The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
Abstract
Antibodies block Ebola virus entry: The recent Ebola virus outbreak in West Africa illustrates the need for both an effective vaccine and therapies to treat infected individuals. Corti et al. isolated two monoclonal antibodies from a survivor of the 1995 Kikwit outbreak and demonstrated their therapeutic efficacy in Ebola virus–infected macaques. In fact, one antibody protected macaques when it was given up to 5 days after infection. Misasi et al. solved the crystal structures of fragments of the two antibodies bound to the Ebola virus glycoprotein (GP), which mediates viral cell entry. The two antibodies targeted different regions of GP, but in both cases blocked steps required for viral entry. Science , this issue pp. 1339 & 1343
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Citations
Cites
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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
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Self-citationSmall molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection
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Self-citationBarouch, D. H., Whitney, J. B., Moldt, B., Klein, F., Oliveira, T. Y., Liu, J., Stephenson, K. E., Chang, H.-W., Shekhar, K., Gupta, S., et al. (2013) · Nature · doi:10.1038/nature12744 · Cited by 644
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Cited by
Development of therapeutic antibodies for the treatment of diseases
Lu, R.-M., Hwang, Y.-C., Liu, I.-J., Lee, C.-C., Tsai, H.-Z., Li, H.-J., & Wu, H.-C. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-019-0592-z · Cited by 2,085
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Pinto, D., Park, Y.-J., Beltramello, M., Walls, A. C., Tortorici, M. A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2349-y · Cited by 1,885
Self-citationStructural and functional analysis of a potent sarbecovirus neutralizing antibody
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Self-citationA Randomized, Controlled Trial of Ebola Virus Disease Therapeutics
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Metadata
- Authors
- Corti, D., Misasi, J., Mulangu, S., Stanley, D. A., Kanekiyo, M., Wollen, S., Ploquin, A., Doria-Rose, N. A., Staupe, R. P., Bailey, M., Shi, W., Choe, M., Marcus, H., Thompson, E. A., Cagigi, A., Silacci, C., Fernandez-Rodriguez, B., Perez, L., Sallusto, F., Vanzetta, F., Agatic, G., Cameroni, E., Kisalu, N., Gordon, I., Ledgerwood, J. E., Mascola, J. R., Graham, B. S., Muyembe-Tamfun, J.-J., Trefry, J. C., Lanzavecchia, A., & Sullivan, N. J.
- Venue
- Science
- Published
- 2016-03-18
- Volume
- 351
- Issue
- 6279
- Pages
- 1339-1342
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2288202420
- Cited by
- 408
- References
- 22
- FWCI
- 40.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Corti, D., Misasi, J., Mulangu, S., Stanley, D. A., Kanekiyo, M., Wollen, S., Ploquin, A., Doria-Rose, N. A., Staupe, R. P., Bailey, M., Shi, W., Choe, M., Marcus, H., Thompson, E. A., Cagigi, A., Silacci, C., Fernandez-Rodriguez, B., Perez, L., Sallusto, F., . . . Sullivan, N. J. (2016). Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody. Science. https://doi.org/10.1126/science.aad5224
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
