GenBank
Open accessAbstract
GenBank® (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assigns accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI home page: www.ncbi.nlm.nih.gov.
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For certain types of important digital objects, there are well-curated, deeply-integrated, special-purpose repositories such as Genbank, wwPDB, UniProt, SPDF, and SIMBAD.
“For certain types of important digital objects, there are well-curated, deeply-integrated, special-purpose repositories such as Genbank3, Worldwide Protein Data Bank (wwPDB4), and UniProt5 in the life sciences; Space Physics Data Facility (SPDF; http://spdf.gsfc.nasa.gov/) and Set of Identifications, Measurements and Bibliography for Astronomical Data (SIMBAD6) in the space sciences.”
From The FAIR Guiding Principles for scientific data management and stewardship (2016) · cites this paper as [3]
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- Authors
- Benson, D. A., Cavanaugh, M., Clark, K., Karsch-Mizrachi, I., Lipman, D. J., Ostell, J., & Sayers, E. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Sayers, Eric W.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-11-26
- Volume
- 41
- Issue
- D1
- Pages
- D36-D42
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC3531190
- OpenAlex
- W4242729757
- Cited by
- 3,261
- References
- 3
- Citations by year
- 2026: 202 · 2025: 294 · 2024: 321 · 2023: 263 · 2022: 277 · 2021: 281 · 2020: 250 · 2019: 228 · 2018: 238 · 2017: 235 · 2016: 218 · 2015: 190 · 2014: 174 · 2013: 81 · 2012: 6
- FWCI
- 58.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. National Library of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genetics, Bioinformatics, and Biomedical Research
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- GenBank, DNA sequence databases, sequence submission, accession numbers, whole genome shotgun sequencing, European Nucleotide Archive, DDBJ, BLAST, sequence similarity search
- MeSH terms
- Base Sequence, Sequence Analysis, DNA, Internet, Genomics, Databases, Nucleic Acid, Molecular Sequence Annotation, High-Throughput Nucleotide Sequencing
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