The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
ER-mitochondria tethering by PDZD8 regulates Ca 2+ dynamics in mammalian neurons
Open accessAbstract
Making the right contacts: Contacts between the endoplasmic reticulum (ER) and mitochondria mediate key physiological processes such as Ca 2+ exchange and lipid biogenesis. wiIn yeast, ER and mitochondria are tethered by a complex of four proteins called ERMES. However, no functional orthologs of these ERMES complex proteins have been identified in metazoans. Hirabayashi et al. identified PDZD8 as a structural and functional ortholog of the yeast ERMES protein MMM1 (see the Perspective by Lombardi and Elrod). PDZD8 was found at ER-mitochondria contact sites and was required for ER-mitochondria tethering in mammalian cells. In neuronal dendrites, PDZD8 regulated synaptically evoked Ca 2+ dynamics, which underscores the importance of interorganelle membrane contacts in cell physiology. Science , this issue p. 623 ; see also p. 591
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Genome engineering using the CRISPR-Cas9 system
Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133
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Kelley, L. A., Mezulis, S., Yates, C. M., Wass, M. N., & Sternberg, M. J. E. (2015) · Nature Protocols · doi:10.1038/nprot.2015.053 · Cited by 9,652
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science · doi:10.1126/science.1175088 · Cited by 1,275
Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018
Compartmentalized dendritic plasticity and input feature storage in neurons
Losonczy, A., Makara, J. K., & Magee, J. C. (2008) · Nature · doi:10.1038/nature06725 · Cited by 598
High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy
Tapia, J. C., Kasthuri, N., Hayworth, K. J., Schalek, R., Lichtman, J. W., Smith, S. J., & Buchanan, J. (2012) · Nature Protocols · doi:10.1038/nprot.2011.439 · Cited by 296
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Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele, T., Rey, T., Winter, J., Zaganelli, S., Mahecic, D., Perreten Lambert, H., Ruberto, F. P., Nemir, M., Wai, T., Pedrazzini, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03510-6 · Cited by 794
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Wong, L. H., Gatta, A. T., & Levine, T. P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0071-5 · Cited by 505
Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease
Nguyen, M., Wong, Y. C., Ysselstein, D., Severino, A., & Krainc, D. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.11.001 · Cited by 323
Metadata
- Authors
- Hirabayashi, Y., Kwon, S.-K., Paek, H., Pernice, W. M., Paul, M. A., Lee, J., Erfani, P., Raczkowski, A., Petrey, D. S., Pon, L. A., & Polleux, F.
- Venue
- Science
- Published
- 2017-11-03
- Volume
- 358
- Issue
- 6363
- Pages
- 623-630
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2766127467
- Cited by
- 493
- References
- 7
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- green
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