Click chemistry enables preclinical evaluation of targeted epigenetic therapies

Cited by (152)

Items 101–152 of 152

1. Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
   Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah A. Jones, Eric Francis Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk et al. · 2020 · Cell Reports
2. Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers
   Andrew McGown, Vesna Vetma, Damien Crépin, Yan Lin, Claire Adcock, Conner Craigon, Jordan Nafie, Daniel von Emloh, Léa Sutton, Kiera Bailey et al. · 2025 · ACS Medicinal Chemistry Letters
3. Target engagement approaches for pharmacological evaluation in animal models
   James E. Kath, Aleksandra Baranczak · 2019 · Chemical Communications
4. Getting a Handle on Chemical Probes of Chomatin Readers
   Jarod M. Waybright, Lindsey Ingerman James · 2020 · Future Medicinal Chemistry
5. A curcumin derived probe for colorimetric detection of azide ions in water
   Susanta Sekhar Adhikari, Subhajit Guria, Avijit Ghosh, Abhishek Rudra Pal, Debasis Das · 2017 · New Journal of Chemistry
6. A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation
   Ha Phuong Nguyen, Sabrina K. Stewart, Mikiembo N. Kukwikila, Sioned Fôn Jones, Daniel Offenbartl‐Stiegert, Shi-Qing Mao, Shankar Balasubramanian, Stephan Beck, Stefan Howorka · 2019 · Angewandte Chemie
7. Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors
   Paul Bamborough, Chun‐wa Chung, Nicole C. Goodwin, Darren J. Mitchell, Christopher E. Neipp, Alex Phillipou, Alex G. S. Preston, Rab K. Prinjha, Peter E. Soden, Robert J. Watson et al. · 2023 · ACS Medicinal Chemistry Letters
8. Chemical Biology Tools for Protein Lysine Acylation
   Yusheng Xie, Shubo Du, Zhiyang Liu, Min Liu, Zhiqiang Xu, Xiaojie Wang, Jia Xuan Kee, Fan Yi, Hongyan Sun, Shao Qin Yao · 2022 · Angewandte Chemie
9. Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride)
   Daru Seto Bagus Anugrah, Maheshkumar Prakash Patil, Xinmeng Li, Cuong Minh Quoc Le, Kalyan Ramesh, G-D. Kim, Kyu Hyun, K. T. Lim · 2020 · eXPRESS Polymer Letters
10. Subcellular localization of drug distribution by super-resolution ion beam imaging
    Xavier Rovira‐Clavé, Sizun Jiang, Yunhao Bai, Graham L. Barlow, Salil S. Bhate, Ahmet F. Coskun, Guojun Han, Bokai Zhu, Chin‐Min Kimmy Ho, Chuck Hitzman et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
11. Single-cell multiomics: a new frontier in drug research and development
    Jian Ma, Chao Fang Dong, Aibin He, Haiqing Xiong · 2024 · Frontiers in Drug Discovery
12. Proteomics approaches in the identification of cancer biomarkers and drug discovery
    Nasir Nisar, Suhail Ahmad Mir, Ozaifa Kareem, Faheem Hyder Pottoo · 2023 · Elsevier eBooks
13. A Click Strategy for the Synthesis of Fluorescent Pyrimidinone‐Triazole Hybrids with CDK2 Selectivity in HeLa and A549 Cell Lines
    Aranhikkal Shamsiya, Damodaran Bahulayan · 2019 · ChemistrySelect
14. Macrocyclization in medicinal chemistry: updated strategies and applications
    Om Darlami, Keun-young Kim A, Dongyun Shin, Seok‐Ho Kim · 2025 · Medicinal Chemistry Research
15. Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells
    Christopher D. Sarsons, Dean Gilham, Laura M. Tsujikawa, Sylwia Wasiak, Li Fu, Brooke D. Rakai, Stephanie C. Stotz, Agostina Carestia, Michael Sweeney, Ewelina Kulikowski · 2023 · Biomedicines
16. Selectivity Mechanism of Pyrrolopyridone Analogues Targeting Bromodomain 2 of Bromodomain-Containing Protein 4 from Molecular Dynamics Simulations
    Mingsong Shi, Xueting Zheng, Yan Zhou, Yuan Yin, Lu Zhou, Zhiyan Zou, Yan Hu, Yuanyuan Liang, Tingting Chen, Yuhan Yang et al. · 2023 · ACS Omega
17. Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors
    Jiewei Jiang, Taimeng Liang, Jonathan C. Solberg, Alice Chan, Prakriti Kalra, Rui Shi, William C. K. Pomerantz, Jon E. Hawkinson, E. Schönbrunn, Gunda I. Georg · 2025 · European Journal of Medicinal Chemistry
18. Bioinspired Selenium‐Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole‐Scale Medicinal Chemistry and Bioconjugation
    Wei Hou, Yiyuan Zhang, Fuchao Huang, Wanting Chen, Yuang Gu, Yan Wang, Jiacheng Pang, Hewei Dong, Kangyin Pan, Shuning Zhang et al. · 2024 · Angewandte Chemie
19. Click and discover
    George S. Vassiliou, Shankar Balasubramanian · 2017 · Nature
20. Selective inhibition mechanism of three inhibitors to BRD4 uncovered by molecular docking and molecular dynamics simulations
    Wei Chen, L. Sang, R. Wang, D. Zou, Lin Chen · 2024 · SAR and QSAR in environmental research
21. Chromatin Regulatory Targets for Anticancer Therapeutics
    Paige A. Barta, Trever R. Carter, Michael A. Erb · 2025 · Chemical Reviews
22. Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor
    Laura V. de Paus, Yu An, Antonius P. A. Janssen, Richard J. B. H. N. van den Berg, Laura H. Heitman, Mario van der Stelt · 2024 · ChemBioChem
23. Reprogramming the chemical reactivity of iron in cancer stem cells
    Tatiana Cañeque, Sebastian Müller, Anne Lafon, Fabien Sindikubwabo, Antoine Versini, Lou Saier, Manon Barutaut, Christine Gaillet, Raphaël Rodriguez · 2018 · Comptes Rendus Chimie
24. Place Your BETs in Combination Therapy
    Brian Liddicoat, Mark A. Dawson · 2020 · Molecular Cell
25. Functional Proteomics
    Luke N. Erber, Yue Chen · 2021 · ACS in focus
26. Enzyme-free chemical DNA ligation via amine-crosslinker-mediated DNA assembly for miRNA detection
    Doyeon Lim, Zeeshan Haider, Hyo-Jin Lim, Won Jin Lee, Taeseok Kang, Hyuk Soo Eun, Jin Chul Kim, Youngjun Song · 2025 · Cell Reports Physical Science
27. Inert Complexes Unlock Ligand‐Accelerated Transition‐Metal Catalysis on Proteins
    Zhen Wang, Fengrui Xiang, XH Liao, Qingsong Wu, Jinbiao Jiao, Angzhi Bi, SiYang Maggie Liu, Dan Wang, Mengdi Wang, Zijian Guo et al. · 2026 · Angewandte Chemie International Edition
28. Supramolecular nanocatalyst in water: successive click-driven assembly of click-derived rod amphiphiles
    Inhye Kim, Eunji J. Lee · 2019 · Materials Chemistry Frontiers
29. The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461
    Madushani Amarasiri, Yen Vo, Michael G. Gardiner, Perlita Poh, Priscilla Soo, Megan Pavy, Nadine Hein, Rita Ferreira, Katherine M. Hannan, Ross D. Hannan et al. · 2021 · Australian Journal of Chemistry
30. Activatable fluorescence molecular imaging and anti-tumor effects investigation of GSH-sensitive BRD4 ligands
    Hang Zhang, Mingliang Zhang, Yujie Zhang, Han Wang, Linnan Zhao, Hai‐Wei Xu · 2022 · Bioorganic Chemistry
31. The Life Science Toolbox Provided by Chemical Biology
    Carsten Schultz · 2019 · Israel Journal of Chemistry
32. Selective N‐Terminal BET Bromodomain Inhibitors by Targeting Non‐Conserved Residues and Structured Water Displacement**
    Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, Huda Zahid, Zachariah J. Hoell, Mikael O. Ellingson, Ke Shi, Hideki Aihara, Daniel A. Harki et al. · 2020 · Angewandte Chemie
33. Design of BET Inhibitor Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities
    Farrukh Vohidov, Jannik N. Andersen, Kyriakos D. Economides, Michail V. Shipitsin, Olga V. Burenkova, James C. Ackley, Bhavatarini Vangamudi, Nolan M. Gallagher, Peyton Shieh, Matthew R. Golder et al. · 2020 · ChemRxiv
34. Single-cell profiling of small molecule-genomic interactions and epigenetic states
    Chao Dong, Xiaoxuan Meng, Tong Zhang, Zhifang Guo, Yaxi Liu, Peihuang Wu, Shiwei Chen, Fanqi Zhou, Yanni Ma, Shaokun Shu et al. · 2024 · Research Square
35. Association of MiR-29b/BRD4 with Airway Dysbiosis in Chronic Obstructive Pulmonary Disease after Smoking Cessation
    Siyi Zhou, Yu-xin Zeng, Tao Yu, Jianmiao Wang · 2025 · Current Medical Science
36. Additional file 1 of BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease
    Duan, Yifei, Zhou, Siyi, Wang, Jianmiao · 2023 · Figshare
37. Inert Complexes Unlock Ligand‐Accelerated Transition‐Metal Catalysis on Proteins
    Zhen Wang, Fengrui Xiang, XH Liao, Qingsong Wu, Jinbiao Jiao, Angzhi Bi, SiYang Maggie Liu, Dan Wang, Mengdi Wang, Zijian Guo et al. · 2026 · Angewandte Chemie
38. Des inhibiteurs de méthyltransférases de l'ADN au développement de sondes chimiques pour l'identification de modulateurs épigénétiques dérégulés dans les cancers
    Dany Pechalrieu · 2017 · theses.fr (ABES)
39. Validation de nouvelles cibles thérapeutiques dans le glioblastome par une approche de pharmacologie fonctionnelle
    Jérémy Ariey-Bonnet · 2020 · theses.fr (ABES)
40. Advancements in green click chemistry: Sustainable catalytic methods for the synthesis of 1,2,3-triazole derivatives
    Sahil Jindal, Rakesh Kumar, Chetan Sharma, Man Vir Singh, A Suresh Kumar, Yogesh Kumar · 2026 · Next research.
41. Reversible Click Reactions in Water: A Robust and Customizable Synthetic Tool
    Y.R. Shen, Yijian Zong, Huacheng Yu, Jiang‐Fei Xu, Mei‐Xiang Wang, Xi Zhang · 2026 · Angewandte Chemie International Edition
42. Reversible Click Reactions in Water: A Robust and Customizable Synthetic Tool
    Y.R. Shen, Yijian Zong, Huacheng Yu, Jiang‐Fei Xu, Mei‐Xiang Wang, Xi Zhang · 2026 · Angewandte Chemie
43. BindingDB Entry 50007698: Discovery of
    BindingDB · 2021 · UC San Diego
44. BindingDB Entry 50019895: Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases.
    BindingDB · 2024 · UC San Diego
45. BindingDB Entry 50011062: Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
    BindingDB · 2021 · UC San Diego
46. BindingDB Entry 50016263: Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development.
    BindingDB · 2023 · UC San Diego
47. BindingDB Entry 50010598: Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
    BindingDB · 2021 · UC San Diego
48. BindingDB Entry 50023478: PROTAC unleashed: Unveiling the synthetic approaches and potential therapeutic applications.
    BindingDB · 2026 · UC San Diego
49. BindingDB Entry 50022868: Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
    BindingDB · 2026 · UC San Diego
50. BindingDB Entry 50023737: Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors.
    BindingDB · 2026 · UC San Diego
51. BindingDB Entry 50016017: Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.
    BindingDB · 2023 · UC San Diego
52. BindingDB Entry 50018669: Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins.
    BindingDB · 2024 · UC San Diego