The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
Open accessAbstract
Visualizing the beginnings of melanoma: In cancer biology, a tumor begins from a single cell within a group of precancerous cells that share genetic mutations. Kaufman et al. used a zebrafish melanoma model to visualize cancer initiation (see the Perspective by Boumahdi and Blanpain). They used a fluorescent reporter that specifically lit up neural crest progenitors that are only present during embryogenesis or during adult melanoma tumor formation. The appearance of this tumor correlated with a set of gene regulatory elements, called super-enhancers, whose identification and manipulation may prove beneficial in detecting and preventing melanoma initiation. Science , this issue p. 10.1126/science.aad2197 ; see also p. 453
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“Examining multiple normal and cancer cell types (66 and 18 types, respectively), the enrichment of H3K27Ac signal at SOX10 was significant and specific to melanoma cells, hNCC’s, and brain tissue, which contains SOX10-expressing oligodendrocytes (Fig 4E) (26).”
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Hallmarks of Cancer: New Dimensions
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Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
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Self-citationTumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
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Clinical and Therapeutic Implications of Cancer Stem Cells
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Thyroid hormone regulates distinct paths to maturation in pigment cell lineages
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Metadata
- Authors
- Kaufman, C. K., Mosimann, C., Fan, Z. P., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Young, R. A., & Zon, L. I.
- Venue
- Science
- Published
- 2016-01-29
- Volume
- 351
- Issue
- 6272
- Pages
- aad2197-aad2197
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2268569236
- Cited by
- 398
- References
- 49
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaufman, C. K., Mosimann, C., Fan, Z. P., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Young, R. A., & Zon, L. I. (2016). A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. https://doi.org/10.1126/science.aad2197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
