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The importance of synthetic chemistry in the pharmaceutical industry
Abstract
Synthetic innovation in drug development: Chemical synthesis plays a key role in pharmaceutical research and development. Campos et al. review some of the advantages that have come from recent innovations in synthetic methods. In particular, they highlight small-molecule catalysts stimulated by visible light, enzymes engineered for versatility beyond their intrinsic function, and bio-orthogonal reactions to selectively modify proteins for conjugation. High-throughput techniques are also poised to accelerate methods optimization from small-scale discovery to large-scale production, and complementary machine-learning approaches are just coming into focus. Science , this issue p. eaat0805
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Predicting reaction performance in C–N cross-coupling using machine learning
Ahneman, D. T., Estrada, J. G., Lin, S., Dreher, S. D., & Doyle, A. G. (2018) · Science · doi:10.1126/science.aar5169 · Cited by 1,058
Self-citationRetrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models
Liu, B., Ramsundar, B., Kawthekar, P., Shi, J., Gomes, J., Luu Nguyen, Q., Ho, S., Sloane, J., Wender, P., & Pande, V. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00303 · Cited by 536
Cited by
Structure-Based Drug Design with a Deep Hierarchical Generative Model
Weller, J. A., & Rohs, R. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01193 · Cited by 47
Metadata
- Authors
- Campos, K. R., Coleman, P. J., Alvarez, J. C., Dreher, S. D., Garbaccio, R. M., Terrett, N. K., Tillyer, R. D., Truppo, M. D., & Parmee, E. R.
- Venue
- Science
- Published
- 2019-01-18
- Volume
- 363
- Issue
- 6424
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2909929882
- Cited by
- 668
- References
- 2
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Campos, K. R., Coleman, P. J., Alvarez, J. C., Dreher, S. D., Garbaccio, R. M., Terrett, N. K., Tillyer, R. D., Truppo, M. D., & Parmee, E. R. (2019). The importance of synthetic chemistry in the pharmaceutical industry. Science. https://doi.org/10.1126/science.aat0805
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