The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils
Open accessAbstract
A bona fide portrayal of tumor growth: Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom et al. show that bone may also contribute to early-stage tumorigenesis through a mechanism that leads to an increase in bone mass (see the Perspective by Zhang and Lyden). In mouse models of lung adenocarcinoma, primary tumor cells remotely activated bone-resident cells called osteoblasts, which have a bone-building function. The activated osteoblasts in turn triggered production of a certain type of neutrophil that infiltrates the primary tumor and promotes its growth. Patients with early-stage lung cancer were also found to have an increase in bone density, consistent with the findings in mice. Science , this issue p. eaal5081 ; see also p. 1127
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Metadata
- Authors
- Engblom, C., Pfirschke, C., Zilionis, R., Da Silva Martins, J., Bos, S. A., Courties, G., Rickelt, S., Severe, N., Baryawno, N., Faget, J., Savova, V., Zemmour, D., Kline, J., Siwicki, M., Garris, C., Pucci, F., Liao, H.-W., Lin, Y.-J., Newton, A., Yaghi, O. K., Iwamoto, Y., Tricot, B., Wojtkiewicz, G. R., Nahrendorf, M., Cortez-Retamozo, V., Meylan, E., Hynes, R. O., Demay, M., Klein, A., Bredella, M. A., Scadden, D. T., Weissleder, R., & Pittet, M. J.
- Venue
- Science
- Published
- 2017-12
- Volume
- 358
- Issue
- 6367
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2773700550
- Cited by
- 389
- References
- 82
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Engblom, C., Pfirschke, C., Zilionis, R., Da Silva Martins, J., Bos, S. A., Courties, G., Rickelt, S., Severe, N., Baryawno, N., Faget, J., Savova, V., Zemmour, D., Kline, J., Siwicki, M., Garris, C., Pucci, F., Liao, H.-W., Lin, Y.-J., Newton, A., . . . Pittet, M. J. (2017). Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils. Science. https://doi.org/10.1126/science.aal5081
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
