The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses
Abstract
A nuclear sensor of viral DNA?: A signaling pathway in eukaryotes known as cGAS–STING recognizes the presence of cytosolic DNA, which alerts the immune system to viral infection or cellular damage. However, the majority of DNA viruses direct their genomic DNA into nuclei, suggesting that nuclear-specific sensing is also needed. L. Wang et al. find that during herpes simplex virus–1 infection, heterogeneous nuclear ribonucleoprotein A2B1 forms a complex with viral DNA, homodimerizes, and is demethylated. These events result in translocation of the complex to the cytosol and activation of the immune system through type I interferon signaling. Additionally, the complex promotes N 6 -methyladenosine modification and translocation of cGAS–STING–related mRNAs after DNA virus infection, further amplifying the immune response. Science , this issue p. eaav0758
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,676
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Pérez-Hernández, D., Vázquez, J., Martin-Cofreces, N., Martinez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,971
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,715
Honda, K., & Taniguchi, T. (2006) · Nature Reviews Immunology · doi:10.1038/nri1900 · Cited by 1,676
IFI16 is an innate immune sensor for intracellular DNA
Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Alarcón, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.08.011 · Cited by 1,514
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Atasheva, S., Yao, J., & Shayakhmetov, D. M. (2019) · FEBS Letters · doi:10.1002/1873-3468.13696 · Cited by 87
Deng, Z., Cai, W., Liu, J., Deng, A., Yang, Y., Tu, J., Yuan, C., Xiao, H., & Gao, W. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5006 · Cited by 15
Metadata
- Authors
- Wang, L., Wen, M., & Cao, X.
- Venue
- Science
- Published
- 2019-08-16
- Volume
- 365
- Issue
- 6454
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2962454748
- Cited by
- 348
- References
- 43
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
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