The resurgence of NAD +

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711 · see citing works

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042357 · Cited by 545 · see citing works

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works

Biosensor reveals multiple sources for mitochondrial NAD ⁺

Cambronne, X. A., Stewart, M. L., Kim, D., Jones-Brunette, A. M., Morgan, R. K., Farrens, D. L., Cohen, M. S., & Goodman, R. H. (2016) · Science · doi:10.1126/science.aad5168 · Cited by 407 · see citing works

Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00355.x · Cited by 321 · see citing works

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

Chalkiadaki, A., Igarashi, M., Nasamu, A. S., Knezevic, J., & Guarente, L. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004490 · Cited by 126 · see citing works

NAD ⁺ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.016 · Cited by 384 · see citing works

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells

Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 90 · see citing works

Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice

Li, X., Wang, X., Zhang, C., Wang, J., Wang, S., & Hu, L. (2022) · Cell Proliferation · doi:10.1111/cpr.13191 · Cited by 76 · see citing works

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

Ward, J. M., Stoyas, C. A., Switonski, P. M., Ichou, F., Fan, W., Collins, B. L., Wall, C. E., Adanyeguh, I. M., Niu, C., Sopher, B. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.028 · Cited by 73 · see citing works

Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae

Guaragnella, N., Coyne, L. P., Chen, X. J., & Giannattasio, S. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy088 · Cited by 72 · see citing works

NAD(H) in mitochondrial energy transduction: implications for health and disease

Walker, M. A., & Tian, R. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.03.011 · Cited by 58 · see citing works

Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

Yen, C., Ruter, D. L., Turner, C. D., Pang, S., & Curran, S. P. (2020) · eLife · doi:10.7554/elife.52899 · Cited by 42 · see citing works

Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics

Williams, A. C., & Hill, L. J. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917704661 · Cited by 39 · see citing works

Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation

Jhanji, M., Rao, C. N., & Sajish, M. (2020) · GeroScience · doi:10.1007/s11357-020-00295-w · Cited by 36 · see citing works

Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology

Nesci, S., Trombetti, F., & Pagliarani, A. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.11.001 · Cited by 35 · see citing works

Exogenous NAD+ Postpones the D-Gal-Induced Senescence of Bone Marrow-Derived Mesenchymal Stem Cells via Sirt1 Signaling

Wang, J., Liu, L., Ding, Z. J., Luo, Q., Ju, Y., & Song, G. (2021) · Antioxidants · doi:10.3390/antiox10020254 · Cited by 34 · see citing works

Fermi-level pinning appears upon weak electrode-organic contact without gap states: A universal phenomenon

Yang, J., Shang, L.-T., Bussolotti, F., Cheng, L., Wang, W., Zeng, X., Kera, S., Li, Y., Tang, J., & Ueno, N. (2017) · Organic Electronics · doi:10.1016/j.orgel.2017.06.005 · Cited by 29 · see citing works

NAD metabolism in aging and cancer

Kincaid, J. W. R., & Berger, N. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220929287 · Cited by 28 · see citing works

Meat Intake and the Dose of Vitamin B 3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

Hill, L. J., & Williams, A. C. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917704662 · Cited by 23 · see citing works

Characteristics of Ultrasound-Driven Barium Titanate Nanoparticles and the Mechanism of Action on Solid Tumors

Li, S., He, N., Wu, X., Chen, F., Xue, Q., Li, S., & Zhao, C. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s491816 · Cited by 22 · see citing works

Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice

Tozzi, R., Campolo, F., Baldini, E., Venneri, M. A., Lubrano, C., Ulisse, S., Gnessi, L., & Mariani, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415860 · Cited by 15 · see citing works

In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging

Zhu, X.-H., & Chen, W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00394 · Cited by 15 · see citing works

NAD + Levels Are Augmented in Aortic Tissue of ApoE −/− Mice by Dietary Omega-3 Fatty Acids

Chi, D. H., Kahyo, T., Islam, A., Hasan, M. M., Waliullah, A. S. M., Mamun, M. A., Nakajima, M., Ikoma, T., Akita, K., Maekawa, Y., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317166 · Cited by 11 · see citing works

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease

Cronise, R. J., Sinclair, D. A., & Bremer, A. A. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0108 · Cited by 10 · see citing works

Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

Haubrich, B. A., Ramesha, C. S., & Swinney, D. C. (2019) · SLAS DISCOVERY · doi:10.1177/2472555219879644 · Cited by 10 · see citing works

NAD+-Consuming Enzymes in Stem Cell Homeostasis

Ji, X., Zheng, M., Yu, T., Kang, J., Fan, T., & Xu, B. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/4985726 · Cited by 7 · see citing works

Age-related schwannomatosis with potential exosome-mediated contribution to prostate hyperplasia: a case report and mini-review

Chignon‐Sicard, B., Hofman, V., Chevallier, D., Cucchi, J. M., Ilié, M., Dadone‐Montaudié, B., Paul, F., Carpentier, X., Quintens, H., Bence-Gauchiez, C., et al. (2019) · Therapeutic Advances in Urology · doi:10.1177/1756287219875578 · Cited by 6 · see citing works

The inhibition of the mitochondrial F 1 F O -ATPase activity when activated by Ca 2+ opens new regulatory roles for NAD +

Nesci, S., Trombetti, F., Ventrella, V., Pirini, M., & Pagliarani, A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0209 · Cited by 4 · see citing works

Relief for retinal neurons under pressure

Crowston, J. G., & Trounce, I. A. (2017) · Science · doi:10.1126/science.aam7935 · Cited by 2 · see citing works

Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegansPreprint

Yen, C.-A., Ruter, D. L., Turner, C. D., Pang, S., & Curran, S. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/456863 · Cited by 2 · see citing works

Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in Response to Energetic Stress in Human Skeletal Muscle

Edgett, B. A. (2017) · QSpace (Queen's University Library)

Nature Versus Nurture: What Can be Learned from the Oldest-Old's Claims About Longevity?

Poljšak, B., Kovač, V., Levec, T., & Milisav, I. (2021) · Rejuvenation Research · doi:10.1089/rej.2020.2379

Immunohistochemical Analysis of Nicotinamide Phosphoribosyltransferase Expression in Gastric and Esophageal Adenocarcinoma (AEG)

Arnold, A., von Winterfeld, M., Berg, E. G., Hummel, M., Rau, B., Krenzien, F., Stein, U., & Treese, C. (2022) · Gastrointestinal Disorders · doi:10.3390/gidisord4040031

Atomic Ce sites promote a four-electron pathway of Pt as NADH oxidase mimics for in situ coenzyme regeneration

Tang, Y., Chen, Y., Qi, P., Li, R., Jiang, W., Sun, H., Gu, W., & Zhu, C. (2026) · Chemical Science · doi:10.1039/d6sc00612d

Restoring stem cells — all you need is NAD+

Wu, L. E., & Sinclair, D. A. (2016) · Cell Research · doi:10.1038/cr.2016.80 · Cited by 19 · see citing works

Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

Son, M. J., Kwon, Y., Son, T., & Cho, Y. S. (2016) · Stem Cells · doi:10.1002/stem.2460 · Cited by 85 · see citing works

The role of NAD+ metabolism and its modulation of mitochondria in aging and disease

Yusri, K., Jose, S., Vermeulen, K. S., Tan, T. C. M., & Sorrentino, V. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00067-0 · Cited by 171 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

Yuan, X., Liu, Y., Bijonowski, B. M., Tsai, A., Fu, Q., Logan, T. M., Ma, T., & Li, Y. (2020) · Communications Biology · doi:10.1038/s42003-020-01514-y · Cited by 88 · see citing works