The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Spatiotemporal microbial evolution on antibiotic landscapes
Open accessAbstract
A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying environmental challenges. Laboratory experiments, however, often study evolution in well-mixed systems. Here, we introduce an experimental device, the microbial evolution and growth arena (MEGA)–plate, in which bacteria spread and evolved on a large antibiotic landscape (120 × 60 centimeters) that allowed visual observation of mutation and selection in a migrating bacterial front. While resistance increased consistently, multiple coexisting lineages diversified both phenotypically and genotypically. Analyzing mutants at and behind the propagating front, we found that evolution is not always led by the most resistant mutants; highly resistant mutants may be trapped behind more sensitive lineages. The MEGA-plate provides a versatile platform for studying microbial adaption and directly visualizing evolutionary dynamics.
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Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
Rasche, L., Chavan, S. S., Stephens, O. W., Patel, P. H., Tytarenko, R., Ashby, C., Bauer, M., Stein, C., Deshpande, S., Wardell, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00296-y · Cited by 417
Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance
Zheng, M., Zhang, R., Tian, X., Zhou, X., Pan, X., & Wong, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00908 · Cited by 218
Rocca, J. D., Simonin, M., Blaszczak, J. R., Ernakovich, J. G., Gibbons, S. M., Midani, F. S., & Washburne, A. D. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03272 · Cited by 213
Estimating the genome-wide contribution of selection to temporal allele frequency change
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Metadata
- Authors
- Baym, M., Lieberman, T. D., Kelsic, E. D., Chait, R., Gross, R., Yelin, I., & Kishony, R.
- Venue
- Science
- Published
- 2016-09-09
- Volume
- 353
- Issue
- 6304
- Pages
- 1147-1151
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2511099695
- Cited by
- 538
- References
- 41
- FWCI
- 39.14
- Type
- journal article
- Language
- en
- Open access
- green
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