The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
mRNA structure determines specificity of a polyQ-driven phase separation
Open accessAbstract
RNA and membraneless organelles: Membraneless compartments can form in cells through liquidliquid phase separation (see the Perspective by Polymenidou). But what prevents these cellular condensates from randomly fusing together? Using the RNA-binding protein (RBP) Whi3, Langdon et al. demonstrated that the secondary structure of different RNA components determines the distinct biophysical and biological properties of the two types of condensates that Whi3 forms. Several RBPs, such as FUS and TDP43, contain prion-like domains and are linked to neurodegenerative diseases. These RBPs are usually soluble in the nucleus but can form pathological aggregates in the cytoplasm. Maharana et al. showed that local RNA concentrations determine distinct phase separation behaviors in different subcellular locations. The higher RNA concentrations in the nucleus act as a buffer to prevent phase separation of RBPs; when mislocalized to the cytoplasm, lower RNA concentrations trigger aggregation. Science , this issue p. 922 , p. 918 ; see also p. 859
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Self-citationRNA phase transitions in repeat expansion disorders
(2017) · doi:10.1038/nature22386 · Cited by 911
RNA Controls PolyQ Protein Phase Transitions
Zhang, H., Elbaum-Garfinkle, S., Langdon, E. M., Taylor, N., Occhipinti, P., Bridges, A. A., Brangwynne, C. P., & Gladfelter, A. S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.017 · Cited by 709
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Molecular interactions underlying liquid‐liquid phase separation of the FUS low‐complexity domain
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Metadata
- Authors
- Langdon, E. M., Qiu, Y., Ghanbari Niaki, A., McLaughlin, G. A., Weidmann, C. A., Gerbich, T. M., Smith, J. A., Crutchley, J. M., Termini, C. M., Weeks, K. M., Myong, S., & Gladfelter, A. S.
- Venue
- Science
- Published
- 2018-05-25
- Volume
- 360
- Issue
- 6391
- Pages
- 922-927
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2776559018
- Cited by
- 508
- References
- 20
- FWCI
- 21.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Langdon, E. M., Qiu, Y., Ghanbari Niaki, A., McLaughlin, G. A., Weidmann, C. A., Gerbich, T. M., Smith, J. A., Crutchley, J. M., Termini, C. M., Weeks, K. M., Myong, S., & Gladfelter, A. S. (2018). mRNA structure determines specificity of a polyQ-driven phase separation. Science. https://doi.org/10.1126/science.aar7432
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