The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Switching on cilia: transcriptional networks regulating ciliogenesis
Open accessAbstract
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
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Cites
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331
An atlas of combinatorial transcriptional regulation in mouse and man
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Morphogenesis of the murine node and notochordal plate
Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K., & Schoenwolf, G. C. (1994) · Developmental Dynamics · doi:10.1002/aja.1002010309 · Cited by 338
Vij, S., Rink, J. C., Ho, H. K., Babu, D., Eitel, M., Narasimhan, V., Tiku, V., Westbrook, J., Schierwater, B., & Roy, S. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003019 · Cited by 65
Self-citationZhang, D., Stumpo, D. J., Graves, J. P., DeGraff, L. M., Grissom, S. F., Collins, J. B., Li, L., Zeldin, D. C., & Blackshear, P. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03930.x · Cited by 37 · cited 3×
“…suggesting that besides playing an essential role in promoting ciliogenesis, the RFX factors could also be directly involved in the specification of the ciliated cell types (Burghoorn et al., 2012; Efimenko et al., 2005; Zhang et al., 2006), a hypothesis that clearly requires further exploration.”
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Cited by
The Human Transcription Factors
Lambert, S. A., Jolma, A., Campitelli, L. F., Das, P. K., Yin, Y., Albu, M., Chen, X., Taipale, J., Hughes, T. R., & Weirauch, M. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.029 · Cited by 3,399
Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588
Respiratory epithelial cells orchestrate pulmonary innate immunity
Whitsett, J. A., & Alenghat, T. (2015) · Nature Immunology · doi:10.1038/ni.3045 · Cited by 801
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
Kessler, M., Hoffmann, K., Brinkmann, V., Thieck, O., Jackisch, S., Toelle, B., Berger, H., Mollenkopf, H.-J., Mangler, M., Sehouli, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9989 · Cited by 459
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Metadata
- Authors
- Choksi, S. P., Lauter, G., Swoboda, P., & Roy, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-04-01
- Volume
- 141
- Issue
- 7
- Pages
- 1427-1441
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2138069365
- Cited by
- 358
- References
- 6
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Choksi, S. P., Lauter, G., Swoboda, P., & Roy, S. (2014). Switching on cilia: transcriptional networks regulating ciliogenesis. Development. https://doi.org/10.1242/dev.074666
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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