Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease
Open accessAbstract
The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endophilin A1), have also highlighted disruptions in synaptic vesicle endocytosis (SVE) as a significant contributor to disease pathogenesis. Additionally, the roles of other PD genes such as LRRK2, PRKN, and VPS35 in the regulation of SVE are beginning to emerge. Here we discuss the recent work on the contribution of dysfunctional SVE to midbrain dopaminergic neurons' selective vulnerability and highlight pathways that demonstrate the interplay of synaptic, mitochondrial, and lysosomal dysfunction in the pathogenesis of PD.
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Synaptic dysfunction contributes to disease pathogenesis in PD and may be linked to cognitive and motor dysfunction.
“Synaptic dysfunction contributes to disease pathogenesis in PD (Nguyen et al. 2019) and may be linked to cognitive and motor dysfunction (Bereczki et al. 2017; Moran et al. 2008).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Nguyen et al. 2019
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SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
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Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells
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TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology
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VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons
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Self-citationParkinson’s disease therapy: what lies ahead?
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Dysfunction of synaptic endocytic trafficking in Parkinson’s disease
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Endosomal sorting pathways in the pathogenesis of Parkinson's disease
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- Authors
- Nguyen, M., Wong, Y. C., Ysselstein, D., Severino, A., & Krainc, D.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Krainc, Dimitri
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 42
- Issue
- 2
- Pages
- 140-149
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC6452863
- OpenAlex
- W2903418495
- Cited by
- 323
- References
- 89
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 53 · 2023: 42 · 2022: 45 · 2021: 57 · 2020: 45 · 2019: 18
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (2T32AG020506-16, K99 NS109252, T32 NS041234, R01 NS076054, R37 NS096241)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Parkinson's disease, synaptic vesicle endocytosis, mitochondrial dysfunction, oxidative stress, DNAJC6, auxilin, SYNJ1, SH3GL2, endophilin A1, LRRK2, Parkin, VPS35, midbrain dopaminergic neurons, selective neuronal vulnerability, risk genes
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Animals, Autophagy, Dopamine, Endocytosis, Humans, Lysosomes, Mitochondria, Parkinson Disease, Synaptic Vesicles, Oxidative Stress, Genetic Predisposition to Disease, alpha-Synuclein, Dopaminergic Neurons
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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