The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase
Abstract
A cap-specific m 6 A writer: N 6 ,2′- O -dimethyladenosine (m 6 Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al. quantified the abundance of this modification in the transcriptome and identified the writer protein, cap-specific adenosine methyltransferase (CAPAM), needed for this modification. CAPAM contains a unique structure that recognizes cap-specific N 6 -methyladenosine (m 6 A) as the substrate. The protein interacts with RNA polymerase II, suggesting that the modification occurs cotranscriptionally. The m 6 Am promotes the translation of capped mRNAs in a eIF4E-independent fashion. Science , this issue p. eaav0080
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Metadata
- Authors
- Akichika, S., Hirano, S., Shichino, Y., Suzuki, T., Nishimasu, H., Ishitani, R., Sugita, A., Hirose, Y., Iwasaki, S., Nureki, O., & Suzuki, T.
- Venue
- Science
- Published
- 2019-01-11
- Volume
- 363
- Issue
- 6423
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2901594129
- Cited by
- 361
- References
- 63
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Akichika, S., Hirano, S., Shichino, Y., Suzuki, T., Nishimasu, H., Ishitani, R., Sugita, A., Hirose, Y., Iwasaki, S., Nureki, O., & Suzuki, T. (2019). Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase. Science. https://doi.org/10.1126/science.aav0080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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