The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
m 6 A RNA methylation: from mechanisms to therapeutic potential
Open accessAbstract
RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N6‐methyladenosine (m6A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification. m6A methylation regulates gene expression by influencing numerous aspects of mRNA metabolism, including pre‐mRNA processing, nuclear export, decay, and translation. The importance of m6A methylation as a mode of post‐transcriptional gene expression regulation is evident in the crucial roles m6A‐mediated gene regulation plays in numerous physiological and pathophysiological processes. Here, we review current knowledge on the mechanisms by which m6A exerts its functions and discuss recent advances that underscore the multifaceted role of m6A in the regulation of gene expression. We highlight advances in our understanding of the regulation of m6A deposition on mRNA and its context‐dependent effects on mRNA decay and translation, the role of m6A methylation of non‐coding chromosomal‐associated RNA species in regulating transcription, and the activities of the RNA demethylase FTO on diverse substrates. We also discuss emerging evidence for the therapeutic potential of targeting m6A regulators in disease.
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Cites
Double-slit photoelectron interference in strong-field ionization of the neon dimer
Kunitski, M., Eicke, N., Huber, P., Köhler, J., Zeller, S., Voigtsberger, J., Schlott, N., Henrichs, K., Sann, H., Trinter, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07882-8 · Cited by 8,162
Double-slit photoelectron interference in strong-field ionization of the neon dimer
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
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Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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“An important facet of m 6 A methylation as a regulatory system is its reversibility. m 6 A on mRNA can be removed by FTO and ALKBH5, m 6 A demethylases, posing an additional dimension of regulation for the m 6 A epitranscriptome (Jia et al , 2011; Zheng et al , 2013).”
Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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“More than 99% of total m 6 A in polyadenylated mRNA is deposited by a heterodimeric complex composed of METTL3-METTL14 in a highly specific manner (Shi et al , 2019; Zaccara et al , 2019). m 6 A influences splicing, degradation, and translation of mRNA (Knuckles & B € uhler, 2018; He & He, 2021).”
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Chen, X., Xu, H., Shu, X., & Song, C.-X. (2025) · Cell Death & Differentiation · doi:10.1038/s41418-023-01213-1 · Cited by 105
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
Quarto, G., Li Greci, A., Bizet, M., Penning, A., Primac, I., Murisier, F., Garcia-Martinez, L., Borges, R. L., Gao, Q., Cingaram, P. K. R., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.009 · Cited by 50
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m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs
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Metadata
- Authors
- He, P. C., & He, C.
- Venue
- The EMBO Journal
- Published
- 2021-01-20
- Volume
- 40
- Issue
- 3
- Pages
- e105977-e105977
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W3121941032
- Cited by
- 786
- References
- 160
- FWCI
- 34.01
- Type
- journal article
- Language
- en
- Open access
- green
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