The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering
Abstract
Metabolic engineering allows development of microbial strains efficiently producing chemicals and materials, but it requires much time, effort, and cost to make the strains industrially competitive. Systems metabolic engineering, which integrates tools and strategies of systems biology, synthetic biology, and evolutionary engineering with traditional metabolic engineering, has recently been used to facilitate development of high-performance strains. The past decade has witnessed this interdisciplinary strategy continuously being improved toward the development of industrially competitive overproducer strains. In this article, current trends in systems metabolic engineering including tools and strategies are reviewed, focusing on recent developments in selection of host strains, metabolic pathway reconstruction, tolerance enhancement, and metabolic flux optimization. Also, future challenges and prospects are discussed.
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Cites
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Cited by
Bacterial biopolymers: from pathogenesis to advanced materials
Moradali, M. F., & Rehm, B. H. A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0313-3 · Cited by 459
Powerful tools for productivity improvements in microalgal production
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Johnson, Z., Anderson, D., Cheung, M. S., & Bohutskyi, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1569559 · Cited by 12
Metadata
- Authors
- Choi, K. R., Jang, W. D., Yang, D., Cho, J. S., Park, D., & Lee, S. Y.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 37
- Issue
- 8
- Pages
- 817-837
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2912479692
- Cited by
- 566
- References
- 183
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Choi, K. R., Jang, W. D., Yang, D., Cho, J. S., Park, D., & Lee, S. Y. (2019). Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2019.01.003
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