The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature
Open accessAbstract
Altered fluid flow causes curved spine: Adolescent idiopathic scoliosis is characterized by three-dimensional spinal curves and affects 3% of the world's children. However, the biological basis of this condition is unclear. Grimes et al. studied zebrafish models that likewise display a curved spine. Defects in the formation and function of motile cilia in the central nervous system perturbed the flow of cerebrospinal fluid (CSF), leading to abnormal spinal curvatures as the fish grew. Curves could be partially rescued by restoring CSF flow, suggesting potential therapeutic strategies if the same mechanism is shared in humans. Science , this issue p. 1341
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs
Kwan, K. M., Fujimoto, E., Grabher, C., Mangum, B. D., Hardy, M. E., Campbell, D. S., Parant, J. M., Yost, H. J., Kanki, J. P., & Chien, C. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21343 · Cited by 1,774
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
Jao, L.-E., Wente, S. R., & Chen, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308335110 · Cited by 1,311
Chiari I Malformation Redefined: Clinical and Radiographic Findings for 364 Symptomatic Patients
Milhorat, T. H., Chou, M. W., Trinidad, E. M., Kula, R. W., Mandell, M., Wolpert, C., & Speer, M. C. (1999) · Neurosurgery · doi:10.1097/00006123-199905000-00042 · Cited by 1,305
The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle
Singla, V., & Reiter, J. F. (2006) · Science · doi:10.1126/science.1124534 · Cited by 1,189
Adolescent idiopathic scoliosis
Cheng, J. C., Castelein, R. M., Chu, W. C., Danielsson, A. J., Dobbs, M. B., Grivas, T. B., Gurnett, C. A., Luk, K. D., Moreau, A., Newton, P. O., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.30 · Cited by 683
Park, T. J., Mitchell, B. J., Abitua, P. B., Kintner, C., & Wallingford, J. B. (2008) · Nature Genetics · doi:10.1038/ng.104 · Cited by 459
Conserved function for embryonic nodal cilia
Essner, J. J., Vogan, K. J., Wagner, M. K., Tabin, C. J., Yost, H. J., & Brueckner, M. (2002) · Nature · doi:10.1038/418037a · Cited by 375
Switching on cilia: transcriptional networks regulating ciliogenesis
Choksi, S. P., Lauter, G., Swoboda, P., & Roy, S. (2014) · Development · doi:10.1242/dev.074666 · Cited by 358
Cited by
Planar cell polarity in development and disease
Butler, M. T., & Wallingford, J. B. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.11 · Cited by 580
The development and functions of multiciliated epithelia
Spassky, N., & Meunier, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.21 · Cited by 389
Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert syndrome
Latour, B. L., Van De Weghe, J. C., Rusterholz, T. D. S., Letteboer, S. J. F., Gomez, A., Shaheen, R., Gesemann, M., Karamzade, A., Asadollahi, M., Barroso-Gil, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131656 · Cited by 76
Chrystal, P. W., Lambacher, N. J., Doucette, L. P., Bellingham, J., Schiff, E. R., Noel, N. C. L., Li, C., Tsiropoulou, S., Casey, G. A., Zhai, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33820-w · Cited by 31
Metadata
- Authors
- Grimes, D. T., Boswell, C. W., Morante, N. F. C., Henkelman, R. M., Burdine, R. D., & Ciruna, B.
- Venue
- Science
- Published
- 2016-06-10
- Volume
- 352
- Issue
- 6291
- Pages
- 1341-1344
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2416325988
- Cited by
- 294
- References
- 27
- FWCI
- 27.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. https://app.cochat.ai/papers/10.1126/science.aaf6419
- The paper
- Grimes, D. T., Boswell, C. W., Morante, N. F. C., Henkelman, R. M., Burdine, R. D., & Ciruna, B. (2016). Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science. https://doi.org/10.1126/science.aaf6419
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
