The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Programmable protein circuits in living cells
Open accessAbstract
Building smarter synthetic biological circuits: Synthetic genetic and biological regulatory circuits can enable logic functions to form the basis of biological computing; synthetic biology can also be used to control cell behaviors (see the Perspective by Glass and Alon). Andrews et al. used mathematical models and computer algorithms to combine standardized components and build programmable genetic sequential logic circuits. Such circuits can perform regulatory functions much like the biological checkpoint circuits of living cells. Circuits composed of interacting proteins could be used to bypass gene regulation, interfacing directly with cellular pathways without genome modification. Gao et al. engineered proteases that regulate one another, respond to diverse inputs that include oncogene activation, process signals, and conditionally activate responses such as those leading to cell death. This platform should facilitate development of “smart” therapeutic circuits for future biomedical applications. Science , this issue p. eaap8987 , p. 1252 ; see also p. 1199
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Cited by
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Metadata
- Authors
- Gao, X. J., Chong, L. S., Kim, M. S., & Elowitz, M. B.
- Venue
- Science
- Published
- 2018-09-21
- Volume
- 361
- Issue
- 6408
- Pages
- 1252-1258
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4249558460
- Cited by
- 317
- References
- 68
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- green
- Funders
- Howard Hughes Medical Institute
- NIH Office of the Director (T32 GM07616)
- Gordon and Betty Moore Foundation (GMBF2809)
- Helen Hay Whitney Foundation (F1047)
- Defense Sciences Office, DARPA (HR0011-17-2-0008)
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