The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Broadly targeted CD8 + T cell responses restricted by major histocompatibility complex E
Open accessAbstract
An unconventional route to protection: One promising approach toward an HIV-1 vaccine involves infecting people with cytomegalovirus engineered to express proteins from HIV-1. This approach, which works by eliciting virus-killing CD8 + T cells, provides robust protection in nonhuman primate models. Hansen et al. have found out why this approach is so effective. Normally, peptide antigens presented by major histocompatibility complex-1a (MHC-Ia) activate CD8 + T cells. In vaccinated monkeys, however, CD8 + T cells reacted to peptide antigens presented by MHC-E molecules instead. Moreover, MHC-E could present a much wider range of peptides than MHC-Ia. Science , this issue p. 714
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Towards a systems understanding of MHC class I and MHC class II antigen presentation
Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology · doi:10.1038/nri3084 · Cited by 2,044
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HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells
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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10335-5 · Cited by 556
CD8+ T cells in HIV control, cure and prevention
Collins, D. R., Gaiha, G. D., & Walker, B. D. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0274-9 · Cited by 303
Moyo, N., Vogel, A. B., Buus, S., Erbar, S., Wee, E. G., Sahin, U., & Hanke, T. (2019) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.10.010 · Cited by 94
MHC-E–Restricted CD8+ T Cells Target Hepatitis B Virus–Infected Human Hepatocytes
Burwitz, B. J., Hashiguchi, P. K., Mansouri, M., Meyer, C., Gilbride, R. M., Biswas, S., Womack, J. L., Reed, J. S., Wu, H. L., Axthelm, M. K., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900795 · Cited by 24
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Metadata
- Authors
- Hansen, S. G., Wu, H. L., Burwitz, B. J., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Gillespie, G. M., Walters, L. C., Brackenridge, S., Sharpe, H. R., López, C. A., Früh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. B., & Picker, L. J.
- Venue
- Science
- Published
- 2016-02-12
- Volume
- 351
- Issue
- 6274
- Pages
- 714-720
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2284841043
- Cited by
- 290
- References
- 1
- FWCI
- 21.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Hansen, S. G., Wu, H. L., Burwitz, B. J., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Gillespie, G. M., Walters, L. C., . . . Picker, L. J. (2016). Broadly targeted CD8 + T cell responses restricted by major histocompatibility complex E. Science. https://doi.org/10.1126/science.aac9475
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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