The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow
Abstract
A reaction screen in flowing solvent: Chemists charged with manufacturing pharmaceuticals have recently been exploring the efficiency advantages of continuous flow techniques. Perera et al. now show that a flow apparatus can also accelerate reaction optimization earlier in the drug discovery process. They modified a high-performance liquid chromatography system to screen a wide variety of solvent, ligand, and base combinations to optimize carbon-carbon bond formation. Injecting stock solution aliquots of the catalyst and reactants into a carrier solvent stream let the authors vary the main solvent efficiently and scale up the optimal conditions for product isolation. Science , this issue p. 429
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Cites
Innovation in the pharmaceutical industry: New estimates of R&D costs
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The Hitchhiker’s Guide to Flow Chemistry
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Multiphase microfluidics: from flow characteristics to chemical and materials synthesis
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Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
Buitrago Santanilla, A., Regalado, E. L., Pereira, T., Shevlin, M., Bateman, K., Campeau, L.-C., Schneeweis, J., Berritt, S., Shi, Z.-C., Nantermet, P., et al. (2015) · Science · doi:10.1126/science.1259203 · Cited by 603
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A robotic platform for flow synthesis of organic compounds informed by AI planning
Coley, C. W., Thomas, D. A., Lummiss, J. A. M., Jaworski, J. N., Breen, C. P., Schultz, V., Hart, T., Fishman, J. S., Rogers, L., Gao, H., et al. (2019) · Science · doi:10.1126/science.aax1566 · Cited by 1,052
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Boiko, D. A., MacKnight, R., Kline, B., & Gomes, G. (2023) · Nature · doi:10.1038/s41586-023-06792-0 · Cited by 1,050
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Coley, C. W., Jin, W., Rogers, L., Jamison, T. F., Jaakkola, T. S., Green, W. H., Barzilay, R., & Jensen, K. F. (2019) · Chemical Science · doi:10.1039/c8sc04228d · Cited by 679
The importance of synthetic chemistry in the pharmaceutical industry
Campos, K. R., Coleman, P. J., Alvarez, J. C., Dreher, S. D., Garbaccio, R. M., Terrett, N. K., Tillyer, R. D., Truppo, M. D., & Parmee, E. R. (2019) · Science · doi:10.1126/science.aat0805 · Cited by 668
Metadata
- Authors
- Perera, D., Tucker, J. W., Brahmbhatt, S., Helal, C. J., Chong, A., Farrell, W., Richardson, P., & Sach, N. W.
- Venue
- Science
- Published
- 2018-01-26
- Volume
- 359
- Issue
- 6374
- Pages
- 429-434
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2784918212
- Cited by
- 465
- References
- 24
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perera, D., Tucker, J. W., Brahmbhatt, S., Helal, C. J., Chong, A., Farrell, W., Richardson, P., & Sach, N. W. (2018). A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow. Science. https://doi.org/10.1126/science.aap9112
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