 · see citing works

Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties

Harel, I., Chen, Y. R., Ziv, I., Singh, P. P., Heinzer, D., Negredo, P. N., Goshtchevsky, U., Wang, W., Astre, G., Moses, E., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.112787 · Cited by 54 · see citing works

Using pharmacological chaperones to restore proteostasis

Wang, Y., Di, X.-J., & Mu, T. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.002 · Cited by 55 · see citing works

Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity

Mack, K. L., & Shorter, J. (2016) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2016.00008 · Cited by 54 · see citing works

Mechanisms of protein balance in skeletal muscle

Anthony, T. G. (2016) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2016.02.012 · Cited by 57 · see citing works

Does senescence promote fitness in Caenorhabditis elegans by causing death?

Lohr, J. N., Galimov, E. R., & Gems, D. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.008 · Cited by 51 · see citing works

Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders

Calabrese, V., Giordano, J., Ruggieri, M., Berritta, D., Salinaro, A. T., Ontario, M. L., Bianchini, R., & Calabrese, E. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23893 · Cited by 50 · see citing works

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Rieckher, M., Markaki, M., Princz, A., Schumacher, B., & Tavernarakis, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.009 · Cited by 46 · see citing works

Reproductive Suicide: Similar Mechanisms of Aging in C. elegans and Pacific Salmon

Gems, D., Kern, C. C., Nour, J., & Ezcurra, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688788 · Cited by 48 · see citing works

Small heat shock proteins in ageing and age-related diseases

Charmpilas, N., Kyriakakis, E., & Tavernarakis, N. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0761-x · Cited by 43 · see citing works

Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis

Sellarés, J., Veraldi, K. L., Thiel, K. J., Cárdenes, N., Álvarez, D., Schneider, F., Pilewski, J. M., Rojas, M. M., & Feghali‐Bostwick, C. A. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0268oc · Cited by 43 · see citing works

ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?

Cabral‐Miranda, F., & Hetz, C. A. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_52 · Cited by 42 · see citing works

Proteasome mapping reveals sexual dimorphism in tissue‐specific sensitivity to protein aggregations

Jenkins, E. C., Shah, N., Gomez-Jenkins, M., Casalena, G., Zhao, D., Kenny, T. C., Guariglia, S. R., Manfredi, G., & Germain, D. (2020) · EMBO Reports · doi:10.15252/embr.201948978 · Cited by 40 · see citing works

J protein mutations and resulting proteostasis collapse

Koutras, C., & Braun, J. E. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00191 · Cited by 36 · see citing works

Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation

Hamilton, K. L., & Miller, B. F. (2017) · The Journal of Physiology · doi:10.1113/jp274335 · Cited by 35 · see citing works

Genetics and Pharmacology of Longevity

Castillo-Quan, J. I., Kinghorn, K. J., & Bjedov, I. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.002 · Cited by 37 · see citing works

Alzheimer‐related protein APL ‐1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans

Ewald, C. Y., Marfil, V., & Li, C. (2016) · Aging Cell · doi:10.1111/acel.12509 · Cited by 32 · see citing works

Perspectives of Homo sapiens lifespan extension: focus on external or internal resources?

Skulachev, V. P., Shilovsky, G. A., Putyatina, T. S., Popov, N. A., Markov, A. V., Skulachev, M. V., & Садовничий, В. А. (2020) · Aging · doi:10.18632/aging.102981 · Cited by 32 · see citing works

The Systems Biology of Single-Cell Aging

Song, R., Sarnoski, E. A., & Açar, M. (2018) · iScience · doi:10.1016/j.isci.2018.08.023 · Cited by 30 · see citing works

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

Sunshine, A. B., Ong, G. T., Nickerson, D. P., Carr, D. T., Murakami, C. J., Wasko, B. M., Shemorry, A., Merz, A. J., Kaeberlein, M. R., & Dunham, M. J. (2016) · Aging Cell · doi:10.1111/acel.12443 · Cited by 29 · see citing works

Intramembrane proteolysis within lysosomes

Schröder, B., & Säftig, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.012 · Cited by 28 · see citing works

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity inC. elegansmodel of Alzheimer's disease

Wang, X., Cao, M., & Dong, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.10857 · Cited by 27 · see citing works

Yeast at the Forefront of Research on Ageing and Age-Related Diseases

Sampaio‐Marques, B., Burhans, W. C., & Ludovico, P. (2019) · Progress in molecular and subcellular biology · doi:10.1007/978-3-030-13035-0_9 · Cited by 26 · see citing works

Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics

Vertti‐Quintero, N., Berger, S., Solvas, X. C. I., Statzer, C., Annis, J., Ruppen, P., Stavrakis, S., Ewald, C. Y., Gunawan, R., & deMello, A. J. (2021) · Small · doi:10.1002/smll.202102145 · Cited by 26 · see citing works

Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases

Cuanalo-Contreras, K., & Moreno‐González, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194666 · Cited by 24 · see citing works

Increased levels of hyper-stable protein aggregates in plasma of older adults

Xia, K., Trasatti, H., Wymer, J. P., & Colón, W. (2016) · AGE · doi:10.1007/s11357-016-9919-9 · Cited by 21 · see citing works

Timeless or tainted? The effects of male ageing on seminal fluid

Fricke, C., Sanghvi, K., Emery, M., Lindenbaum, I., Wigby, S., Ramm, S. A., & Sepil, I. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.1066022 · Cited by 20 · see citing works

Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan

Harkness, T. A. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071888 · Cited by 20 · see citing works

New label‐free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging

Benedetto, A., Bambade, T., Au, C., Tullet, J. M. A., Monkhouse, J. L., Dang, H., Cetnar, K., Chan, B. H. K., Cabreiro, F., & Gems, D. (2019) · Aging Cell · doi:10.1111/acel.12998 · Cited by 20 · see citing works

Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Molière, A., Park, J. Y. C., Goyala, A., Vayndorf, E. M., Zhang, B., Hsiung, K. C., Jung, Y., Kwon, S., Statzer, C., Meyer, D. H., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01232-x · Cited by 19 · see citing works

Deteriorated Stress Response in Stationary-Phase Yeast: Sir2 and Yap1 Are Essential for Hsf1 Activation by Heat Shock and Oxidative Stress, Respectively

Nussbaum, I., Weindling, E., Jubran, R., Cohen, A., & Bar‐Nun, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111505 · Cited by 19 · see citing works

Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP

Kumar, A. V., Kang, T., Thakurta, T. G., Ng, C., Rogers, A. N., Larsen, M. R., & Lapierre, L. R. (2022) · Science Advances · doi:10.1126/sciadv.abj1604 · Cited by 17 · see citing works

Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis

Lee, E. C., Kim, H., Ditano, J. P., Manion, D., King, B. L., & Strange, K. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154156 · Cited by 16 · see citing works

Mechanotransduction through hemidesmosomes during aging and longevity

Ewald, C. Y., & Nyström, A. (2023) · Journal of Cell Science · doi:10.1242/jcs.260987 · Cited by 15 · see citing works

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

Walker, A. C., Bhargava, R., Bucher, M. J., Argote, Y. M., Brust, A. S., & Czyż, D. M. (2024) · iScience · doi:10.1016/j.isci.2024.110828 · Cited by 15 · see citing works

Directional selection coupled with kin selection favors the establishment of senescence

Szilágyi, A., Czárán, T., Mauro Santos, A., & Szathmáry, E. (2023) · BMC Biology · doi:10.1186/s12915-023-01716-w · Cited by 13 · see citing works

Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat

Schneider, J., Han, W. H., Matthew, R., Sauvé, Y., & Lemieux, H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228710 · Cited by 13 · see citing works

Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

Buck, S. A., Mabry, S. J., Glausier, J. R., Banks‐Tibbs, T., Ward, C., Kozel, J., Fu, C., Fish, K. N., Lewis, D. A., Logan, R. W., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02909-1 · Cited by 11 · see citing works

Transcriptional drift in aging cells: A global decontroller

Matsuzaki, T., Weistuch, C., de Graff, A. M. R., Dill, K. A., & Balázsi, G. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401830121 · Cited by 9 · see citing works

What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila

Wodrich, A. P. K., Scott, A. W., & Giniger, E. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111839 · Cited by 9 · see citing works

Gravitational Effects on Human Physiology

Atomi, Y. (2015) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9918-8_29 · Cited by 8 · see citing works

The permanently chaperone-active small heat shock protein Hsp17 from Caenorhabditis elegans exhibits topological separation of its N-terminal regions

Strauch, A., Rossa, B., Köhler, F., Haeussler, S., Mühlhofer, M., Rührnößl, F., Körösy, C., Bushman, Y., Conradt, B., Haslbeck, M., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102753 · Cited by 7 · see citing works

HSF1 Regulation in Aging and Its Role in Longevity

Shemesh, N., & Ben‐Zvi, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55852-1_5 · Cited by 7 · see citing works

Replicative aging impedes stress-induced assembly of a key human protein disaggregasePreprint

Mathangasinghe, Y., Alberts, N., Rosado, C. J., Cox, D., Payne, N. L., Ormsby, A. R., Merve, K., Sakson, R., Uthishtran, S., Ruppert, T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.25.497591 · Cited by 8 · see citing works

Q&A: Trash talk: disposal and remote degradation of neuronal garbage

Arnold, M. L., Melentijevic, I., Smart, A. J., & Driscoll, M. (2018) · BMC Biology · doi:10.1186/s12915-018-0487-6 · Cited by 6 · see citing works

Aggresome-Like Formation Promotes Resistance to Proteotoxicity in Cells from Long-Lived Species

Sunchu, B., Riordan, R., Yu, Z., Almog, I., Dimas-Muñoz, J., Drake, A. C., & Pérez, V. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa069 · Cited by 6 · see citing works

Searching for the elusive mitochondrial longevity signal in C. elegans

Bennett, C. F., Choi, H., & Kaeberlein, M. R. (2014) · Worm · doi:10.4161/21624046.2014.959404 · Cited by 5 · see citing works

End of the Season Blues: Senescence and Reproductive Trade-Offs in Male Scorpions

Vrech, D. E., Oviedo‐Diego, M. A., Olivero, P. A., & Peretti, A. V. (2024) · Insects · doi:10.3390/insects15120916 · Cited by 3 · see citing works

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans

Kyriakakis, E., Medde, C., Ritz, D., Fucile, G., Schmidt, A., & Spang, A. (2025) · Nature Communications · doi:10.1038/s41467-025-63987-x · Cited by 3 · see citing works

Genetic analysis of Caenorhabditis elegans pry-1/Axin suppressors identifies genes involved in reproductive structure development, stress responses, and aging

Mallick, A., Jhaveri, N. S., Jeon, J., Chang, Y., Shah, K., Hosein, H., & Gupta, B. P. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab430 · Cited by 3 · see citing works

Heat shock in the springtime

Morano, K. A., Sistonen, L., & Mezger, V. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0539-y · Cited by 1 · see citing works

Energetic Stress and Proteodynamics in Aging and Longevity

Reid, J. J., Miller, B. F., & Hamilton, K. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00016-4 · Cited by 1 · see citing works

Searching for the elusive mitochondrial longevity signal in C. elegans

Bennett, C. F., Choi, H., & Kaeberlein, M. R. (2014) · Worm · doi:10.4161/worm.29868 · Cited by 1 · see citing works

Invertebrate model organisms for aging research

Shukla, A. K., Scott, A., & Giniger, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00004-5 · Cited by 1 · see citing works

Efficiency of Protein Renewal Is Limited by Feed Intake and Not by Protein Lifetime in Aging Caenorhabditis elegans

Khanijou, J. K., Yee, Z., Raida, M., Lee, J. M., Tay, E. Z. E., Gruber, J., & Walczyk, T. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00383 · Cited by 1 · see citing works

Animal Models for Aging

Lee, E. C., Rogina, B., Haynes, L., & Kuchel, G. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03853-8

Oops! EMS mistakes--they're inevitable, stressful, painful and oh-so educational. This guide helps you classify them and avoid sweating the small stuff.

Murphy, P., & Taigman, M. (1998) · PubMed

Theories of Individual Ageing

Iparraguirre, J. L. (2018) · Springer eBooks · doi:10.1007/978-3-319-93248-4_4

Data mining e caracterização de novos miRNAs com função no envelhecimento de nematoides C. elegans

Arruda, J. R. (2018) · doi:10.47749/t/unicamp.2018.1082948

Metabolically induced neuronal differentiation

Maurer, S. (2022) · doi:10.21248/gups.65941

Efecto de la restricción calórica sobre la conducta sexual masculina, la calidad espermática y las hormonas metabólicas en la rata Wistar longeva

de Jesús, P. L. (2023) · doi:10.24275/uami.pc289j378

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegansPreprint

Kyriakakis, E., Medde, C., Ritz, D., Fucile, G., Schmidt, A., & Spang, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.13.584467

Phenotype Analysis of the CISD Gene Family Relative to Mitochondrial Function in Caenorhabditis elegans

Mungwira, C. F. (2019) · doi:10.12794/metadc1609170

Uzun Yaşam Diyeti

Uzun, E. (2025) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3794

Additional file 1 of Directional selection coupled with kin selection favors the establishment of senescence

Szilágyi, A., Czárán, T., Mauro Santos, A., & Szathmáry, E. (2023) · Figshare · doi:10.6084/m9.figshare.24418979

Modalités d'accumulation des produits de carbamylation des protéines au cours du vieillissement et de l'insuffisance rénale chronique

Gorisse, L. (2014) · doi:10.70675/6dd9f1dczff6fz4506zb681z1db588992502

Development of Inhibitors of Amyloid Fibril Propagation

Bendifallah, M. (2019) · theses.fr (ABES) · doi:10.70675/a872e5bdzc153z41f4z9472z725fd78aab48

Typage moléculaire des maladies neurodégénératives dues à l’agrégation de la protéine alpha synucléine

Fenyi, A. (2019) · theses.fr (ABES) · doi:10.70675/ca9a766cz5bd3z49d3z8d07z7df9d1133f88

Yaşlanma Kader mi? Yaşlanma Biyolojisi ve Genetiği

Lüleyap, H. Ü. (2026) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.4073

E3 Ubiquitin ligases molecular strategies against proteostasis defects of imperfect ageing

Upadhyay, A., Joshi, V., Amanullah, A., Mishra, R., Verma, R. K., Adlakha, Y. K., Suresh, A. K., Dhiman, R., Bhattacharyya, S., & Mishra, A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103319

Genistein as a potential hormetic regulator of proteostasis in neurodegeneration and aging

Dash, R., Mitra, S., Lee, J., Bashar, M. A., Sohel, M., Tran, N.-N., Lee, J.-C., Lee, S. B., & Lee, B. (2026) · Chinese Medical Journal BioMed · doi:10.65457/cmjbm-2026-0009

Insights Into the Links Between Proteostasis and Aging From C. elegans

Zhang, W., Koyuncu, S., & Vı́lchez, D. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.854157 · Cited by 30 · see citing works

Proteostasis and the Aging Proteome in Health and Disease

Morimoto, R. I., & Cuervo, A. M. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu049 · Cited by 277 · see citing works

The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease

Kikis, E. A. (2016) · Biology Direct · doi:10.1186/s13062-016-0161-2 · Cited by 16 · see citing works

The proteostasis network and its decline in ageing

Hipp, M. S., Kasturi, P., & Hartl, F. U. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0101-y · Cited by 1,642 · see citing works

Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649 · see citing works