The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability
Open accessAbstract
How proteomes take the heat: Living organisms are very sensitive to temperature, and much of this is attributed to its effect on the structure and function of proteins. Leuenberger et al. explored thermostability on a proteome-wide scale in bacteria, yeast, and human cells by using a combination of limited proteolysis and mass spectrometry (see the Perspective by Vogel). Their results suggest that temperature-induced cell death is caused by the loss of a subset of proteins with key functions. The study also provides insight into the molecular and evolutionary bases of protein and proteome stability. Science , this issue p. eaai7825 ; see also p. 794
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Cites
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Global analysis of protein folding using massively parallel design, synthesis, and testing
Rocklin, G. J., Chidyausiku, T. M., Goreshnik, I., Ford, A., Houliston, S., Lemak, A., Carter, L., Ravichandran, R., Mulligan, V. K., Chevalier, A., et al. (2017) · Science · doi:10.1126/science.aan0693 · Cited by 501
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Stoeger, T., Gerlach, M., Morimoto, R. I., & Nunes Amaral, L. A. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006643 · Cited by 261
Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution
Gaetani, M., Sabatier, P., Saei, A. A., Beusch, C. M., Yang, Z., Lundström, S. L., & Zubarev, R. A. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00500 · Cited by 287
Thermal proteome profiling for interrogating protein interactions
Mateus, A., Kurzawa, N., Becher, I., Sridharan, S., Helm, D., Stein, F., Typas, A., & Savitski, M. M. (2020) · Molecular Systems Biology · doi:10.15252/msb.20199232 · Cited by 258
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Guo, H.-B., Perminov, A., Bekele, S., Kedziora, G., Farajollahi, S., Varaljay, V., Hinkle, K., Molinero, V., Meister, K., Hung, C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14382-9 · Cited by 248
Metadata
- Authors
- Leuenberger, P., Ganscha, S., Kahraman, A., Cappelletti, V., Boersema, P. J., von Mering, C., Claassen, M., & Picotti, P.
- Venue
- Science
- Published
- 2017-02-24
- Volume
- 355
- Issue
- 6327
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2590059905
- Cited by
- 411
- References
- 7
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Leuenberger, P., Ganscha, S., Kahraman, A., Cappelletti, V., Boersema, P. J., von Mering, C., Claassen, M., & Picotti, P. (2017). Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability. Science. https://doi.org/10.1126/science.aai7825
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