Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

Features and development of Coot

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PHENIX : a comprehensive Python-based system for macromolecular structure solution

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Phaser crystallographic software

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XDS

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Inference of Macromolecular Assemblies from Crystalline State

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Universal sample preparation method for proteome analysis

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Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing

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Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1Preprint

Cui, Z., Esposito, A., Napolitano, G., Ballabio, A., & Hurley, J. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.15.623810 · Cited by 3

Trans-Endothelial Trafficking in Zebrafish: Nanobio Interactions of Polyethylene Glycol-Based Nanoparticles in Live Vasculature

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Integrin-dependent YAP signaling requires LAMTOR1 mediated delivery of Src to the plasma membranePreprint

Block, M. R., Brunner, M., Ziegelmeyer, T., Lallemand, D., Pezet, M., Chevalier, G., Rondé, P., Wehrle‐Haller, B., & Bouvard, D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/585349 · Cited by 2

A quantitative mapping approach to identify direct interactions within complexomesPreprint

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Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9Preprint

Guo, R., Lim, M. Y., Shah, H., Paulo, J. A., Zhang, Y., Yang, H., Wang, L. W., Strebinger, D., Smith, N., Li, M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4413958/v1 · Cited by 2

The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production

Feng, Z., Wang, L., Chen, S., Cao, S., Lei, M., Yang, X., Ma, K., Yu, S., Hu, H., Zheng, K., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00695-2 · Cited by 1

Lysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growth

Picot, M., Hifdi, N., Vaucourt, M., Mansat, M., Li, P., Singer, I. I., Chicanne, G., Stella, A., Shen, K., Miceli, C., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01484-1 · Cited by 1

Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway

Yang, S., Bian, T., & Zoncu, R. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.02.009 · Cited by 3

Spatial Transcriptomics Delineates the Inflammatory Landscape of Human Dental Pulp: Regional Crosstalk and Therapeutic Implications

Zhang, F., Kong, Y., Fu, X., Zuo, J., Guo, Q., Wang, J., Xu, M., Zeng, Q., Zhang, Y., ling, J., et al. (2026) · International Endodontic Journal · doi:10.1111/iej.70200 · Cited by 1

The difference is in the details: Structural and mechanistic variations in the LAMTOR-Gtr/Rag module

Titze, S., & Kümmel, D. (2023) · Structure · doi:10.1016/j.str.2023.08.003 · Cited by 1

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

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Papers of note in Science 358 (6366)

VanHook, A. M. (2017) · Science Signaling · doi:10.1126/scisignal.aar5580

Cross-linking of the Endolysosomal System Reveals Flotillin Structures and Putative CargoPreprint

Singh, J., Elhabashy, H., Muthukottiappan, P., Stepath, M., Eisenacher, M., Kohlbacher, O., Gieselmann, V., & Winter, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.12.475930

Papers of note in Science 358 (6361)

VanHook, A. M. (2017) · Science Signaling · doi:10.1126/scisignal.aar2565

Faculty Opinions recommendation of Structural basis for the docking of mTORC1 on the lysosomal surface.

Collins, B. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736733473.793566203

The deubiquitinase USP32 regulates non-proteolytic ubiquitination in the endosomal-lysosomal system

Hertel, A. (2021) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.62688

Faculty Opinions recommendation of Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Ferguson, S. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736741937.793574668

Faculty Opinions recommendation of Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Collins, B. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736741937.793566201

Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesisPreprint

Park, J., Zhang, S., Lee, S. H., Nie, L., Huang, Y., Zou, G., Jung, Y., Jun, S., Zhang, J., Lien, E. M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1546520/v1

mTORC1: Upstream and Downstream

Yao, Y., & Inoki, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00182-6

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEBPreprint

Cui, Z., Napolitano, G., de Araújo, M. E. G., Esposito, A., Monfregola, J., Huber, L. A., Ballabio, A., & Hurley, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.12.507619

Cross-Linking Mass Spectrometry Data Analysis

Zhou, C., & Yu, W. (2022) · Springer handbooks of computational statistics · doi:10.1007/978-3-662-65902-1_17

Estudos das relações evolutivas e funcionais da proteina viral HBx com as subunidades do complexo Ragulator

Lasso, J. A. L. (2021) · doi:10.47749/t/unicamp.2021.1239140

Caracterização das isoformas e interações da proteína HBXIP/Lamtor5, uma subunidade do complexo Ragulator

Gonçalves, M. P. (2021) · doi:10.47749/t/unicamp.2021.1233264

Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, JonathanPreprint

Vaisvil, B., Schmitt, D. P., Jones, A., Kapatral, V., Ford, J. M., Taylor, M. L., Colwell, M., Hollins, J., Pascucci, S., Weißenow, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.05.636284

Single-cell Resolution Spatial Transcriptomics Delineates the Inflammatory Landscape of Human Dental Pulp: Regional Crosstalk and Therapeutic ImplicationsPreprint

Zheng, J., Zhang, F., Kong, Y., Fu, X., Zuo, J., Guo, Q., Wang, J., Xu, M., Zeng, Q., Zhang, Y., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7096435/v1

Structural insight into GPR155-mediated cholesterol sensing and signal transduction

Li, D., Zhang, X., Feng, J., Xie, Y., Han, P., He, M., Lin, H., Guo, T., Bai, X., Yuan, K., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.09.012

Mechanism of isoleucyl-tRNA synthetase 2 regulating proliferation and apoptosis of cervical cancer cells

Bi, Y., Ye, Y., Wu, X., Huang, C., & Ma, Q. (2026) · Scientific Reports · doi:10.1038/s41598-026-41218-7

Role of p27/Kip1 in auphagy under metabolic stress conditions

Nowosad, A. (2018) · theses.fr (ABES) · doi:10.70675/11eb36d1zc3baz4d74z8d00zc049667c5976

Control of the invadopodia/MT1-MMP axis by mTORC1/TFEB signaling pathway in breast cancer cells

Remy, D. (2022) · theses.fr (ABES) · doi:10.70675/849dc96dz8e18z4428zbf6fz67c9b1d98114

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Vaisvil, B., Schmitt, D. P., Jones, A., Kapatral, V., Ford, J., Taylor, M. L., Colwell, M., Hollins, J., Pascucci, S., Weißenow, K., et al. (2026) · Science Advances · doi:10.1126/sciadv.adw8887 · Cited by 1

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

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Rare-Earth-Coordinated Glutamine Nanostructure-Induced “Pseudo-Overnutrition” Metabolic Therapy

Wang, J., Xu, M., Zhu, G., Zhang, S., Li, Y., Ma, P., Lin, J., & Li, C. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c13842

Structure of human mTORC1 components

Ray, L. B. (2017) · Science · doi:10.1126/science.358.6361.316-t

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

Su, M.-Y., Morris, K. K., Kim, D. J., Fu, Y., Lawrence, R. E., Stjepanović, G., Zoncu, R., & Hurley, J. H. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.193 · Cited by 2

Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane

Mu, Z., Wang, L., Deng, W., Wang, J., & Wu, G. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.49 · Cited by 63

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01762-3 · Cited by 75

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

Zhang, T., Wang, R., Wang, Z., Wang, X., Wang, F., & Ding, J. (2017) · Nature Communications · doi:10.1038/s41467-017-01567-4 · Cited by 72