A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237 · see citing works

Hydrogels for biomedical applications

Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864 · see citing works

Hydrogels for biomedical applications

Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396 · see citing works

Generation of Functional Human Pancreatic β Cells In Vitro

Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025 · see citing works

International trial of the Edmonton protocol for islet transplantation

Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942 · see citing works

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575 · see citing works

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897 · see citing works

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Niu, D., Wei, H., Lin, L., George, H., Wang, T., Lee, I., Zhao, H., Wang, Y., Kan, Y., Shrock, E. L., et al. (2017) · Science · doi:10.1126/science.aan4187 · Cited by 765 · see citing works

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4030 · Cited by 710 · see citing works

Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia

Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645 · see citing works

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

Vegas, A. J., Veiseh, O., Doloff, J. C., Ma, M., Tam, H. H., Bratlie, K., Li, J., Bader, A. R., Langan, E., Olejnik, K., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3462 · Cited by 551 · see citing works

Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies.

Hentze, H., Soong, P., Wang, S. T., Phillips, B., Putti, T. C., & Dunn, N. R. (2009) · Stem Cell Research · doi:10.1016/j.scr.2009.02.002 · Cited by 474 · see citing works

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

Nair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0271-4 · Cited by 472 · see citing works

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

Garg, K., Pullen, N. A., Oskeritzian, C. A., Ryan, J. J., & Bowlin, G. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.065 · Cited by 457 · see citing works

Advances in islet encapsulation technologies

Desai, T., & Shea, L. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.232 · Cited by 427 · see citing works

Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site

Carlsson, P., Palm, F., Andersson, A., & Liss, P. (2001) · Diabetes · doi:10.2337/diabetes.50.3.489 · Cited by 416 · see citing works

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

Velazco-Cruz, L., Song, J., Maxwell, K. G., Goedegebuure, M. M., Augsornworawat, P., Hogrebe, N. J., & Millman, J. R. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.012 · Cited by 399 · see citing works

A prevascularized subcutaneous device-less site for islet and cellular transplantation

Pepper, A. R., Gala-Lopez, B., Pawlick, R., Merani, S., Kin, T., & Shapiro, A. M. J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3211 · Cited by 381 · see citing works

Generation of stem cell-derived β-cells from patients with type 1 diabetes

Millman, J., Xie, C.-H., VanDervort, A. V., Gürtler, M., Pagliuca, F., & Melton, D. (2016) · Nature Communications · doi:10.1038/ncomms11463 · Cited by 375 · see citing works

Insulin Secretion Depends on Intra-islet Glucagon Signaling

Svendsen, B., Larsen, O., Gabe, M. B. N., Christiansen, C. B., ROSENKILDE, M. M., Drucker, D. J., & Holst, J. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.018 · Cited by 356 · see citing works

An encapsulation system for the immunoisolation of pancreatic islets

Wang, T. G., Lacı́k, I., Briššová, M., Anilkumar, A. V., Prokop, A., Hunkeler, D. J., Green, R., Shahrokhi, K. A., & Powers, A. C. (1997) · Nature Biotechnology · doi:10.1038/nbt0497-358 · Cited by 318 · see citing works

Immunological and Technical Considerations in Application of Alginate-Based Microencapsulation Systems

Paredes-Juarez, G. A., Spasojević, M., Faas, M. M., & de Vos, P. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00026 · Cited by 284 · see citing works

Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo

Rezania, A., Bruin, J. E., Xu, J., Narayan, K., Fox, J., O'Neil, J., & Kieffer, T. (2013) · Stem Cells · doi:10.1002/stem.1489 · Cited by 269 · see citing works

Optimal implantation site for pancreatic islet transplantation

Merani, S., Toso, C., Emamaullee, J., & Shapiro, A. M. J. (2008) · British Journal of Surgery · doi:10.1002/bjs.6391 · Cited by 257 · see citing works

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Aguayo‐Mazzucato, C., & Bonner‐Weir, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.007 · Cited by 240 · see citing works

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Bruin, J. E., Rezania, A., Xu, J., Narayan, K., Fox, J. K., O’Neil, J. J., & Kieffer, T. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2955-4 · Cited by 216 · see citing works

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

Liu, Q., Chiu, A., Wang, L.-H., An, D., Zhong, M., Smink, A. M., de Haan, B. J., de Vos, P., Keane, K., Vegge, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13238-7 · Cited by 202 · see citing works

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

An, D., Chiu, A., Flanders, J. A., Song, W., Shou, D., Lu, Y.-C., Grunnet, L. G., Winkel, L., Ingvorsen, C., Christophersen, N. S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708806115 · Cited by 200 · cited 2× · see citing works

PARACRINE INTERACTIONS WITHIN THE PANCREATIC ISLET DETERMINE THE GLYCEMIC SET POINT

Rodriguez-Diaz, R., Molano, R., Weitz, J., Abdulreda, M., Berman, D., Leibiger, B., Leibiger, I., Kenyon, N., Ricordi, C., Pileggi, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.015 · Cited by 188 · see citing works

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

Maxwell, K. G., Augsornworawat, P., Velazco-Cruz, L., Kim, M. H., Asada, R., Hogrebe, N. J., Morikawa, S., Urano, F., & Millman, J. R. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax9106 · Cited by 183 · see citing works

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

Weaver, J. D., Headen, D. M., Aquart, J., Johnson, C. T., Shea, L. D., Shirwan, H., & García, A. J. (2017) · Science Advances · doi:10.1126/sciadv.1700184 · Cited by 170 · see citing works

Prevention of Diabetes for up to 13 Years by Autoislet Transplantation After Pancreatectomy for Chronic Pancreatitis

Robertson, R. P., Lanz, K. J., Sutherland, D. E. R., & Kendall, D. M. (2001) · Diabetes · doi:10.2337/diabetes.50.1.47 · Cited by 169 · see citing works

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Ricordi, C., Goldstein, J., Balamurugan, A., Szot, G., Kin, T., Liu, C.-Y., Czarniecki, C., Barbaro, B., Bridges, N., Cano, J., et al. (2016) · Diabetes · doi:10.2337/db16-0234 · Cited by 166 · see citing works

Hydrogels in Emerging Technologies for Type 1 Diabetes

Fuchs, S., Ernst, A. U., Wang, L., Shariati, K., Wang, X., Liu, Q., & Ma, M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01062 · Cited by 160 · see citing works

Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages

Jiang, K., Weaver, J. D., Li, Y., Chen, X., Liang, J., & Stabler, C. L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.004 · Cited by 154 · see citing works

Scientific and Political Impediments to Successful Islet Transplantation

Weir, G. C., & Bonner‐Weir, S. (1997) · Diabetes · doi:10.2337/diab.46.8.1247 · Cited by 139 · see citing works

The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts

Kumagai-Braesch, M., Jacobson, S., Mori, H., Jia, X., Takahashi, T., Wernerson, A., Flodström-Tullberg, M., & Tibell, A. (2013) · Cell Transplantation · doi:10.3727/096368912x657486 · Cited by 138 · see citing works

Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

Omer, A., Duvivier-Kali, V. F., Trivedi, N., Wilmot, K., Bonner‐Weir, S., & Weir, G. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.69 · Cited by 136 · see citing works

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Åkerfeldt, M. C., Howes, J. E., Chan, J. Y., Stevens, V. A., Boubenna, N., McGuire, H. M., King, C., Biden, T. J., & Laybutt, D. R. (2008) · Diabetes · doi:10.2337/db07-1802 · Cited by 134 · see citing works

Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets

Vlahos, A. E., Cober, N., & Sefton, M. V. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619216114 · Cited by 132 · see citing works

Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

Alagpulinsa, D. A., Cao, J. J. L., Driscoll, R. K., Sîrbulescu, R. F., Penson, M. F. E., Sremac, M., Engquist, E. N., Brauns, T. A., Markmann, J. F., Melton, D. A., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15308 · Cited by 130 · see citing works

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

Dang, T. T., Thai, A. V., Cohen, J., Slosberg, J. E., Siniakowicz, K., Doloff, J. C., Ma, M., Hollister-Lock, J., Tang, K. M., Gu, Z., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.016 · Cited by 125 · see citing works

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

Latres, E., Finan, D. A., Greenstein, J. L., Kowalski, A. J., & Kieffer, T. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.007 · Cited by 118 · see citing works

Engineering the vasculature for islet transplantation

Bowers, D. T., Song, W., Wang, L., & Ma, M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.051 · Cited by 113 · see citing works

Rapamycin Impairs In Vivo Proliferation of Islet Beta-Cells

Zahr, E., Molano, R. D., Pileggi, A., Ichii, H., Jose, S. S., Bocca, N., An, W., Gonzalez‐Quintana, J., Fraker, C. A., Ricordi, C., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000296035.48728.28 · Cited by 112 · see citing works

CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

Harper, S., Ali, J. M., Wlodek, E., Negus, M. C., Harper, I. G., Chhabra, M., Qureshi, M. S., Hoff, M., Bolton, E. M., Bradley, J. A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513533112 · Cited by 108 · see citing works

Engineering transferrable microvascular meshes for subcutaneous islet transplantation

Song, W., Chiu, A., Wang, L., Schwartz, R. E., Li, B., Bouklas, N., Bowers, D. T., An, D., Cheong, S. H., Flanders, J. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12373-5 · Cited by 104 · see citing works

Autologous Pluripotent Stem Cell–Derived β-Like Cells for Diabetes Cellular Therapy

Millman, J., & Pagliuca, F. (2017) · Diabetes · doi:10.2337/db16-1406 · Cited by 97 · see citing works

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

Pepper, A. R., Pawlick, R., Bruni, A., Wink, J., Rafiei, Y., O’Gorman, D., Yan-Do, R., Gala-Lopez, B., Kin, T., MacDonald, P. E., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.004 · Cited by 96 · see citing works

Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy

Chang, R., Faleo, G., Russ, H. A., Parent, A. V., Elledge, S. K., Bernards, D. A., Allen, J. L., Villanueva, K. E., Hebrok, M., Tang, Q., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01239 · Cited by 95 · see citing works

Impact of Oxygen on Pancreatic Islet Survival

Komatsu, H., Kandeel, F., & Mullen, Y. (2018) · Pancreas · doi:10.1097/mpa.0000000000001050 · Cited by 87 · see citing works

Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices

Nyitray, C. E., Chang, R., Faleo, G., Lance, K. D., Bernards, D. A., Tang, Q., & Desai, T. (2015) · ACS Nano · doi:10.1021/acsnano.5b00679 · Cited by 87 · see citing works

Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

Mooney, J. E., Rolfe, B. E., Osborne, G. W., Sester, D. P., van Rooijen, N., Campbell, G. R., Hume, D. A., & Campbell, J. H. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090545 · Cited by 87 · see citing works

Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine

Chen, S., Wang, H., McCarthy, A. D., Yan, Z., Kim, H. J., Carlson, M. A., Younan Xia, A., & Xie, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00217 · Cited by 85 · see citing works

Haemopoietic Origin of Myofibroblasts Formed in the Peritoneal Cavity in Response to a Foreign Body

Campbell, J. H., Efendy, J. L., Han, C., Girjes, A. A., & CAMPBELL, G. R. (2000) · Journal of Vascular Research · doi:10.1159/000025752 · Cited by 82 · see citing works

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

Robert, T., Mesmaeker, I. D., Stangé, G., Suenens, K., Ling, Z., Kroon, E. J., & Pipeleers, D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.040 · Cited by 75 · see citing works

Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane

Wang, K., Hou, W., Wang, X., Han, C., Vuletic, I., Su, N., Zhang, W., Ren, Q., Chen, L., & Luo, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.028 · Cited by 74 · see citing works

Nanotechnology in cell replacement therapies for type 1 diabetes

Ernst, A. U., Bowers, D. T., Wang, L., Shariati, K., Plesser, M. D., Brown, N. K., Mehrabyan, T., & Ma, M. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.013 · Cited by 74 · see citing works

Oxygenation strategies for encapsulated islet and beta cell transplants.

Papas, K., Leon, H. D., Suszynski, T., & Johnson, R. C. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.002 · Cited by 74 · see citing works

A bilaminated decellularized scaffold for islet transplantation: Structure, properties and functions in diabetic mice.

Wang, X., Wang, K., Zhang, W., Qiang, M., & Luo, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.033 · Cited by 50 · see citing works

Cytotoxic effect of IFN-γ plus TNF-α on human islet cells

Soldevila, G., Buscema, M., Doshi, M., James, R. F. L., Bottazzo, G. F., & Pujol‐Borrell, R. (1991) · Journal of Autoimmunity · doi:10.1016/0896-8411(91)90025-8 · Cited by 49 · see citing works

Encapsulate this

Dolgin, E. (2014) · Nature Medicine · doi:10.1038/nm0114-9 · Cited by 47 · see citing works

Islet encapsulation

Ernst, A. U., Wang, L., & Ma, M. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb02020e · Cited by 47 · see citing works

Diabetes: Encapsulating the problem

Dolgin, E. (2016) · Nature · doi:10.1038/540s60a · Cited by 43 · see citing works

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice

Haller, C., Piccand, J., Franceschi, F. D., Ohi, Y., Bhoumik, A., Boss, C., de Marchi, U., Jacot, G. E., Métairon, S., Descombes, P., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.02.002 · Cited by 40 · see citing works

Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model

Krishnan, R., Arora, R. P., Alexander, M., White, S. M., Lamb, M. W., Foster, C. E., Choi, B., & Lakey, J. R. T. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.012 · Cited by 27 · see citing works

Islet encapsulation therapy — racing towards the finish line?

Desai, T. A., & Tang, Q. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0100-7 · Cited by 25 · see citing works

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Wang, K., Wang, X., Han, C., Chen, L., & Luo, Y. (2017) · Journal of Visualized Experiments · doi:10.3791/54995 · Cited by 19 · see citing works

Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device

Faleo, G., Lee, K., Nguyen, V., & Tang, Q. (2016) · Transplantation · doi:10.1097/tp.0000000000001146 · Cited by 17 · see citing works

Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells

Mesmaeker, I. D., Robert, T., Suenens, K. G., Stangé, G. M., Hulle, F. O. V., Ling, Z., Tomme, P., Jacobs‐Tulleneers‐Thevissen, D., Keymeulen, B., & PIPELEERS, D. G. (2018) · Diabetes · doi:10.2337/db18-0709 · Cited by 16 · see citing works

Encapsulate this: the do's and don'ts

Orive, G., Emerich, D. F., & de Vos, P. (2014) · Nature Medicine · doi:10.1038/nm.3486 · Cited by 13 · see citing works

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Wang, K., Wang, X., Han, C., Chen, L., & Luo, Y. (2017) · Journal of Visualized Experiments · doi:10.3791/54995-v · Cited by 9 · see citing works

Modified alginates provide a long-term disguise against the foreign body response

Bray, N. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.41 · Cited by 7 · see citing works

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez, J. L., & Woodrow, K. A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102087 · Cited by 270 · see citing works

Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes

Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · see citing works

New Insights and Potential Therapeutic Interventions in Metabolic Diseases

Clemente‐Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., López-Mora, C., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310672 · Cited by 166 · see citing works

Solid implantable devices for sustained drug delivery

Magill, E., Demartis, S., Gavini, E., Permana, A. D., Thakur, R. R. S., Adrianto, M. F., Waite, D. T., Glover, K., Picco, C. J., Korelidou, A., et al. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114950 · Cited by 146 · see citing works

Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

Cayabyab, F., Nih, L. R., & Yoshihara, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.732431 · Cited by 119 · see citing works

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

Toren, E., Burnette, K., Banerjee, R. R., Hunter, C. S., & Tse, H. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756548 · Cited by 110 · see citing works

Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification

Augsornworawat, P., Hogrebe, N. J., Ishahak, M., Schmidt, M. D., Marquez, E., Maestas, M. M., Veronese-Paniagua, D., Gale, S. E., Miller, J. R., Velazco-Cruz, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01150-8 · Cited by 85 · see citing works

Advances in Encapsulation and Delivery Strategies for Islet Transplantation

Wu, S., Wang, L., Fang, Y., Huang, H. W., You, X., & Wu, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100965 · Cited by 78 · see citing works

Stem Cell Transplantation in the Treatment of Type 1 Diabetes Mellitus: From Insulin Replacement to Beta-Cell Replacement

Wan, X.-X., Zhang, D.-Y., Khan, M. A., Zheng, S.-Y., Hu, X., Zhāng, Q., Yang, R., & Xiong, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.859638 · Cited by 67 · see citing works

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Kavand, A., Noverraz, F., & Gerber‐Lemaire, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040469 · Cited by 64 · see citing works

Chemically engineering cells for precision medicine

Wang, Y., Li, Z., Mo, F., Chen‐Mayfield, T., Saini, A., LaMere, A. M., & Hu, Q. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00142j · Cited by 62 · see citing works

Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression

Wang, X., Wang, K., Yu, M., Velluto, D., Hong, X., Wang, B., Chiu, A., Melero-Martin, J. M., Tomei, A. A., & Ma, M. (2022) · Science Advances · doi:10.1126/sciadv.abn0071 · Cited by 62 · see citing works

Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate

Mukherjee, S., Kim, B., Cheng, L. Y., Doerfert, M., Li, J., Hernández, A., Liang, L. R., Jarvis, M., Rios, P., Ghani, S., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01016-2 · Cited by 60 · see citing works

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

Chen, J., Caserto, J. S., Ang, I., Shariati, K., Webb, J., Wang, B., Wang, X., Bouklas, N., & Ma, M. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.11.038 · Cited by 57 · see citing works

Pancreatic islet transplantation: current advances and challenges

Wang, Q., Huang, Y.-X., Liu, L., Zhao, X.-H., Sun, Y., Mao, X.-L., & Li, S.-W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391504 · Cited by 63 · see citing works

Monolithic-to-focal evolving biointerfaces in tissue regeneration and bioelectronics

Shi, J., Lin, Y., Li, P., Mickel, P., Sun, C., Parekh, K., Ma, J., Kim, S., Ashwood, B., Meng, L., et al. (2024) · Nature Chemical Engineering · doi:10.1038/s44286-023-00008-y · Cited by 56 · see citing works

Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation

Maxwell, K. G., Kim, M. H., Gale, S. E., & Millman, J. R. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab013 · Cited by 54 · see citing works

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Li, X., Xu, X., Wang, K., Chen, Y., Zhang, Y., Si, Q., Pan, Z., Jia, F., Cui, X., Wang, X., et al. (2023) · Advanced Materials · doi:10.1002/adma.202208820 · Cited by 52 · see citing works

Identification of unique cell type responses in pancreatic islets to stress

Maestas, M. M., Ishahak, M., Augsornworawat, P., Veronese-Paniagua, D., Maxwell, K. G., Velazco-Cruz, L., Marquez, E., Sun, J., Shunkarova, M., Gale, S. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49724-w · Cited by 51 · see citing works

Considerations and Challenges of Islet Transplantation and Future Therapies on the Horizon.

Walker, S. L., Appari, M., & Forbes, S. (2021) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2021 · Cited by 43 · see citing works

Emerging strategies for beta cell transplantation to treat diabetes

Paez‐Mayorga, J., Lukin, I., Emerich, D. F., de Vos, P., Orive, G., & Grattoni, A. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.11.007 · Cited by 43 · see citing works

Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes

Tahbaz, M., & Yoshihara, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.716625 · Cited by 42 · see citing works

Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes

Citro, A., Neroni, A., Pignatelli, C., Campo, F., Policardi, M., Monieri, M., Pellegrini, S., Dugnani, E., Manenti, F., Maffia, M. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36582-1 · Cited by 41 · see citing works

Macroencapsulation devices for cell therapy

Liu, W., Wang, Y., Wang, J.-Q., Lanier, O. L., Wechsler, M., Peppas, N., & Gu, Z. (2022) · Engineering · doi:10.1016/j.eng.2021.10.021 · Cited by 32 · see citing works

Hydrogels: Definition, History, Classifications, Formation, Constitutive Characteristics, and Applications

Dodda, J. M., Deshmukh, K., Bezuidenhout, D., & Yeh, Y. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837670055-00001 · Cited by 37 · see citing works

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets

Ramzy, A., Belmonte, P. J., Braam, M. J. S., Ida, S., Wilts, E. M., Levings, M. K., Rezania, A., & Kieffer, T. J. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac021 · Cited by 36 · see citing works

Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression

Wang, L., Marfil‐Garza, B. A., Ernst, A. U., Pawlick, R. L., Pepper, A. R., Okada, K., Epel, B., Viswakarma, N., Kotecha, M., Flanders, J. A., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01145-8 · Cited by 38 · see citing works

Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective

Kalashnikov, N., Barralet, J. E., & Vorstenbosch, J. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37983 · Cited by 38 · see citing works

Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment

Qin, T., Smink, A. M., & de Vos, P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.06.038 · Cited by 35 · see citing works

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Xiao, Z., Wei, T., Ge, R., Li, Q., Лю, Б., Ji, Z., Chen, L., Zhu, J., Shen, J., Liu, Z., et al. (2022) · Small · doi:10.1002/smll.202202596 · Cited by 34 · see citing works

Immunocompatible elastomer with increased resistance to the foreign body response

Zhou, X., Lu, Z., Cao, W., Zhu, Z., Chen, Y., Ni, Y., Liu, Z., Jia, F., Yang, Y., Han, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52023-z · Cited by 35 · see citing works

Encapsulation and immune protection for type 1 diabetes cell therapy

Kioulaphides, S., & Garcı́a, A. J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115205 · Cited by 34 · see citing works

An elastomer with in situ generated pure zwitterionic surfaces for fibrosis-resistant implants

Zhou, X., Cao, W., Chen, Y., Zhu, Z., Lai, Y., Liu, Z., Jia, F., Lu, Z., Han, H., Yao, K., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.06.047 · Cited by 30 · see citing works

Immunomodulatory hydrogels for tissue repair and regeneration

Liu, X., Hu, Y., Ju, Y., Yang, P. S., Shen, N., Yang, A., Wu, R., Fang, B., & Liu, L. (2024) · APL Materials · doi:10.1063/5.0228692 · Cited by 32 · see citing works

Cell delivery systems: Toward the next generation of cell therapies for type 1 diabetes

Dang, H. P., Chen, H., Dargaville, T. R., & Tuch, B. E. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17499 · Cited by 28 · see citing works

Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

Chang, Y., Chang, M., Bao, X., & Dong, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.046 · Cited by 26 · see citing works

Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation

Campa‐Carranza, J. N., Paez‐Mayorga, J., Chua, C. Y. X., Nichols, J. E., & Grattoni, A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2076834 · Cited by 28 · see citing works

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells

Jin, W., & Jiang, W. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00125-8 · Cited by 25 · see citing works

Pancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes

Huan, Z., Li, J., Guo, J., Yu, Y., & Li, L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.047 · Cited by 24 · see citing works

A porcine islet-encapsulation device that enables long-term discordant xenotransplantation in immunocompetent diabetic mice

Ajima, K., Tsuda, N., Takaki, T., Furusako, S., Matsumoto, S., Shinohara, K., Yamashita, Y., Amano, S., Oyama, C., & Shimoda, M. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100370 · Cited by 21 · see citing works

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Grimus, S., Sarangova, V., Welzel, P. B., Ludwig, B., Seißler, J., Kemter, E., Wolf, E., & Ali, A. (2024) · Advanced Science · doi:10.1002/advs.202401385 · Cited by 21 · see citing works

iPS cell therapy 2.0: Preparing for next‐generation regenerative medicine

Hui, K. K., & Yamanaka, S. (2024) · BioEssays · doi:10.1002/bies.202400072 · Cited by 22 · see citing works

Recent advances in biomaterial-assisted cell therapy

Chen, Y., Pal, S., & Hu, Q. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00583b · Cited by 19 · see citing works

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment.

Chen, S., Wang, W., Shen, L., Liu, H.-F., Luo, J., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F.-Y., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 20 · see citing works

3D Printing Mini-Capsule Device for Islet Delivery to Treat Type 1 Diabetes

Chen, S., Luo, J. C., Shen, L., Liu, X., Wang, W., Xu, J. M., Ren, Y., Ye, Y., Shi, G., Cheng, F., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02487 · Cited by 18 · see citing works

The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy

Wang, X., Gao, M., Wang, Y.-L., & Zhang, Y.-C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.927324 · Cited by 22 · see citing works

Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease

Kim, K. M., D’Elia, A. M., & Rodell, C. B. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115395 · Cited by 19 · see citing works

Mouse models and human islet transplantation sites for intravital imaging

Wagner, L. E., Melnyk, O., Duffett, B. E., & Linnemann, A. K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992540 · Cited by 18 · see citing works

An injectable and retrievable bioartificial pancreas fabricated by time-sequentially assembling islets-laden microgels for minimally invasive treatment of type 1 diabetes

He, W., Li, H., Xu, X., Zhang, X., Chen, J., Lv, C., Yu, H., Feng, Q., & Dong, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152261 · Cited by 15 · see citing works

Advancements and Challenges in Immune Protection Strategies for Islet Transplantation

Wang, X., Zeng, Z., Li, D., Wang, K., Zhang, W., Yu, Y., & Wang, X. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70048 · Cited by 15 · see citing works

Benefits and Hurdles of Pancreatic β-Cell Replacement

Bolla, A. M., Montefusco, L. B., Pastore, I., Lunati, M. E., Nasr, M. B., & Fiorina, P. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac058 · Cited by 15 · see citing works

Emerging approaches for the development of artificial islets

Li, J., Sun, L., Bian, F.-K., Pandol, S., & Li, L. (2024) · Smart Medicine · doi:10.1002/smmd.20230042 · Cited by 10 · see citing works

Recent progress in modeling and treating diabetes using stem cell-derived islets

Maestas, M. M., Bui, M. H., & Millman, J. R. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae059 · Cited by 14 · see citing works

A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Pham, T. T., Tran, P. L., Tempelman, L. A., Stone, S. G., Piccirillo, C., Li, A., Flanders, J. A., & Ma, M. (2025) · Nature Communications · doi:10.1038/s41467-025-62271-2 · Cited by 17 · see citing works

An electrospun macrodevice for durable encapsulation of human cells with consistent secretion of therapeutic antibodies

Imaichi, S., Kassab, R., Piersigilli, A., Robertson, R., Leonard, C., Long, N., Dean, B., Phaneuf, M. D., & Ling, V. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122123 · Cited by 13 · see citing works

An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors.

Huang, Y., Xu, Y., Zhu, J.-C., Wan, J., Xiong, Y., Jiang, Z.-Y., Zhu, S.-J., Guo, Q.-S., Li, Y.-X., Lu, Y.-H., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121882 · Cited by 12 · see citing works

Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

Li, H., Li, D., Wang, X., Zeng, Z., Pahlavan, S., Zhang, W., Wang, X., & Wang, K. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01106 · Cited by 12 · see citing works

Immune Evasion in Stem Cell-Based Diabetes Therapy—Current Strategies and Their Application in Clinical Trials

Mu-u-min, R., Diané, A., Allouch, A., & Al-Siddiqi, H. (2025) · Biomedicines · doi:10.3390/biomedicines13020383 · Cited by 13 · see citing works

Islet transplantation in immunomodulatory nanoparticle–remodeled spleens

Liu, M., Deng, H., Liu, C., Wang, L., Liao, Z., Li, D., Chen, Y., Li, J., Dong, J., Sun, X., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adj9615 · Cited by 12 · see citing works

Improving cellular fitness of human stem cell-derived islets under hypoxia

Wang, X., Brielle, S., Kenty, J. H.-R., Korover, N., Bavli, D., Pop, R., & Melton, D. A. (2025) · Nature Communications · doi:10.1038/s41467-025-59924-7 · Cited by 13 · see citing works

Engineering a Hierarchical Biphasic Gel for Subcutaneous Vascularization

Gao, D., Ernst, A. U., Wang, X., Wang, L., Liu, W. H., & Ma, M. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200922 · Cited by 12 · see citing works

Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets

Einstein, S. A., Steyn, L., Weegman, B., Suszynski, T., Sambanis, A., O'Brien, T. D., Avgoustiniatos, E., Firpo, M., Graham, M. L., Janecek, J., et al. (2023) · Frontiers in Transplantation · doi:10.3389/frtra.2023.1257029 · Cited by 10 · see citing works

New insights into β-cell failure, regeneration and replacement

Bakhti, M., & Lickert, H. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00611-0 · Cited by 11 · see citing works

Biomimetic cell encapsulations by microfluidics

Wang, J., Huang, D., Fang, Y., Ren, H., & Zhao, Y. (2024) · Science China Materials · doi:10.1007/s40843-024-2903-0 · Cited by 10 · see citing works

Therapeutic Effects of Insulin-Producing Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Type 1 Diabetes Mouse Model

Park, Y. M., Yang, C. M., & Cho, H. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136877 · Cited by 10 · see citing works

Mechanically reinforced hydrogel vehicle delivering angiogenic factor for beta cell therapy

Toftdal, M. S., Christensen, N. P., Kadumudi, F. B., Dolatshahi‐Pirouz, A., Grunnet, L. G., & Chen, M. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.04.050 · Cited by 10 · see citing works

Emerging Strategies for Beta Cell Encapsulation for Type 1 Diabetes Therapy

Toftdal, M. S., Grunnet, L. G., & Chen, M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400185 · Cited by 9 · see citing works

High‐Efficiency, Prevascularization‐Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment

Jeon, S., Heo, J., Myung, N., Shin, J. Y., Kim, M. K., & Kang, H. (2024) · Advanced Materials · doi:10.1002/adma.202408329 · Cited by 9 · see citing works

Integrating Additive Manufacturing Techniques to Improve Cell‐Based Implants for the Treatment of Type 1 Diabetes

Accolla, R. P., Simmons, A., & Stabler, C. L. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200243 · Cited by 9 · see citing works

Unlocking Transplant Tolerance with Biomaterials

Pham, J. A., & Coronel, M. M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400965 · Cited by 8 · see citing works

The future of islet transplantation beyond the BLA approval: challenges and opportunities

Wang, Y., McGarrigle, J. J., Cook, J., Rios, P., Monica, G. L., Chen, Y., Wei, W., & Oberholzer, J. (2025) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1522409 · Cited by 9 · see citing works

Best practices in islet transplantation in mice.

Meier, R. P. H., Nasr, M. B., Fife, B., Finger, E. B., Fiorina, P., Luo, X., & Bromberg, J. (2025) · American Journal of Transplantation · doi:10.1016/j.ajt.2025.03.008 · Cited by 8 · see citing works

Gene editing strategies to address current challenges in stem cell-derived β cell therapy for type 1 Diabetes

Han, J., Lim, D., & Yang, K. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251373039 · Cited by 8 · see citing works

Overcoming barriers to delivery of biologics by novel approaches and advanced delivery systems

Ahator, S. D., Franzè, S., Obuobi, S. A. O., Anderluzzi, G., Flaten, G. E., & Škalko‐Basnet, N. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115875 · Cited by 8 · see citing works

Human amniotic mesenchymal stem cell-islet organoids enhance the efficiency of islet engraftment in a mouse diabetes model

Zhou, J.-X., Jie-Zhou, Jin, W.-R., Li, J., Zhang, X.-C., Zhao, C.-Y., Lin, Y.-Y., Wang, X., Yan, L.-F., Kaiyan, et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122812 · Cited by 8 · see citing works

Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes

Chaudhary, D., Nguyen, T. T., Yook, S., & Jeong, J. (2023) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-023-00627-w · Cited by 7 · see citing works

The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges

Luo, Y., Yu, P., & Liu, J. (2024) · Endocrine · doi:10.1007/s12020-024-03855-8 · Cited by 7 · see citing works

Toward Systemic Lipofuscin Removal

Renteln, M. (2024) · Rejuvenation Research · doi:10.1089/rej.2024.0034 · Cited by 8 · see citing works

Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices

McDermott, B., Robinson, S. T., Holcombe, S. A., Levey, R. E., Dockery, P., Johnson, P., Wang, S. C., Dolan, E. B., & Duffy, G. P. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0673 · Cited by 7 · see citing works

Hydrogel-Bondable Asymmetric Planar Membranes with Hierarchical Pore Structures for Cell Scaffolding and Encapsulation

Wang, Y., Wang, K., Luo, Y., & Chen, H. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01415 · Cited by 7 · see citing works

Biomimetic artificial islet model with vascularized microcapsule structures for durable glycemic control

Li, J., Fang, Y., Wu, Z.-H., Shang, L.-R., & Li, L. (2024) · Materials Futures · doi:10.1088/2752-5724/ad47ce · Cited by 6 · see citing works

Can nanotechnology overcome challenges facing stem cell therapy? A review

Zaghary, W. A., Elansary, M. M., Shouman, D. N., Abdelrahim, A. A., Abu‐Zied, K. M., & Sakr, T. M. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102883 · Cited by 8 · see citing works

A pluripotent road to immunoengineering

Chang, Y., Deng, Q., & Bao, X. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00056-2 · Cited by 6 · see citing works

A durable immuno-protective core-shell microgel for the enhanced pancreatic islet transplantation in diabetes therapy

Hu, Z., Luo, Y., Junaid, M., Xu, R., Chen, Y., Yao, J., Ni, R., Zhu, T., Zhang, H., Ding, H., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169527 · Cited by 5 · see citing works

Stem cells as a therapeutic avenue for active and long-term complications of Necrotizing Enterocolitis

Mesfin, F. M., Manohar, K., Shelley, W. C., Brokaw, J. P., Liu, J., Ma, M., & Markel, T. A. (2023) · Seminars in Pediatric Surgery · doi:10.1016/j.sempedsurg.2023.151311 · Cited by 4 · see citing works

Designing next-generation islet-like cells from human pluripotent stem cells: Advances in overcoming allorejection and recurrent type 1 Diabetes

Misra, P. S., & Nostro, M. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100321 · Cited by 4 · see citing works

Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

Khazaei, M., Khazaei, F., Niromand, E., & Ghanbari, E. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2107653 · Cited by 4 · see citing works

Transplantable cell-encapsulation device using a semipermeable ethylene-vinyl alcohol copolymer membrane in a mouse diabetic model

Kaneko, M., Moriguchi, H., Futatsubashi, R., Ayano, S., Kobayashi, G., & Itô, A. (2023) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2023.09.001 · Cited by 4 · see citing works

Silencing hsa_circ_0032449 inhibits the pancreatic differentiation of human embryonic stem cells via the hsa_miR-195-5p/CCND1/PI3K/AKT signaling pathway

Xu, Y., Xu, T., Huang, Y. H., Wan, J., & Jiang, Z. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113879 · Cited by 3 · see citing works

Next-gen therapeutics to spare and expand beta-cell mass

Bolla, A. M., Usuelli, V., Nasr, M. B., Frigerio, S., Loretelli, C., D’Addio, F., & Fiorina, P. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.09.001 · Cited by 3 · see citing works

Fabrication of nanofibrous mat surrounded hydrogel scaffold as an encapsulation device for encapsulating pancreas β cells

Seyyedi, M. S., Monfared, M., Mirzaei, E., & Azarpira, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-25736-8 · Cited by 3 · see citing works

Hydrogel-Composited Laminate for Islet Immune-Isolation to Treat Type 1 Diabetes

Wang, Y., Wang, K., Wang, X., Luo, Y., & Chen, H. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c12359 · Cited by 3 · see citing works

Bio‐Inspired Pancreas With Microfluidic Multi‐Component Hydrogel Microfibers for Exploring Pancreatic Exocrine and Endocrine Interactions

Huan, Z., Luo, Z., Li, J., Yu, Y., & Li, L. (2025) · Aggregate · doi:10.1002/agt2.70210 · Cited by 2 · see citing works

Type 1 Diabetes and Islet Encapsulation: From Historical Milestones to Cutting-Edge Advances

Mukherjee, S., Mandal, S., Oberholzer, J., & Omid Veiseh, A. (2026) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110824-024435 · Cited by 2 · see citing works

Advancing diabetes treatment: from human beta cell technology to bioartificial pancreas development

Sá, J., Sá, S. C., Leménager, H., Costa, R., Onteniente, B., Soares, R. A., Ribeiro, V. P., & de Oliveira, A. L. F. (2025) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2025.1524518 · Cited by 3 · see citing works

Amniotic Membrane and Mesenchymal Stem Cell Coalescence for Islet Transplantation in Experimental Diabetes in Rats

Tiryaki, M., Atmaca, N., Pinarli, F., Böyük, G., Feyat, M. S., Mercan, S., Albayrak, A., & Atmaca, H. (2025) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/term/2645595 · Cited by 1 · see citing works

A stepwise funnel selection approach identifying natural polymer-derived hydrogels for long-term islet delivery, restoring normoglycemia in type-1 diabetes

Mandal, S., Yenurkar, D., Manna, S., Bhattacharjee, R., Nayak, M., Pradhan, L., & Mukherjee, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb02371h · Cited by 1 · see citing works

Whole-genome CRISPR screening identifies genetic modifiers of stem cell–derived islet transplantation

Maestas, M. M., Bradley, K., Shunkarova, M., Mukherjee, N., Ishahak, M., Lu, J., & Millman, J. R. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag012 · Cited by 1 · see citing works

Tissue‐Material Characteristics Determine Fibrous Encapsulation Dynamics Across Common Polymeric Surgical Biomaterials in a Tissue‐Specific Mouse Foreign Body Response Model

Kalashnikov, N., Thareja, R., & Vorstenbosch, J. (2026) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.70096 · Cited by 1 · see citing works

Pancreatic tissue engineering: towards a vascularized bioengineered cure for diabetes

Park, J., Olawuyi, K., Jikaria, N. R., Dawes, J. S., Dabsha, I. E., Dick, A. A., & Ravnic, D. J. (2026) · Frontiers in Transplantation · doi:10.3389/frtra.2026.1768497 · Cited by 1 · see citing works

A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Liu, W. H., Flanders, J. A., Wang, L., Liu, Q., Bowers, D. T., Wang, K., Chiu, A., Wang, X., Ernst, A. U., Shariati, K., et al. (2021) · Small · doi:10.1002/smll.202104899 · Cited by 53 · see citing works

Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

Lee, S., Hao, E., Savinov, A., Geron, I., Strongin, A., & Itkin-Ansari, P. (2009) · Transplantation · doi:10.1097/tp.0b013e31819c86ea · Cited by 119 · see citing works

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment.

Chen, S., Wang, W., Shen, L., Liu, H.-F., Luo, J., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F.-Y., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 20 · see citing works

P-10: STRUCTURAL AND FUNCTIONAL PRELIMINARY ASSESSMENT OF AN ENCAPSULATION DEVICE FOR Β-CELLS SPHEROIDS USING A SEMIPERMEABLE MEMBRANE

Miceli, V., Castelbuono, S., Cuscino, N., Zito, G., Centi, C., Tinnirello, R., Cimino, M., Pinzani, M., Conaldi, P. G., & Mattina, A. (2025) · Transplantation · doi:10.1097/01.tp.0001123412.40447.5a

07-2: A PERFUSABLE ENCAPSULATION DEVICE SCALED FOR CLINICALLY RELEVANT THERAPEUTIC ISLET DOSES SHOWS RAPID INSULIN RESPONSE IN VITRO AND ACUTE SAFETY IN PIG TRANSPLANTATION MODEL

Vdovenko, D., Sidharthan, D. S., Brassard, J. A., Ruel, J., Bégin‐Drolet, A., Paraskevas, S., Gasparrini, M., Leask, R. L., Kieffer, T. J., & Hoesli, C. A. (2025) · Transplantation · doi:10.1097/01.tp.0001123064.83133.9a · Cited by 1 · see citing works