RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong +13 more·2016·Science

Cited by (611)

Items 101–200 of 611

  1. Research trends, hot spots and prospects for necroptosis in the field of neuroscience
    Kun Xiong, Weitao Yan, Shuang Lu, Yandi Yang, Wen-Ya Ning, Yan Cai, Xi-Min Hu, Qí Zhāng · 2021 · Neural Regeneration Research
  2. Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress
    Sabira Mohammed, Evan H. Nicklas, Nidheesh Thadathil, Ramasamy Selvarani, Gordon H. Royce, Michael T Kinter, Arlan G Richardson, Sathyaseelan S. Deepa · 2021 · Free Radical Biology and Medicine
  3. Current translational potential and underlying molecular mechanisms of necroptosis
    Tamás Molnár, Anett Mázló, Vera Tslaf, Attila Gábor Szöllősi, Gabriella Emri, Gábor Koncz · 2019 · Cell Death and Disease
  4. Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration
    Shen’ao Zhou, Wei Zhang, Gaihong Cai, Yingzhe Ding, C. Wei, Sheng Li, Yu Yang, J. Qin, Dan Liu, Hao Zhang et al. · 2020 · Cell Research
  5. The role of necroptosis in disease and treatment
    Xiaoxiao Liu, Xin Xie, Yuanyuan Ren, Zhiying Shao, Nie Zhang, Liantao Li, Xin Ding, Longzhen Zhang · 2021 · MedComm
  6. RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease
    Qingsong Lin, Ping Chen, Wei-Xiong Wang, Chen-Chao Lin, Yao Zhou, Lianghong Yu, Yuanxiang Lin, Yanfang Xu, De-Zhi Kang · 2019 · Laboratory Investigation
  7. ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
    Slawomir A. Dziedzic, Zhenyi Su, Vica Jean Barrett, Ayaz Najafov, Adnan Kasim Mookhtiar, Palak P. Amin, Heling Pan, Li Sun, Hong Zhu, Averil I. Ma et al. · 2017 · Nature Cell Biology
  8. The Peripheral Immune System and Amyotrophic Lateral Sclerosis
    Pamela McCombe, John D. Lee, Trent M. Woodruff, Robert D. Henderson · 2020 · Frontiers in Neurology
  9. Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms
    Andrea Markovinović, Raffaello Cimbro, Tereza Ljutić, Jasna Križ, Boris Rogelj, Ivana Munitić · 2017 · Progress in Neurobiology
  10. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation
    Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi et al. · 2021 · Cell Research
  11. Programmed Cell Death in Sepsis Associated Acute Kidney Injury
    Zhifen Wu, Junhui Deng, Hongwen Zhou, Wei Tan, Lirong Lin, Jurong Yang · 2022 · Frontiers in Medicine
  12. Pharmacotherapy for Amyotrophic Lateral Sclerosis: A Review of Approved and Upcoming Agents
    Stephen A. Johnson, Ton Fang, Fabiola De Marchi, Dylan V. Neel, Donatienne Van Weehaeghe, James D. Berry, Sabrina Paganoni · 2022 · Drugs
  13. Necroptosis pathways in tumorigenesis
    Tao Zhang, Yingnan Wang, Hiroyuki Inuzuka, Wenyi Wei · 2022 · Seminars in Cancer Biology
  14. Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury
    Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang et al. · 2018 · Molecular Cell
  15. Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB
    Tsui-Wen Chou, Nydia P. Chang, Medha Krishnagiri, Aisha P. Patel, Marissa Lindman, Juan P. Angel, Po-Lun Kung, Colm Atkins, Brian P. Daniels · 2021 · Cell Death and Disease
  16. Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death
    Jarama Clucas, Pascal Meier · 2023 · Nature Reviews Molecular Cell Biology
  17. Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination
    Jia Wang, Wan Yun Ho, Kenneth Lim, Jia Feng, Greg Tucker‐Kellogg, Klaus‐Armin Nave, Shuo‐Chien Ling · 2018 · Proceedings of the National Academy of Sciences
  18. BRAF and AXL oncogenes drive RIPK3 expression loss in cancer
    Ayaz Najafov, Ioannis K. Zervantonakis, Adnan Kasim Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes et al. · 2018 · PLoS Biology
  19. Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct
    Huihui Huang, William W. Jin, Ming Huang, Heyu Ji, Diane E. Capen, Yin Yan Xia, Junying Yuan, Teodor G. Păunescu, Hua A. Jenny Lu · 2020 · Journal of the American Society of Nephrology
  20. The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
    Heike J. Wobst, Korrie L. Mack, Dean G. Brown, Nicholas J. Brandon, James Shorter · 2020 · Medicinal Research Reviews
  21. Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives
    Stefano Raffaele, Marta Boccazzi, Marta Fumagalli · 2021 · Cells
  22. Inflammasome assembly in neurodegenerative diseases
    Singh, Jagjit, Habean, Maria L., Panicker, Nikhil · 2023 · Trends in Neurosciences
  23. c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration
    Murata, Hitoshi, Khine, Cho Cho, Nishikawa, Akane, Yamamoto, Ken-ichi, Kinoshita, Rie, Sakaguchi, Masakiyo · 2018 · Journal of Biological Chemistry
  24. The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3
    Xialian Wu, Yeyang Ma, Kun Zhao, Jing Zhang, Yunpeng Sun, Yichen Li, Xing-Qi Dong, Hong Hu, Jing Liu, Jian Wang et al. · 2021 · Proceedings of the National Academy of Sciences
  25. Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery
    Wu, Xiaolei, Yang, Zhangzhong, Zou, Jinjun, Gao, Huile, Shao, Zhenhua, Li, Chuanzhou, Lei, Peng · 2025 · Signal Transduction and Targeted Therapy
  26. In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model
    Xue Zhang, Fengchao Wang, Yi Hu, Runze Chen, Dawei Meng, Liang Guo, Hailong Lv, Ji‐Song Guan, Yichang Jia · 2020 · Brain
  27. Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
    Natalia Salvadores, Inés Moreno‐González, Nazaret Gamez, Gabriel Quiroz, Laura Vegas‐Gomez, Marcela Escandón, Sebastián Jiménez, Javier Vitórica, Antonia Gutiérrez, Claudio A. Soto et al. · 2022 · Acta Neuropathologica Communications
  28. Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases
    Dong Guo, Zhihao Liu, Jinglin Zhou, Chongrong Ke, Daliang Li · 2024 · International Journal of Molecular Sciences
  29. Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS
    Taide Wang, Nirma D. Perera, Mathew D. F. Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, André L. Samson, Wayne Cawthorne, Eric N. Valor, James M. Murphy et al. · 2019 · Cell Death and Differentiation
  30. Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425
    Langtao Guo, Xueping Zheng, Enwei Wang, Xusheng Jia, Gang Wang, Jian Wen · 2020 · Biomedicine & Pharmacotherapy
  31. Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
    Stanley H. Appel, David R. Beers, Weihua Zhao · 2021 · Current Opinion in Neurology
  32. Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions
    Min‐Young Noh, Hyuk Sung Kwon, Min‐Soo Kwon, Minyeop Nahm, Hee Kyung Jin, Jae‐sung Bae, Seung Hyun Kim · 2025 · Molecular Neurodegeneration
  33. Selective Autophagy Receptors in Neuronal Health and Disease
    Conway, Owen, Akpinar, Hafize Aysin, Rogov, Vladimir V., Kirkin, Vladimir · 2020 · Journal of Molecular Biology
  34. Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
    Hongbo Chen, Mark W. Kankel, Susan C. Su, Steve Han, Dimitry Ofengeim · 2018 · Cell Death and Differentiation
  35. Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis
    Diego E. Hernández, Natalia Salvadores, Guillermo Moya‐Alvarado, Romina J. Catalán, Francisca C. Bronfman, Felipe A. Court · 2018 · Journal of Cell Science
  36. Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation
    Yue Zhang, Ming Li, Xiaoming Li, Haiwei Zhang, Lingxia Wang, Xiaoxia Wu, Haibing Zhang, Yan Luo · 2020 · Cell Death and Disease
  37. A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis
    Lauren Mifflin, Zhirui Hu, Connor Dufort, Cynthia C. Hession, Alec J. Walker, Kongyan Niu, Hong Zhu, Nan Liu, Jun S. Liu, Joshua Z. Levin et al. · 2021 · Proceedings of the National Academy of Sciences
  38. Functions of Astrocytes under Normal Conditions and after a Brain Disease
    Soraya L. Vallés, Sandeep Kumar Singh, Juan Campos-Campos, Carlos Colmena, Ignacio Campo-Palacio, Kenia Alvarez-Gamez, Óscar Caballero, Adrián Jorda · 2023 · International Journal of Molecular Sciences
  39. Genetic Regulation of RIPK1 and Necroptosis
    Daichao Xu, Chengyu Zou, Junying Yuan · 2021 · Annual Review of Genetics
  40. Candidate genes in gastric cancer identified by constructing a weighted gene co-expression network
    Jian Chen, Xiuwen Wang, Bing Hu, Yifu He, Xiaojun Qian, Wei Wang · 2018 · PeerJ
  41. Necroptosis increases with age in the brain and contributes to age-related neuroinflammation
    Nidheesh Thadathil, Evan H. Nicklas, Sabira Mohammed, Tommy L. Lewis, Arlan G Richardson, Sathyaseelan S. Deepa · 2021 · GeroScience
  42. OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
    Joshua M. Ames, Tejabhiram Yadavalli, Rahul K. Suryawanshi, James Hopkins, Alex M. Agelidis, Chandrashekhar Devidas Patil, Brian Fredericks, Henry C. Tseng, Tibor Vályi-Nagy, Deepak Shukla · 2021 · Nature Communications
  43. Axonal Degeneration Is Mediated by Necroptosis Activation
    Macarena S. Arrázola, Cristian Saquel, Romina J. Catalán, Sebastián A. Barrientos, Diego E. Hernández, Nicolás W. Martínez, Alejandra Catenaccio, Felipe A. Court · 2019 · Journal of Neuroscience
  44. Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE
    Tong‐Fei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, Lu-Lin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou et al. · 2020 · The Journal of Experimental Medicine
  45. The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
    Sriram Balusu, Bart De Strooper · 2024 · Acta Neuropathologica
  46. Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases
    Chunhui Huang, Sen Yan, Zaijun Zhang · 2020 · Translational Neurodegeneration
  47. Necroptosis: A Pathogenic Negotiator in Human Diseases
    Hitesh Singh Chaouhan, Ch. Vinod, Nikita Mahapatra, Shaohua Yu, I‐Kuan Wang, Kuen‐Bao Chen, Tung‐Min Yu, Chi‐Yuan Li · 2022 · International Journal of Molecular Sciences
  48. The potential role of necroptosis in clinical diseases (Review)
    Wenli Dai, Jin Quan Cheng, Xi Leng, Xiaoqing Hu, Yingfang Ao · 2021 · International Journal of Molecular Medicine
  49. Necroptosis in heart disease: Molecular mechanisms and therapeutic implications
    Xiaoyun Guo, Yi Chen, Qinghang Liu · 2022 · Journal of Molecular and Cellular Cardiology
  50. Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?
    Ming Yang, Kwok‐Fai So, Wai‐Ching Lam, Acy Lo · 2020 · International Journal of Molecular Sciences
  51. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
    Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Zuolong Liu, Zuolong Liu, Qiang Gao, Ping An et al. · 2023 · Molecular Neurodegeneration
  52. The Links between ALS and NF-κB
    Emma Källstig, Brian D. McCabe, Bernard Laurent Schneider · 2021 · International Journal of Molecular Sciences
  53. The GM2 gangliosidoses: Unlocking the mysteries of pathogenesis and treatment
    Camilo Toro, Mosufa Zainab, Cynthia J. Tifft · 2021 · Neuroscience Letters
  54. Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response
    Wanjin Li, Bing Shan, Chengyu Zou, Huibing Wang, Mengmeng Zhang, Hong Zhu, Masanori Gomi Naito, Daichao Xu, Vica Jean Manuel, Lauren Mifflin et al. · 2022 · Cell Research
  55. RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models
    Do‐Yeon Kim, Yea‐Hyun Leem, Jin‐Sun Park, Jung‐Eun Park, Jae‐Min Park, Jihee Lee Kang, Hee-Sun Kim · 2023 · Cells
  56. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
    Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue · 2017 · Molecular Neurodegeneration
  57. c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities
    Mengtao Cao, Fei Chen, Ni Xie, Meng-Yao Cao, Pengfei Chen, Qi Lou, Yanli Zhao, Chen He, Shuyuan Zhang, Xinyang Song et al. · 2018 · Cell Death and Disease
  58. ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death
    Zhengzhao Liu, Hongming Li, Chun‐Gu Hong, Menglu Chen, Tao Yue, Chunyuan Chen, Zhen‐Xing Wang, Qing You, Chuanyin Li, Qinjie Weng et al. · 2018 · Frontiers in Immunology
  59. Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
    Ramya Ranganathan, Shaila Haque, Kayesha Coley, Stephanie R. Shepheard, Johnathan Cooper‐Knock, Janine Kirby · 2020 · Frontiers in Neuroscience
  60. Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease
    Caroline Benn, Lee A. Dawson · 2020 · Frontiers in Aging Neuroscience
  61. Targeting RIPK1 kinase for modulating inflammation in human diseases
    Wanjin Li, Junying Yuan · 2023 · Frontiers in Immunology
  62. Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?
    Rita Moretti, Paola Caruso · 2020 · International Journal of Molecular Sciences
  63. Implications of Selective Autophagy Dysfunction for ALS Pathology
    Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patrício Manque, Melissa Nassif, Ute Woehlbier · 2020 · Cells
  64. Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options
    Fatemeh Yarmohammadi, Hedyieh Karbasforooshan, Andrew Wallace Hayes, Gholamreza Karimi · 2021 · Naunyn-Schmiedeberg s Archives of Pharmacology
  65. Proteomic analysis of necroptotic extracellular vesicles
    Inbar Shlomovitz, Ziv Erlich, Gali Arad, Liat Edry‐Botzer, Sefi Zargarian, Hadar Cohen, Tal Manko, Yifat Ofir‐Birin, Tomer Cooks, Neta Regev‐Rudzki et al. · 2021 · Cell Death and Disease
  66. Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease
    Ziwen Song, Xingxing Xie, Yulu Chen, Boxin Zhang, Xingyan Li, Yuanxin Yang, Wei Mo, Jian Zhang, Daichao Xu · 2025 · Immunity
  67. The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
    Wenting Guo, Tijs Vandoorne, Jolien Steyaert, Kim A. Staats, Ludo Van Den Bosch · 2020 · Brain
  68. Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression
    Júlia Canet-Pons, Nesli-Ece Şen, Aleksandar Arsović, Luis Enrique Almaguer-Mederos, Melanie Vanessa Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel et al. · 2021 · Neurobiology of Disease
  69. Targeting Cell Membranes, Depleting ROS by Dithiane and Thioketal-Containing Polymers with Pendant Cholesterols Delivering Necrostatin-1 for Glaucoma Treatment
    Rong Rong, Xuezhi Zhou, Ganghao Liang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Haihua Xiao, Dan Ji, Xiaobo Xia · 2022 · ACS Nano
  70. Quantitative patterns of motor cortex proteinopathy across ALS genotypes
    Matthew Nolan, Connor Scott, Menuka M. Pallebage‐Gamarallage, Daniel Lunn, Kilda Carpenter, Elizabeth McDonough, Dan E. Meyer, Sireesha Kaanumalle, Alberto Santamaría-Pang, Martin R. Turner et al. · 2020 · Acta Neuropathologica Communications
  71. Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases.
    2020 · International Review of Cell and Molecular Biology
  72. Aging-Dependent Mitophagy Dysfunction in Alzheimer’s Disease
    Mingxue Song, Xiulan Zhao, Fuyong Song · 2021 · Molecular Neurobiology
  73. Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities
    Ruxin Zhang, Yanrong Song, Xuefeng Su · 2022 · Journal of Alzheimer s Disease
  74. Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
    Martin Rübbelke, Dennis Fiegen, Margit Bauer, Florian P. C. Binder, James Y. Hamilton, Jim King, Sven Thamm, Herbert Nar, Markus Zeeb · 2020 · Proceedings of the National Academy of Sciences
  75. The interplay of autophagy and non-apoptotic cell death pathways
    2020 · International Review of Cell and Molecular Biology
  76. NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
    Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan et al. · 2021 · Nature Communications
  77. Necroptosis in amyotrophic lateral sclerosis and other neurological disorders
    Jessica R. Morrice, Cheryl Y. Gregory, Christopher A. Shaw · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  78. Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites
    Dan E. McNamara, Cole M. Dovey, Andrew T. Hale, Giovanni Quarato, Christy R. Grace, Cristina D. Guibao, Jonathan Diep, Amanda Nourse, Casey Cai, Hong Wu et al. · 2019 · Cell chemical biology
  79. Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential
    Justin You, Mohieldin Youssef, Jhune Rizsan Santos, Jooyun Lee, Jeehye Park · 2023 · Biology
  80. Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis
    Eduardo Reynoso, Hua Liu, Lin Li, Anthony L. Yuan, She Chen, Zhigao Wang · 2017 · Journal of Biological Chemistry
  81. Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants
    Agnès Hincelin-Méry, Xavier Nicolas, Cathy Cantalloube, Robert J. Pomponio, Pascale Lewanczyk, Myriam Bénamor, Dimitry Ofengeim, Emmanuel Krupka, Jennifer Hsiao‐Nakamoto, Amy Eastenson et al. · 2023 · Clinical and Translational Science
  82. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens
    Tsuyoshi Ishii, Takuro Okai, Misa Iwatani-Yoshihara, Manabu Mochizuki, Satoko Unno, Masako Kuno, Masato Yoshikawa, Sachio Shibata, Masanori Nakakariya, Takatoshi Yogo et al. · 2017 · Scientific Reports
  83. Protein kinase inhibitors for amyotrophic lateral sclerosis therapy
    Valle Palomo, Vanesa Nozal, Elisa Rojas‐Prats, Carmen Gil, Ana Martı́nez · 2020 · British Journal of Pharmacology
  84. Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment
    Shang Li, Lailiang Qu, Xiaobing Wang, Lingyi Kong · 2021 · Pharmacology & Therapeutics
  85. Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice
    Long‐Long Cao, Pei-Pei Guan, Shen-Qing Zhang, Yi Yang, Xueshi Huang, Pu Wang · 2021 · Journal of Neuroinflammation
  86. Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective
    Shaojun Shi, Monique M. A. Verstegen, Laura Mezzanotte, Jeroen de Jonge, Clemens W.G.M. Löwik, Luc J. W. van der Laan · 2019 · Liver Transplantation
  87. Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury
    Yu Ming Xu, Yibo Geng, Hui Wang, Haojie Zhang, Jianjun Qi, Feida Li, Xinli Hu, Yituo Chen, Haipeng Si, Yao Li et al. · 2023 · Redox Biology
  88. The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death
    Natascia Guida, Giusy Laudati, Angelo Serani, Luigi Mascolo, Pasquale Molinaro, Paolo Montuori, Gianfranco Di Renzo, Lorella M.T. Canzoniero, Luigi Formisano · 2017 · Biochemical Pharmacology
  89. Necroptosis increases with age and is reduced by dietary restriction
    Sathyaseelan S. Deepa, Archana Unnikrishnan, Stephanie Matyi, Niran Hadad, Arlan G Richardson · 2018 · Aging Cell
  90. PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signaling pathway activation
    Shiping Hu, Xixi Chang, Hongbin Zhu, Dongxu Wang, Guozhu Chen · 2020 · Cytokine
  91. Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy
    Dan Ke, Zhen Zhang, Jieting Liu, Peijian Chen, Jialing Li, Xinhai Sun, Yanhui Chu, Luxin Li · 2023 · Frontiers in Cardiovascular Medicine
  92. Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
    Fabiola De Marchi, Ivana Munitić, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Gabriela Novotni, Boris Rogelj, Vladimira Vuletić et al. · 2023 · Biomedicines
  93. Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
    Georgia Dermentzaki, Kristin A. Politi, Lei Lü, Vartika R. Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann, Francesco Lotti, Neil A. Shneider, Serge Przedborski · 2019 · eNeuro
  94. Astrocyte‐specific deletion of the mitochondrial m‐AAA protease reveals glial contribution to neurodegeneration
    Sara Murru, Simon Heß, Esther Barth, Eva-Ruxandra Almajan, Désirée Schatton, Steffen Hermans, Susanne Brodesser, Thomas Langer, Peter Kloppenburg, Elena I. Rugarli · 2019 · Glia
  95. Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
    Isaac G. Onyango, James P. Bennett, Gorazd Bernard Stokin · 2021 · Neural Regeneration Research
  96. HSP90α Mediates Sorafenib Resistance in Human Hepatocellular Carcinoma by Necroptosis Inhibition under Hypoxia
    Yan Liao, Yue Yang, Di Pan, Youxiang Ding, Heng Zhang, Yuting Ye, Jia Li, Li Zhao · 2021 · Cancers
  97. Neuroinflammation in Amyotrophic Lateral Sclerosis: Role of Redox (dys)Regulation
    Nadia D’Ambrosi, Mauro Cozzolino, Maria Teresa Carrı̀ · 2017 · Antioxidants and Redox Signaling
  98. Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease
    Wong, Sing-Wai, Huang, Bo-Wen, Hu, Xiangxiang, Ho Kim, Eui, Kolb, Joseph P., Padilla, Ricardo J., Xue, Peng, Wang, Lufei, Oguin, Thomas H., Miguez, Patricia A. et al. · 2020 · Cell Death & Differentiation
  99. The latest information on the RIPK1 post-translational modifications and functions
    Qiong Wang, Danping Fan, Ya Xia, Qinbin Ye, Xiaoyu Xi, Guoqiang Zhang, Cheng Xiao · 2021 · Biomedicine & Pharmacotherapy
  100. Ripks and Neuroinflammation
    Yue Xu, Feng Lin, Guolei Liao, Jiaxing Sun, Wenli Chen, Lei Zhang · 2024 · Molecular Neurobiology