The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Open accessAbstract
The MTOC is “speck”-tacular: Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the maturation of inflammatory cytokines and pyroptosis, a type of programmed cell death. One notable feature for inflammasome activation is the formation of a single supramolecular punctum (or “speck”) in each affected cell. However, the location and mechanism of speck formation is poorly understood. Magupalli et al. report that for NLRP3- and pyrin-mediated inflammasomes, their assembly and downstream functions occur at the microtubule-organizing center (MTOC). This process requires the dynein adaptor HDAC6, which is also a central player in aggresome formation and autophagosomal degradation at the MTOC. This work links several important cellular processes and provides clues for how inflammasomes are efficiently regulated. Science , this issue p. eaas8995
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A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458
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Vora, S. M., Lieberman, J., & Wu, H. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00588-x · Cited by 325
Self-citationCryo-EM structures of the active NLRP3 inflammasome disc
Xiao, L., Magupalli, V. G., & Wu, H. (2023) · Nature · doi:10.1038/s41586-022-05570-8 · Cited by 312
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Metadata
- Authors
- Magupalli, V. G., Negro, R., Tian, Y., Hauenstein, A. V., Di Caprio, G., Skillern, W., Deng, Q., Orning, P., Alam, H. B., Maliga, Z., Sharif, H., Hu, J. J., Evavold, C. L., Kagan, J. C., Schmidt, F. I., Fitzgerald, K. A., Kirchhausen, T., Li, Y., & Wu, H.
- Venue
- Science
- Published
- 2020-09-18
- Volume
- 369
- Issue
- 6510
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3087139986
- Cited by
- 382
- References
- 68
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Magupalli, V. G., Negro, R., Tian, Y., Hauenstein, A. V., Di Caprio, G., Skillern, W., Deng, Q., Orning, P., Alam, H. B., Maliga, Z., Sharif, H., Hu, J. J., Evavold, C. L., Kagan, J. C., Schmidt, F. I., Fitzgerald, K. A., Kirchhausen, T., Li, Y., & Wu, H. (2020). HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. https://doi.org/10.1126/science.aas8995
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