RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong +13 more·2016·Science

DOI 10.1126/science.aaf6803

Cited by (611)

Items 201–300 of 611

Mechanisms of RIPK3‐induced inflammation
Inbar Shlomovitz, Sefi Zargrian, Motti Gerlic · 2016 · Immunology and Cell Biology
A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats
Monika Řehořová, Ingrid Vargová, Serhiy Forostyak, Irena Vacková, Karolína Turnovcová, Helena Kupcová Skalníková, Petr Vodička, Šárka Kubinová, Eva Syková, Pavla Jendelová · 2019 · Stem Cells Translational Medicine
Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases
Narjes Shahsavani, Hardeep Kataria, Soheila Karimi‐Abdolrezaee · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The clinical relevance of necroinflammation—highlighting the importance of acute kidney injury and the adrenal glands
Wulf Tonnus, Florian Gembardt, Markus Latk, Simon Paul Parmentier, Christian Hugo, Stefan Richard Bornstein, Andreas Linkermann · 2018 · Cell Death and Differentiation
Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)
Naoki Suzuki, Tetsuya Akiyama, Hitoshi Warita, Masashi Aoki · 2020 · Frontiers in Neuroscience
Modelling amyotrophic lateral sclerosis in rodents
Tiffany W. Todd, Leonard Petrucelli · 2022 · Nature reviews. Neuroscience
Inflammasomes in neurodegenerative diseases
Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Nai‐Hong Chen, Jiaqing Yan · 2024 · Translational Neurodegeneration
Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis
Sebastiano Giuseppe Crisafulli, Simona Brajkovic, Maria Sara Cipolat Mis, Valeria Parente, Stefania Paola Corti · 2017 · Molecular Neurobiology
Circulating biomarkers of cell death
Kerstin Wimmer, Monika Sachet, Rudolf Oehler · 2019 · Clinica Chimica Acta
RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization
Takashi Ueta, Kenji Ishihara, Shoji Notomi, Jong‐Jer Lee, Daniel Enrique Maidana, Nikolaos E. Efstathiou, Yusuke Murakami, Eiichi Hasegawa, Kunihiro Azuma, Tetsuya Toyono et al. · 2019 · Proceedings of the National Academy of Sciences
The Molecular Mechanism of Retina Light Injury Focusing on Damage from Short Wavelength Light
Bin Fan, Chun-Xia Zhang, Jing Chi, Yang Liang, Xiao-Li Bao, Yun-Yi Cong, Bo Yu, Xun Li, Guangyu Li · 2022 · Oxidative Medicine and Cellular Longevity
Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders
Olayemi Kafilat Ijomone, Ukwubile Ileje Inelo, Vivian O. Aneke, Tobiloba Samuel Olajide, Happiness Ochi Inyang, Omolabake I. Omotosho, Toheeb Olalekan Oyerinde, Victor Ebube Anadu, Tolulope Judah Gbayisomore, Oritoke Modupe Okeowo et al. · 2025 · Neuroglia
MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice
Peiyu Bian, Xuyang Zheng, Li Wei, Chuantao Ye, Hong Fan, Yanhui Cai, Ying Zhang, Fanglin Zhang, Zhansheng Jia, Yingfeng Lei · 2017 · Frontiers in Microbiology
Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury
Fang Han, Xiao-Ming Guan, Wei Guo, Bai Lu · 2019 · Neurobiology of Disease
Mechanisms of neuronal survival safeguarded by endocytosis and autophagy
Melina Overhoff, Elodie De Bruyckere, Natalia L. Kononenko · 2020 · Journal of Neurochemistry
miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease
Sara R. Oliveira, Pedro A. Dionísio, Maria Manuela Gaspar, Leonor Correia Guedes, Miguel M Coelho, Mário Miguel Rosa, Joaquim José Ferreira, Joana D. Amaral, Cecília M. P. Rodrigues · 2021 · Frontiers in Cell and Developmental Biology · Retracted
Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures
Ana Águeda-Pinto, Luís Q. Alves, Fabiana Neves, Grant McFadden, Bertram L. Jacobs, L. Filipe C. Castro, Masmudur M. Rahman, Pedro José Esteves · 2021 · Frontiers in Immunology
The Impact of Kinases in Amyotrophic Lateral Sclerosis at the Neuromuscular Synapse: Insights into BDNF/TrkB and PKC Signaling
Maria Angel Lanuza, Laia Just‐Borràs, Erica Hurtado, Víctor Cilleros‐Mañé, Marta Tomàs, Neus García, Josep Maria Tomàs · 2019 · Cells
Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation
Sushanth Kumar, Sakar Budhathoki, Christopher B. Oliveira, August D. Kahle, O. Yipkin Calhan, John R. Lukens, Christopher D. Deppmann · 2023 · JCI Insight
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
Tian Zhang, Weixin Fu, Haosong Zhang, Jianlong Li, Beizi Xing, Yuping A. Cai, Mengmeng Zhang, Xuheng Liu, Chunting Qi, Lihui Qian et al. · 2024 · Nature Cell Biology
MicroRNA‐183‐5p is stress‐inducible and protects neurons against cell death in amyotrophic lateral sclerosis
Chunyu Li, Yongping Chen, Xueping Chen, Qianqian Wei, Ruwei Ou, Xiaojing Gu, Bei Cao, Huifang Shang · 2020 · Journal of Cellular and Molecular Medicine
Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells
Hanqing He, Yuqian Wang, Xiaoting Zhang, Xiaoyu Li, Chao Liu, Dingfei Yan, Haiteng Deng, Wanling Sun, Chengqi Yi, Jianwei Wang · 2024 · Nature Aging
Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis
Matija Zelic, Anna S. Blazier, Fabrizio Pontarelli, Michael J. LaMorte, Jeremy Huang, Ozge E. Tasdemir-Yilmaz, Yi Ren, Sean K. Ryan, Cynthia Shapiro, Caroline Morel et al. · 2025 · Immunity
VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
Hiroto Takeuchi, Satoshi Inagaki, Wataru Morozumi, Yukimichi Nakano, Yuki Inoue, Yoshiki Kuse, Takahiro Mizoguchi, Shinsuke Nakamura, Michinori Funato, Hideo Kaneko et al. · 2018 · Scientific Reports
Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Koy Chong Ng Kee Kwong, Arpan R. Mehta, Maiken Nedergaard, Siddharthan Chandran · 2020 · Acta Neuropathologica Communications
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS
Sara L. Domínguez, Eugene E. Varfolomeev, Robert P. Brendza, Kim Stark, Joy S. Tea, Jose Imperio, Hai Ngu, Timothy Earr, Oded Foreman, Joshua D. Webster et al. · 2020 · Cell Death and Differentiation
RIPK1 inhibitor ameliorates the MPP+/MPTP-induced Parkinson’s disease through the ASK1/JNK signalling pathway
Jing Liu, Huizheng Hu, Binyan Wu · 2021 · Brain Research
Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice
Qi-Qi Liang, Zijian Shi, Tao Yuan, Siyuan Chen, Yaping Li, Hongrui Zhang, Yi-Ping You, Rong Xu, Lihui Xu, Bo Hu et al. · 2023 · International Immunopharmacology
Necroptosis is one of the modalities of cell death accompanying ischemic brain stroke: from pathogenesis to therapeutic possibilities
Valentina Hribljan, Damir Lisjak, Dražen Juraj Petrović, Dinko Mitrečić · 2019 · Croatian Medical Journal
Artesunate Combined With Metformin Ameliorate on Diabetes-Induced Xerostomia by Mitigating Superior Salivatory Nucleus and Salivary Glands Injury in Type 2 Diabetic Rats via the PI3K/AKT Pathway
Siqin Zhang, Jiarui Li, Xiaolin Nong, Yuxiang Zhan, Jiazhi Xu, Danni Zhao, Chubin Ma, Yuchen Wang, Yixing Li, Zhan Li et al. · 2021 · Frontiers in Pharmacology
An immunohistochemical atlas of necroptotic pathway expression
Shene Chiou, Aysha Al‐Ani, Yi Pan, Komal M. Patel, Isabella Y. Kong, Lachlan W. Whitehead, Amanda Light, Samuel N. Young, Marilou H. Barrios, Callum J. Sargeant et al. · 2024 · EMBO Molecular Medicine
A Glimpse of necroptosis and diseases
Ming Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang · 2022 · Biomedicine & Pharmacotherapy
RIPK1 in necroptosis and recent progress in related pharmaceutics
Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang et al. · 2025 · Frontiers in Immunology
Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations
Takashi Ayaki, Hidefumi Ito, Osamu Komure, Masaki Kamada, Masataka Nakamura, Reika Wate, Hirofumi Kusaka, Yuko Yamaguchi, Fangzhou Li, Hideshi Kawakami et al. · 2017 · Journal of Neuropathology & Experimental Neurology
RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39°C
Jie Yan, Kun Xiong, Limin Guo, Zhen Wang, Shiping Li, Mi Wang, Weitao Yan, Fengxia Liu, Chudong Wang, Xu-Dong Zhang et al. · 2019 · Neural Regeneration Research
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury
Sara Salvany, Anna Casanovas, Lídia Piedrafita, Olga Tarabal, Sara Hernández, Jordi Calderó, Josep Enric Esquerda · 2021 · Glia
Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis
Élisabeth Traiffort, Séverine Morisset‐Lopez, Mireille Moussaed, Amina Zahaf · 2021 · International Journal of Molecular Sciences
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner
MacLean, Michael, Juranek, Judyta, Cuddapah, Swetha, López-Díez, Raquel, Ruiz, Henry H., Hu, Jiyuan, Frye, Laura, Li, Huilin, Gugger, Paul F., Schmidt, Ann Marie · 2021 · Journal of Neuroinflammation
A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population
Binbin Wang, Suying Bao, Zhigang Zhang, Xueya Zhou, Jing Wang, Yanhui Fan, Yan Zhang, Yan Li, Luhua Chen, Yizhen Jia et al. · 2018 · Neurobiology of Aging
Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment
Janos Groh, Rudolf Martini · 2017 · Glia
Moringin Pretreatment Inhibits the Expression of Genes Involved in Mitophagy in the Stem Cell of the Human Periodontal Ligament
Luigi Chiricosta, Agnese Gugliandolo, Francesca Diomede, Jacopo Pizzicannella, Oriana Trubiani, Renato Iori, Giuseppe Tardiolo, Simone Guarnieri, Placido Bramanti, Emanuela Mazzon · 2019 · Molecules
Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner
Weizhe Zhong, Xiaowei Wang, Zhuqing Rao, Xiongxiong Pan, Yu Sun, Tao Jiang, Ping Wang, Haoming Zhou, Xuehao Wang · 2020 · Annals of Translational Medicine
Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases
Evelien Van Schoor, Marta J. Koper, Simona Ospitalieri, Lieselot Dedeene, Sandra O. Tomé, Rik R. Vandenberghe, Dávid Brenner, Markus Otto, Jochen Hans Weishaupt, Albert Christian Ludolph et al. · 2020 · Neuropathology and Applied Neurobiology
Ganetespib (STA-9090) augments sorafenib efficacy via necroptosis induction in hepatocellular carcinoma: Implications from preclinical data for a novel therapeutic approach
Sameh Saber, Alexandru Madalin Hasan, Osama A. Mohammed, Lobna A. Saleh, Abdullah A. Hashish, Mohannad Mohammad S. Alamri, Ahmed Y. Al-Ameer, Jaber Ahmed Alfaifi, Ahmed Mussad Senbel, Adel Mohamed Aboregela et al. · 2023 · Biomedicine & Pharmacotherapy
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration
Liu, Dong, Webber, Hannah C., Bian, Fuyun, Xu, Yangfan, Prakash, Manjari, Feng, Xue, Yang, Ming, Yang, Hang, You, In-Jee, Li, Liang et al. · 2025 · Nature Communications
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice
Xiaoling Zhou, Juan Yang, Xian‐Jun Qu, Jianping Meng, Rongrong Miao, Shu‐Xiang Cui · 2020 · Frontiers in Pharmacology
An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions
Marie Oliver Metzig, Ying Tang, Simon A. Mitchell, Brooks E. Taylor, Robert Foreman, Roy Wollman, Alexander Hoffmann · 2020 · Molecular Systems Biology
Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy
Jiahao Bao, Yixuan Yan, Daihui Zuo, Zhiyong Zhuo, Tianhao Sun, Hongli Lin, Zheshen Han, Zhiyang Zhao, Hongbo Yu · 2023 · Frontiers in Nutrition
Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization
Xin Liu, Miao Tang, Tian-Yi He, Shuang Zhao, Hui-Zhou Li, Li Zhao, Yuexian Guo, Xiu-Li Wang · 2023 · Drug Design Development and Therapy
Targeting Necroptosis as a Promising Therapy for Alzheimer’s Disease
Wenli Zhao, Yue Liu, Lijuan Xu, Yuan He, Zhenyu Cai, Jianqiang Yu, Wannian Zhang, Chengguo Xing, Chunlin Zhuang, Zhuo Qu · 2022 · ACS Chemical Neuroscience
Necroptosis in CNS diseases: Focus on astrocytes
Еlena V. Mitroshina, Mariia O. Saviuk, Maria V. Vedunova · 2023 · Frontiers in Aging Neuroscience
Micro RNA s as regulators of cell death mechanisms in amyotrophic lateral sclerosis
Delia Gagliardi, Giacomo P. Comi, Nereo Bresolin, Stefania Paola Corti · 2019 · Journal of Cellular and Molecular Medicine
Microglial Dysfunction in Neurodegenerative Diseases via RIPK1 and ROS
Qiaoyan Wu, Chengyu Zou · 2022 · Antioxidants
Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice
Jeremy M. Sullivan, Anna M. Bagnell, Jonathan Alevy, Elvia Mena Avila, Ljubica Mihaljević, Pamela C. Saavedra-Rivera, Lingling Kong, Jennifer S. Huh, Brett A. McCray, William H. Aisenberg et al. · 2024 · Science Translational Medicine
The Contribution of Necroptosis in Neurodegenerative Diseases
Lifei Shao, Shuping Yu, Wei Ji, Haizhen Li, Yilu Gao · 2017 · Neurochemical Research
Novel key genes in triple‐negative breast cancer identified by weighted gene co‐expression network analysis
Jian Chen, Xiaojun Qian, Yifu He, Xinghua Han, Yueyin Pan · 2019 · Journal of Cellular Biochemistry
RIP3 inhibition protects locomotion function through ameliorating mitochondrial antioxidative capacity after spinal cord injury
Yang Wang, Jianhang Jiao, Shanyong Zhang, Changjun Zheng, Minfei Wu · 2019 · Biomedicine & Pharmacotherapy
New insights on the disease contribution of neuroinflammation in amyotrophic lateral sclerosis
Aude Chiot, Christian S. Lobsiger, Séverine Boillée · 2019 · Current Opinion in Neurology
Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography
Yu Lan, Ping Bai, Yan Liu, Sepideh Afshar, Robin Striar, A Rattray, Tyler Nicholas Meyer, Amelia G. Langan, Alisa M. Posner, Shiqian Shen et al. · 2021 · Journal of Medicinal Chemistry
A Prospective Viewpoint on Neurological Diseases and Their Biomarkers
Mehrukh Zehravi, Janisa Kabir, Rokeya Akter, Sumira Malik, Ghulam Md Ashraf, Priti Tagde, Sarker Ramproshad, Banani Mondal, Md. Habibur Rahman, Aurel George Mohan et al. · 2022 · Molecules
Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling
Nydia P. Chang, Evan M. DaPrano, Marissa Lindman, Irving Estevez, Tsui-Wen Chou, Wesley R. Evans, Marialaina Nissenbaum, Micheal McCourt, Diego Alzate, Colm Atkins et al. · 2024 · JCI Insight
Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions
Jingchun Du, Zhigao Wang · 2024 · Biomedicines
RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis
Nao Saito, Masaru Honma, Takashi Shibuya, Shin Iinuma, Satomi Igawa, Mari Kishibe, Akemi Ishida‐Yamamoto · 2018 · Journal of Dermatological Science
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency
Søren Lejsted Faergeman, Hayley G. Evans, Kathrine E. Attfield, Christiane Desel, Subita Balaram Kuttikkatte, Mette Sommerlund, Lise Torp Jensen, Jørgen Frøkiær, Manuel Alexander Friese, Paul McMahan Matthews et al. · 2020 · Cell Death and Disease
Discovery of a cooperative mode of inhibiting RIPK1 kinase
Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu et al. · 2021 · Cell Discovery
Friend or foe: role of pathological tau in neuronal death
Moxin Wu, Zhiying Chen, Min Hua Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling‐Qiang Zhu · 2023 · Molecular Psychiatry
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation
Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Felipe Véliz‐Valverde, Somya Iqbal, Samantha L. Eaton, Rachel Kline, Douglas J. Lamont, Hernán Huerta, Gonzalo Ureta et al. · 2023 · Aging Cell
Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS
Elisabetta Carata, Marco Muci, Simona Di Giulio, Stefania Mariano, Elisa Panzarini · 2023 · International Journal of Molecular Sciences
Amyotrophic lateral sclerosis
David S. Younger, Robert H. Brown · 2023 · Handbook of clinical neurology
Optineurin Functions for Optimal Immunity
Karolina Slowicka, Geert Loo · 2018 · Frontiers in Immunology
Apelin attenuates streptozotocin-induced learning and memory impairment by modulating necroptosis signaling pathway
Behzad Nasseri, Parvin Zareian, Hadi Alizade · 2020 · International Immunopharmacology
Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature
Maria Regoni, Flavia Valtorta, Jenny Sassone · 2023 · European Journal of Neuroscience
Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis
Kiterie M. E. Faller, Helena Chaytow, Thomas Henry Gillingwater · 2025 · Nature Reviews Neurology
Molecular mechanism of PANoptosis and programmed cell death in neurological diseases
Ketian Hou, Wenhan Pan, L.-Y. Liu, Qianqian Yu, J T Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang · 2025 · Neurobiology of Disease
T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death
Nicholas H. Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin, Julian K. Horwitz, Jesse D. Gelles, Jerry E. Chipuk, Michelle A. Kelliher, Vasile I. Pavlov et al. · 2021 · JCI Insight
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization
Qi Zhang, Yanan Li, Yanqin Liu, Xin Wang, Yonghui Yang, Lei Shi · 2024 · Cellular Signalling
Optineurin defects cause TDP43-pathology with autophagic vacuolar formation
Takashi Kurashige, Masahito Kuramochi, Ryosuke Ohsawa, Yui Yamashita, Go Shioi, Hiroyuki Morino, Masaki Kamada, Takashi Ayaki, Hidefumi Ito, Yusuke Sotomaru et al. · 2020 · Neurobiology of Disease
The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease
Emma C. Tovey Crutchfield, Sarah E. Garnish, Joanne M. Hildebrand · 2021 · Biomolecules
Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis
Sara Salvany, Anna Casanovas, Lídia Piedrafita, Sílvia Gras, Jordi Calderó, Josep Enric Esquerda · 2022 · Brain Pathology
Necroptosis and Neuroinflammation in Retinal Degeneration
Yan Tao, Yusuke Murakami, Demetrios G. Vavvas, Koh‐Hei Sonoda · 2022 · Frontiers in Neuroscience
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis
Hongyan Guo, Heather S. Koehler, Edward S. Mocarski, Richard D. Dix · 2022 · PLoS Pathogens
Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis
Stefan Bräuer, Vitaly L. Zimyanin, Andreas Hermann · 2018 · Journal of Neural Transmission
Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench
Franz, Colin K., Joshi, Divya, Daley, Elizabeth L., Grant, Rogan A., Dalamagkas, Kyriakos, Leung, Audrey, Finan, John D., Kiskinis, Evangelos · 2019 · Journal of Neurophysiology
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease
Sing‐Wai Wong, Bowen Huang, Xiangxiang Hu, Eui Ho Kim, Joseph P. Kolb, Ricardo J. Padilla, Peng Xue, Lufei Wang, Thomas H. Oguin, Patrícia A. Miguez et al. · 2020 · Cell Death and Differentiation
Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral Sclerosis
Shumin Zhao, Ranran Chen, Ying Gao, Yanchao Lu, Xue Bai, Jingjing Zhang · 2023 · Frontiers in Neuroscience
Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration
Brian Fiani, Athanasios Kondilis, Marisol Soula, Anthony Y. Tao, Mohammed Ali Alvi · 2021 · Neurospine
Dysmyelination by Oligodendrocyte‐Specific Ablation of Ninj2 Contributes to Depressive‐Like Behaviors
Yuxia Sun, Xiang Chen, Zhimin Ou, Yue Wang, Wenjing Chen, Tong‐Jin Zhao, Changqin Liu, Ying Chen · 2021 · Advanced Science
Update of cellular responses to the efferocytosis of necroptosis and pyroptosis
Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana, Keri Lestari · 2023 · Cell Division
A Role for Receptor-Interacting Protein Kinase-1 in Neutrophil Extracellular Trap Formation in Patients with Systemic Lupus Erythematosus: a Preliminary Study
Ruru Guo, Yang Tu, Shaowei Xie, Xue song Liu, Song Yang, Suli Wang, Xiaoxiang Chen, Liangjing Lu · 2018 · Cellular Physiology and Biochemistry
Jia-Ji Electro-Acupuncture Improves Locomotor Function With Spinal Cord Injury by Regulation of Autophagy Flux and Inhibition of Necroptosis
Hongna Yin, Tian Hongzhao, Quan Li, Feng Delin, Liu Guijun, Xiaolin Lv, Guan Fulin, Sun Zhongren · 2021 · Frontiers in Neuroscience
C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
Sivakami Mylvaganam, Rebecca Earnshaw, Gregory Heymann, Suneil Kumar Kalia, Lorraine V. Kalia · 2020 · Current Neuropharmacology
RIP1-Mediated Necroptosis Facilitates Oxidative Stress‒Induced Melanocyte Death, Offering Insight into Vitiligo
Bowei Li, Xiuli Yi, Tongtian Zhuang, Shaolong Zhang, Shuli Li, Yuqi Yang, Tingting Cui, Jiaxi Chen, Yuqian Chang, Tianwen Gao et al. · 2021 · Journal of Investigative Dermatology
RIP kinases and necroptosis in aging and aging-related diseases
Yuanxin Yang, Xingyan Li, Tao Zhang, Daichao Xu · 2022 · Life Medicine
Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases
Rohan V. Gupta, Smita Kumari, Rahul S. Tripathi, Rashmi K. Ambasta, Pravir Kumar · 2023 · Ageing Research Reviews
A phase I randomized, double‐blinded , placebo‐controlled study assessing the safety and pharmacokinetics of RIPK1 inhibitor GFH312 in healthy subjects
Jason D. Lickliter, Shuang Wang, Wenxin Zhang, Huaqiang Zhu, Jing Wang, Congqiao Zhao, Haige Shen, Yu Wang · 2023 · Clinical and Translational Science
Proteomics and Toxicity Analysis of Spinal-Cord Primary Cultures upon Hydrogen Sulfide Treatment
Viviana Greco, Alida Spalloni, Victor Corasolla Carregari, Luisa Pieroni, Silvia Persichilli, Nicola Biagio Mercuri, Andrea Urbani, Patrizia Longone · 2018 · Antioxidants
Retinal Ganglion Cells Die by Necroptotic Mechanisms in a Site-Specific Manner in a Rat Blunt Ocular Injury Model
Chloe N. Thomas, Adam M. Thompson, Zubair Ahmed, Richard James Blanch · 2019 · Cells
Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage
Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhang · 2024 · Experimental Neurology
Small molecule probes for cellular death machines
Ying Li, Lihui Qian, Junying Yuan · 2017 · Current Opinion in Chemical Biology
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury
Yuan Zhuang, Haifeng C. Xu, Prashant V. Shinde, Jens Warfsmann, Jeļena Vasiļevska, Balamurugan Sundaram, Kristina Behnke, Jun Huang, Jessica I. Hoell, Arndt Borkhardt et al. · 2019 · Gut